Gadd45a is a heterochromatin relaxer that enhances iPS cell generation
| Title | Gadd45a is a heterochromatin relaxer that enhances iPS cell generation |
|---|---|
| Description | We identify growth arrest and DNA damage-inducible protein a (Gadd45a) as a chromatin relaxer in mouse embryonic fibroblasts, which also enhances somatic cell reprogramming efficiency. We show that residue glycine 39 (G39) in Gadd45a is essential for interacting with core histones, opening chromatin and enhancing reprogramming. We further demonstrate that Gadd45a destabilizes histone-DNA interactions and facilitates the binding of Yamanaka factors to their targets for activation |
| Organism | Mus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA004680 |
| Release Date | 2021-05-20 |
| Submitter | Yuan Wang (ywang@bio.ecnu.edu.cn) |
| Organization | East China Normal University |
| Submission Date | 2021-05-20 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX316-20-01 | GSE56944_RAW | 4 | Transcriptomic | 37.0 MB | rar |