Unique gene-silencing and structural properties of 2'-fluoro-modified siRNAs.

Muthiah Manoharan, Akin Akinc, Rajendra K Pandey, June Qin, Philipp Hadwiger, Matthias John, Kathy Mills, Klaus Charisse, Martin A Maier, Lubomir Nechev, Emily M Greene, Pradeep S Pallan, Eriks Rozners, Kallanthottathil G Rajeev, Martin Egli
Author Information
  1. Muthiah Manoharan: Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA. mmanoharan@alnylam.com

Abstract

No abstract text available.

References

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Grants

  1. R01 GM055237/NIGMS NIH HHS
  2. R01 GM071461/NIGMS NIH HHS

MeSH Term

Binding Sites
Crystallography, X-Ray
Fluorine
Gene Silencing
Nucleic Acid Conformation
Protein Structure, Tertiary
RNA, Small Interfering
RNA-Induced Silencing Complex
Thermodynamics

Chemicals

RNA, Small Interfering
RNA-Induced Silencing Complex
Fluorine