Chromosomal localization of four human VH1-like protein-tyrosine phosphatases.

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K J Martell, S Kwak, D J Hakes, J E Dixon, J M Trent

Author Information

K J Martell: Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109.

PMID: 7806236 DOI: 10.1006/geno.1994.1411

Four human protein-tyrosine phosphatase (PTPase) genes of the VH1-like subclass were cloned by low-stringency screening of a genomic library. These genes were localized to their respective chromosomes by G-banding and fluorescence in situ hybridization. The genes were localized to unique regions of different chromosomes: CL100, a stress-induced PTPase, to 5q35; PAC-1, a mitogen-induced nuclear PTPase, to 2q11;hVH-3 to 10q25; and hVH-4 to 10q11.

AM 18024/NIADDK NIH HHS
CA-29476/NCI NIH HHS

Amino Acid Sequence

Chromosome Mapping

Chromosomes, Human, Pair 10

Chromosomes, Human, Pair 2

Chromosomes, Human, Pair 5

Dual-Specificity Phosphatases

Humans

In Situ Hybridization, Fluorescence

Protein Tyrosine Phosphatases

Sequence Alignment

Sequence Homology, Amino Acid

dual specificity phosphatase 12

Dual-Specificity Phosphatases

Protein Tyrosine Phosphatases

Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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