Inhibition of cholesterol absorption by HMG-CoA reductase inhibitor.

T A Miettinen
Author Information
  1. T A Miettinen: Second Department of Medicine, University of Helsinki, Finland.

Abstract

In subjects with familial hypercholesterolemia cholesterol absorption efficiency was insignificantly reduced during a short-term more consistently during long-term pravastatin treatment. A cholesterol feeding had no effect on LDL cholesterol level but reduced absorption efficiency during a long-term lovastatin treatment.

References

Metabolism. 1989 Feb;38(2):136-40 [PMID: 2913464]
Proc Natl Acad Sci U S A. 1984 Apr;81(8):2538-42 [PMID: 6371816]
Metabolism. 1989 Jun;38(6):542-9 [PMID: 2725293]
Biochim Biophys Acta. 1989 Jul 17;1004(1):117-23 [PMID: 2742865]
Scand J Clin Lab Invest. 1980;40(7):671-4 [PMID: 7466296]
Scand J Clin Lab Invest. 1975 Nov;35(7):677-82 [PMID: 174187]
J Lipid Res. 1988 Jan;29(1):43-51 [PMID: 3356951]
Am J Clin Nutr. 1986 Jan;43(1):92-7 [PMID: 3942097]
Am J Clin Nutr. 1989 Apr;49(4):629-35 [PMID: 2929484]
N Engl J Med. 1988 Jul 7;319(1):24-33 [PMID: 3288867]
Am J Epidemiol. 1990 Jan;131(1):20-31 [PMID: 2293749]
Biochim Biophys Acta. 1988 Nov 4;963(1):35-41 [PMID: 3179328]
J Clin Invest. 1987 Dec;80(6):1692-7 [PMID: 3680522]
J Lipid Res. 1982 Jul;23(5):774-81 [PMID: 7119575]
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1003-8 [PMID: 3619910]
Biochem Biophys Res Commun. 1987 Nov 13;148(3):920-5 [PMID: 3689403]
J Lipid Res. 1988 Sep;29(9):1149-55 [PMID: 3183524]

MeSH Term

Cholesterol, Dietary
Heptanoic Acids
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Hyperlipoproteinemia Type II
Intestinal Absorption
Lovastatin
Naphthalenes
Pravastatin

Chemicals

Cholesterol, Dietary
Heptanoic Acids
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Naphthalenes
Lovastatin
Pravastatin

Word Cloud

Similar Articles

Cited By