Nontargeted, pseudotargeted and lipid metabolome of plasma and ovaries from control group, POI group and hUCMSC group of mice
| Title | Nontargeted, pseudotargeted and lipid metabolome of plasma and ovaries from control group, POI group and hUCMSC group of mice |
|---|---|
| Description | POI mice model was generated by cyclophosphamide and busulfan in 6-week-old female mice, followed with the treatment of tail-vein injection of the human umbilical cord mesenchymal stem cells (hUCMSCs). Maternal physiological changes and offspring behavior were detected. To reveal the pathogenesis and therapeutic mechanisms of POI, we first compared the metabolite profiles of healthy and POI ovarian tissues using nontargeted metabolomics analyses. After stem cell therapy, we then collected the ovaries from control, POI, and hUCMSC-treated POI groups for lipid metabolomics and pseudotargeted metabolomics analysis. |
| Organism | Mus musculus |
| Data Type | - |
| Data Accessibility | Open-access |
| BioProject | PRJCA008225 |
| Release Date | 2022-12-31 |
| Submitter | Long Yan (yanlong@ioz.ac.cn) |
| Organization | Institute of Zoology, Chinese Academy of Sciences |
| Submission Date | 2022-03-03 |
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| File ID | File Title | Number/Samples | File Type | File Size | File Suffix | Download Times | Download |
|---|---|---|---|---|---|---|---|
| OMIX981-30-01 | Nontargeted metabolome of ovaries from control group and POI group of mice | 70 | Metabonomics | 14.81 GB | tar | 0 | |
| OMIX981-30-02 | Pseudotargeted metabolome of ovaries from control group, POI group and hUCMSC-treated group of mice | 130 | Metabonomics | 2.24 GB | tar | 0 | |
| OMIX981-40-03 | Lipid metabolome of ovaries from control group, POI group and hUCMSC-treated group of mice | 88 | Lipidomics | 10.58 GB | tar | 0 | |
| OMIX981-30-04 | Nontargeted metabolome of plasma from control group and POI group of mice | 67 | Metabonomics | 13.98 GB | tar | 0 |