Integrated analysis and systematic characterization of the regulatory network for human germline development
| Title | Integrated analysis and systematic characterization of the regulatory network for human germline development |
|---|---|
| Description | Primordial germ cells are the precursors of germline that are specified at embryonic stage. Recent studies reveal that humans employ different mechanisms for PGC specification compared with model organisms such as mice. Moreover, the specific regulatory machinery remains largely unexplored, mainly due to the inaccessible nature of this complex biological process in humans. Here, we curate and integrate multi-omics data, including 581 RNA-seq, 54 ATAC-seq, 45 ChIP-seq, and 69 single-cell RNA-seq samples from different stages of human PGC development to recapitulate the precisely controlled and stepwise process, presenting an atlas in the human PGC database. |
| Organism | Homo sapiens |
| Data Type | Other Type of Genomic Data |
| Data Accessibility | Open-access |
| BioProject | PRJCA030546 |
| Release Date | 2024-09-27 |
| Submitter | Yashi Gu (yashi.21@intl.zju.edu.cn) |
| Organization | Zhejiang University |
| Submission Date | 2024-09-26 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007508-01 | Bulk RNA-seq count matrix | 581 | Other Type of Genomic Data | 17.29 MB | csv.tar.gz | 0 | |
| OMIX007508-02 | Bulk ChIP-seq bigwig | 45 | Other Type of Genomic Data | 6.02 GB | tar.gz | 0 | |
| OMIX007508-03 | scRNA-seq matrix | 73 | Other Type of Genomic Data | 2.94 GB | tar.gz | 0 | |
| OMIX007508-04 | Bulk ATAC-seq bigwig | 53 | Other Type of Genomic Data | 4.15 GB | tar.gz | 0 |