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Veterinary dermatology
Feb, 2003;14 (1): 11-22.

Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel, blinded, randomized controlled trial.

Jean Steffan, Deborah Alexander, Fabienne Brovedani, Roland D Fisch
Author Information
  1. Jean Steffan: Novartis Animal Health Inc., CH 4002, Basel, Switzerland.
  2. Deborah Alexander: Novartis Animal Health Inc., CH 4002, Basel, Switzerland.
  3. Fabienne Brovedani: Novartis Animal Health Inc., CH 4002, Basel, Switzerland.
  4. Roland D Fisch: Novartis Animal Health Inc., CH 4002, Basel, Switzerland.
PMID: 12603681 DOI: 10.1046/j.1365-3164.2003.00318.x

Abstract

The objective of this multicentre, parallel, blinded, randomized controlled study was to evaluate the efficacy and the safety of cyclosporine (CsA group, 117 dogs) in comparison with methylprednisolone (MP group, 59 dogs) in the treatment of atopic dermatitis for 4 months. Mean induction dose of both drugs (5 mg/kg CsA, 0.75 mg/kg MP) was tapered over time according to the clinical response. At the end of the study, the mean estimated percentage reduction from baseline (confidence interval) of lesion scores was 52% (44-59) and 45% (35-56), and the reduction in pruritus score was 36% (27-43) and 33% (23-43) in dogs in the CsA and MP groups, respectively. These percentages were not significantly different between groups. A significantly better overall assessment of efficacy was obtained in the CsA-treated dogs (76 vs. 63% responses excellent or good in the CsA compared with MP group). CsA-treated dogs presented a higher frequency of gastrointestinal disorders, mainly vomiting, but MP dogs tended to be more susceptible to infections. There was no remarkable change over baseline of the haematological and biochemical parameters in the two groups.

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MeSH Term

Administration, Oral
Animals
Anti-Inflammatory Agents
Cyclosporine
Dermatitis, Atopic
Dermatologic Agents
Dog Diseases
Dogs
Double-Blind Method
Drug Administration Schedule
Female
Male
Methylprednisolone
Treatment Outcome

Chemicals

Anti-Inflammatory Agents
Dermatologic Agents
Cyclosporine
Methylprednisolone
Clinical Trial Comparative Study Journal Article Randomized Controlled Trial Research Support, Non-U.S. Gov't

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