Intermittent Hypoxia Induces Changes in the Pulmonary Microbiome and Metabolites in a Mouse Model of Obstructive Sleep Apnea Syndrome
| Title | Intermittent Hypoxia Induces Changes in the Pulmonary Microbiome and Metabolites in a Mouse Model of Obstructive Sleep Apnea Syndrome |
|---|---|
| Description | This study subjected C57BL/6J mice to intermittent hypoxia (IH) treatment for 4 weeks. We used LC-MS metabolomics to analyze the metabolites in the bronchoalveolar lavage fluid. The results revealed that after intermittent hypoxia treatment, the pulmonary metabolic levels were significantly disrupted. The altered metabolites mainly included Prostaglandin E2, Stachydrine, Cohumulone, Nootkatone, and Embelin, which are related to various metabolic pathways. The involved metabolic pathways mainly include nicotinic acid and nicotinamide metabolism, regulation of inflammatory mediators by TRP channels, neuroactive ligand-receptor interaction, histidine metabolism, and nucleotide metabolism. |
| Organism | Mus musculus |
| Data Type | Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility | Open-access |
| BioProject | PRJCA030083 |
| Release Date | 2024-11-13 |
| Submitter | xinxing huang (Manipulation66@163.com) |
| Organization | Xuzhou Medical University |
| Submission Date | 2024-11-12 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007874-01 | Alveolar lavage fluid metabolome data | 1 | Metabolome Data by Mass Spectrometry (MS) | 71.1 MB | zip | 0 |