Intrabrain transplantation of chromaffin cell aggregates of the Zuckerkandl's organ, an extra-adrenal paraganglion that has never been tested for antiparkinsonian treatment, induced gradual improvement of functional deficits in parkinsonian rats. These beneficial effects were related to long survival of grafted cells, striatal reinnervation, and enhancement of dopamine levels in grafted striatum. Grafted cells were not dopaminergics, but they expressed glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta(1). These factors were detected in the host striatal tissue, indicating that chromaffin cells secreted them after grafting. Because glial cell line-derived neurotrophic factor possesses neurorestorative properties over dopaminergic neurons, and transforming growth factor-beta(1) is a cofactor that potentiates the neurotrophic actions of GDNF, functional regeneration was likely caused by the chronic trophic action of neurotrophic factors delivered by long-surviving grafted cells. This work should stimulate research on the clinical applicability of transplants of the Zuckerkandl's organ in Parkinson's disease.
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Adrenal Medulla
Animals
Cell Transplantation
Chromaffin Cells
Corpus Striatum
Disease Models, Animal
Dopamine
Gene Expression
Glial Cell Line-Derived Neurotrophic Factor
Graft Survival
Motor Activity
Nerve Growth Factors
Nerve Tissue Proteins
Oxidopamine
Para-Aortic Bodies
Parkinson Disease, Secondary
Rats
Rats, Wistar
Recovery of Function
Regeneration
Substantia Nigra
Synaptic Transmission
Transforming Growth Factor beta
Transforming Growth Factor beta1
Treatment Outcome
Gdnf protein, rat
Glial Cell Line-Derived Neurotrophic Factor
Nerve Growth Factors
Nerve Tissue Proteins
Tgfb1 protein, rat
Transforming Growth Factor beta
Transforming Growth Factor beta1
Oxidopamine
Dopamine
