| Title |
Glutaminolysis is a cutaneous type 3 inflammatory microenvironment-specific metabolic adaptation in keratinocyte and promotes skin inflammation (Metabolome) |
| Description |
Disturbed skin homeostasis by inflammatory cytokines couples with alterations of keratinocytes-intrinsic metabolic fluxes. Precisely which metabolic scenarios are involved and the underlying mechanisms on keratinocytes activation are poorly defined. We report here that GLS1-mediated glutaminolysis is a skin-specific type 3 inflammatory cytokines-sensing metabolic pathway and required for keratinocytes' hyperproliferation. Metabolic profiling, and in vitro rescue experiments reveal that GLS1-mediated glutaminolysis is associated with the arginine, methionine and proline biosynthesis to maintain cytosolic amino-acid-regulated mTORC1 activation, and modulates redox homeostasis in hyperproliferative keratinocytes. |
| Organism |
Mus musculus |
| Data Type |
Metabolome Data by Mass Spectrometry (MS) |
| Data Accessibility |
Open-access |
| BioProject |
PRJCA050524 |
| Release Date |
2025-12-31 |
| Submitter |
Yongfei Hu (yongfei_hu_joe@163.com) |
| Organization |
Southern Medical University |
| Submission Date |
2025-11-14 |