Sputum Proteome Reveals Cilium-Associated Endotypes and Prognostic Immunoglobulin Markers Among Acute Exacerbation of Chronic Obstructive Pulmonary Disease
| Title | Sputum Proteome Reveals Cilium-Associated Endotypes and Prognostic Immunoglobulin Markers Among Acute Exacerbation of Chronic Obstructive Pulmonary Disease |
|---|---|
| Description | Chronic Obstructive Pulmonary Disease (COPD) is characterized by acute exacerbations (AECOPD), yet reliable diagnostic and prognostic markers for AECOPD remain elusive. Consensus clustering identified two novel AECOPD endotypes: cilium-enriched and cilium-depleted. The cilium module was associated with sIgA and immunoglobulin variable regions across all AECOPD patients, while the cilium-enriched endotype showed a strong association with MUC5AC, indicating an enhanced airway mucosal immune response and increased ciliogenesis to improve impaired mucociliary clearance. In contrast, the cilium-depleted endotype, characterized by lower MUC5AC and decreased immunoglobulin levels, appeared to prioritize actin polymerization and wound healing over ciliogenesis to restore airway integrity. These findings suggest potential biomarkers and novel endotypes that could inform targeted therapies for AECOPD. |
| Organism | Homo sapiens |
| Data Type | Proteomic Data by Mass Spectrometry (MS) |
| Data Accessibility | Controlled-access |
| BioProject | PRJCA032026 |
| Release Date | 2024-11-21 |
| Submitter | Lingwei Wang (wang.lingwei@szhospital.com) |
| Organization | Shenzhen People's Hospital |
| Submission Date | 2024-11-19 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX007953-01 | Batch2 Proteome Result | 48 | Proteomic Data by Mass Spectrometry (MS) | 131.89 GB | zip | 0 | Controlled |
| OMIX007953-02 | Batch1 Proteome Result | 27 | Proteomic Data by Mass Spectrometry (MS) | 84.84 GB | zip | 0 | Controlled |