Seiko Otokozawa, Masumi Ai, Thomas Van Himbergen, Bela F Asztalos, Akira Tanaka, Evan A Stein, Peter H Jones, Ernst J Schaefer
Atorvastatin and rosuvastatin at maximal doses are both highly effective in lowering low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) levels. Rosuvastatin has been shown to be more effective than atorvastatin in lowering LDL-C, small dense LDL-C and in raising high-density lipoprotein (HDL) and its subclasses. Intestinal lipoproteins containing apolipoprotein (apo) B-48 are also thought to be atherogenic particles. Our purpose in this study was to compare the effects of daily oral doses of atorvastatin 80 mg/day and rosuvastatin 40 mg/day over a 6-week period on serum apo B-48 (a marker of intestinal lipoproteins) and remnant lipoprotein cholesterol (RemL-C) levels (a marker of partially metabolized lipoproteins of both intestinal and liver origin), using novel direct assays in 270 hyperlipidemic men and women. Both atorvastatin and rosuvastatin caused significant (p<0.0001) and similar median decreases in TG (-33.0%, -27.6%), RemL-C (-58.7%, -61.5%), and apoB-48 (-37.5%, -32.1%) as compared to baseline. Our findings utilizing a specific immunoassay and a fairly large number of subjects extend prior studies indicating that statins significantly lower apolipoprotein B containing lipoproteins of both intestinal and liver origin.
Clin Chem. 1998 Mar;44(3):522-31
[PMID:
9510857]
Arterioscler Thromb Vasc Biol. 2003 May 1;23(5):847-52
[PMID:
12637338]
Am J Cardiol. 2008 Feb 1;101(3):315-8
[PMID:
18237592]
Arterioscler Thromb Vasc Biol. 2004 Nov;24(11):2181-7
[PMID:
15388521]
J Lipid Res. 1988 Jul;29(7):925-36
[PMID:
3411251]
J Clin Endocrinol Metab. 2004 Oct;89(10):5021-9
[PMID:
15472200]
Metabolism. 2000 Aug;49(8):1049-54
[PMID:
10954025]
Metabolism. 2008 Feb;57(2):246-54
[PMID:
18191056]
Am J Cardiol. 2003 Jul 15;92(2):152-60
[PMID:
12860216]
J Lipid Res. 2007 Aug;48(8):1746-53
[PMID:
17526934]
Am J Cardiol. 2001 Nov 15;88(10):1129-33
[PMID:
11703957]
Clin Chem. 1995 May;41(5):717-23
[PMID:
7729051]
Atherosclerosis. 2001 Jan;154(1):229-36
[PMID:
11137104]
Clin Chem. 2007 Dec;53(12):2128-35
[PMID:
17901111]
Metabolism. 2003 Oct;52(10):1279-86
[PMID:
14564679]
Atherosclerosis. 2005 Aug;181(2):345-51
[PMID:
16039289]
Eur J Clin Invest. 1994 Oct;24(10):669-78
[PMID:
7851467]
Am J Cardiol. 2002 Oct 1;90(7):689-96
[PMID:
12356379]
Am J Cardiol. 2007 Mar 1;99(5):681-5
[PMID:
17317371]
Metabolism. 1996 Oct;45(10):1267-72
[PMID:
8843183]
Diabetes Care. 2002 Jun;25(6):989-94
[PMID:
12032104]
Clin Ther. 2004 Sep;26(9):1388-99
[PMID:
15531001]
J Atheroscler Thromb. 2007 Apr;14(2):56-64
[PMID:
17485889]
Arterioscler Thromb Vasc Biol. 2005 Oct;25(10):2185-91
[PMID:
16123324]
J Lipid Res. 2002 Mar;43(3):365-74
[PMID:
11893772]
Am J Cardiol. 2004 Jan 1;93(1):31-9
[PMID:
14697462]
Clin Chim Acta. 2005 Jan;351(1-2):115-20
[PMID:
15563879]
