Transcriptome of Peripheral Blood in MECP2 Mutant Monkeys and RTT Patients
| Title | Transcriptome of Peripheral Blood in MECP2 Mutant Monkeys and RTT Patients |
|---|---|
| Description | Since peripheral blood from RTT patients is more easily accessible than other tissues, analyses of blood samples for biomarkers may facilitate diagnosis and/or serve as outcome measures for potential clinical interventions. We thus profifiled blood transcriptomes of monkeys to uncover potential endophenotype or biomarkers. Through weighted gene coexpression network analyses (WGCNA) , we isolated three inter connected gene modules/clusters, which were expressed at different levels between mutant and WT monkeys ). Module-trait correlation matrix demonstrated that these gene clusters were either downregulated (brown and blue modules) or upregulated (turquoise module) in MECP2 mutant animals with statistical signifificance |
| Organism | Macaca fascicularis |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA006145 |
| Release Date | 2021-08-23 |
| Submitter | niu yu (niuyy@lpbr.cn) |
| Organization | Kunming University of Science Technology |
| Submission Date | 2021-08-23 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX537-20-01 | Figure1 Gene-Network Modules Associated with MECP2 Mutations in Monkeys and Human via WGCNA | 1 | Transcriptomic | 224.7 KB | 2 | ||
| OMIX537-20-02 | Figure2 RNA-Seq Analysis of Human Peripheral Blood Samples of RTT Patients and Healthy Controls | 1 | Transcriptomic | 136.2 KB | 2 |