In an attempt to elucidate the relationship between endogenous methionine-enkephalin (ME) and vasoactive intestinal polypeptide (VIP) with generalized seizures, we determined regional brain levels of ME-like and VIP-like immunoreactivity (ME-LI and VIP-LI) in El mice during and after seizures induced by repeated tossing stimulation. The levels of ME-LI in the striatum and hippocampus of seizure-naive El mice (El-) were lower than those of the control ddY mice, the mother strain of El mice. Conversely, the level of VIP-LI in the medulla oblongata and pons of El- was higher than that of ddY mice. The level of ME-LI in the striatum of seizure-experienced El mice (El+) killed 96 hours after three consecutive seizures was high, while levels of VIP-LI in the striatum and hypothalamus were low, in comparison to those of El- mice. A detailed time-course study revealed that seizures in El mice caused (1) significant decreases in levels of ME-LI in the striatum and hippocampus during seizures, (2) a significant decrease of VIP-LI content in the striatum 3 hours after seizures, and (3) a significant increase in hypothalamic VIP-LI 9 hours after seizures. These observations suggest that ME and VIP may play some role in El mouse seizures.
Brain Res. 1980 Oct 27;200(1):93-103
[PMID:
6251946]
J Neurosci. 1986 Oct;6(10):3094-102
[PMID:
2876067]
Biochem Pharmacol. 1978;27(18):2209-13
[PMID:
83146]
Life Sci. 1979 Feb 5;24(6):541-8
[PMID:
431335]
J Neurochem. 1976 Jan;26(1):5-10
[PMID:
176320]
Science. 1978 Apr 21;200(4339):335-7
[PMID:
204998]
Brain Res. 1983 May 5;266(2):359-63
[PMID:
6871672]
Neuropeptides. 1983 Jul;3(5):399-404
[PMID:
6137784]
Prog Brain Res. 1966;21:112-29
[PMID:
5939640]
J Pharmacol Exp Ther. 1978 Apr;205(1):141-7
[PMID:
24732]
Brain Res. 1978 May 26;147(2):327-37
[PMID:
206315]
Brain Res. 1981 Apr 6;210(1-2):243-52
[PMID:
7225810]
Science. 1977 Jul 1;197(4298):83-6
[PMID:
867056]
Electroencephalogr Clin Neurophysiol. 1982 Jul;54(1):91-5
[PMID:
6177523]
Experientia. 1976 Mar 15;32(3):336-8
[PMID:
1253902]
Electroencephalogr Clin Neurophysiol. 1977 Sep;43(3):299-311
[PMID:
70331]
Neurosci Lett. 1981 Oct 23;26(2):125-30
[PMID:
7301200]
J Neurochem. 1971 Jun;18(6):1087-96
[PMID:
4398115]
Brain Res. 1985 Jul 15;338(2):327-36
[PMID:
3161584]
Brain Res. 1986 Feb 12;365(1):185-91
[PMID:
2868784]
J Neurosci. 1986 Mar;6(3):644-9
[PMID:
2870139]
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5221-5
[PMID:
283426]
Regul Pept. 1983 Aug;6(4):385-92
[PMID:
6138821]
Folia Psychiatr Neurol Jpn. 1981;35(3):261-6
[PMID:
6173293]
Brain Res. 1986 Aug 13;380(1):76-82
[PMID:
3019467]
J Pharm Pharmacol. 1980 Aug;32(8):561-6
[PMID:
6106694]
Brain Res. 1987 Jan 20;401(2):353-8
[PMID:
2880644]
Proc Natl Acad Sci U S A. 1985 Jan;82(2):589-93
[PMID:
2578669]
Neurosci Lett. 1986 Aug 29;69(2):208-11
[PMID:
3763049]
J Neurochem. 1966 Aug;13(8):655-69
[PMID:
5950056]
Brain Res. 1979 Jan 5;160(1):192-5
[PMID:
758222]
Neurosci Lett. 1986 Oct 30;71(1):31-6
[PMID:
2878396]
Eur J Pharmacol. 1983 May 20;90(1):85-9
[PMID:
6873178]
Life Sci. 1981 May 18;28(20):2287-93
[PMID:
7195971]
Neuroscience. 1986 Apr;17(4):1117-26
[PMID:
2423920]
Brain Res. 1982 Dec 16;253(1-2):337-40
[PMID:
7150973]
