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Current opinion in neurobiology
Jun, 2012;22 (3): 397-404.

Synapse adhesion: a dynamic equilibrium conferring stability and flexibility.

Deanna L Benson, George W Huntley
Author Information
  1. Deanna L Benson: Department of Neuroscience and the Friedman Brain Institute, Mount Sinai School of Medicine, New York, NY 10029, United States. Deanna.Benson@mssm.edu
PMID: 22019151 DOI: 10.1016/j.conb.2011.09.011

Abstract

Cell adhesion molecules (CAMs) linked to cytoskeleton generate stable cell-cell junctions. Cadherins provide a canonical example, but paradoxically, they participate in a multitude of transient and regulatable interactions. Their extracellular binding generates weak adhesion that is modified by clustering; interactions with F-actin are regulated, can be transient, and can alter F-actin dynamics. Additionally, cadherin recycling from the cell surface can modify the size and location of junctions and strength of adhesion. In epithelial cells, this ongoing dynamic behavior is important for maintaining stable junctions. Recent work supports that cadherins act similarly at synapses where their actions are likely to be shared by integrins and other actin-linked CAMs. Together the collaborative activities of such CAMs provide a stable, but flexible structure that can promote and support changes in synapse shape and size while maintaining stable junctions to permit information flow.

References

Neuron. 2008 May 22;58(4):472-97 [PMID: 18498731]
J Neurosci. 1989 Aug;9(8):2982-97 [PMID: 2769375]
J Neurosci. 2004 Apr 28;24(17):4233-41 [PMID: 15115819]
J Cell Biol. 1995 Jul;130(1):67-77 [PMID: 7790378]
Proc Natl Acad Sci U S A. 2004 Nov 23;101(47):16472-7 [PMID: 15546992]
Curr Opin Neurobiol. 2011 Feb;21(1):132-43 [PMID: 20832286]
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):11116-21 [PMID: 20534458]
Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13438-43 [PMID: 10557339]
Neuron. 2007 Jun 7;54(5):771-85 [PMID: 17553425]
Cell. 2004 Oct 15;119(2):257-72 [PMID: 15479642]
Nat Rev Neurosci. 2007 Mar;8(3):206-20 [PMID: 17299456]
J Cell Sci. 2003 Jan 1;116(Pt 1):17-27 [PMID: 12456712]
EMBO J. 2000 Nov 15;19(22):6020-9 [PMID: 11080149]
Curr Biol. 2008 Nov 11;18(21):1631-8 [PMID: 18976918]
J Cell Biol. 2011 Mar 21;192(6):907-17 [PMID: 21422226]
Cell. 2006 Mar 24;124(6):1255-68 [PMID: 16564015]
Proc Natl Acad Sci U S A. 1990 Nov;87(22):8970-4 [PMID: 2247472]
J Cell Sci. 2007 May 15;120(Pt 10):1818-28 [PMID: 17502486]
Prog Neurobiol. 2008 Mar;84(3):263-83 [PMID: 18206289]
Am J Pathol. 1998 Aug;153(2):333-9 [PMID: 9708792]
Proc Natl Acad Sci U S A. 1990 Jun;87(11):4246-50 [PMID: 2349235]
Nat Cell Biol. 2000 Sep;2(9):637-44 [PMID: 10980705]
Dev Cell. 2002 Sep;3(3):367-81 [PMID: 12361600]
Brain Res. 1991 Dec 6;566(1-2):77-88 [PMID: 1814558]
J Cell Biol. 1978 Oct;79(1):173-83 [PMID: 568145]
Neuron. 2011 Aug 25;71(4):632-9 [PMID: 21867880]
Nature. 1995 Mar 23;374(6520):327-37 [PMID: 7885471]
Curr Opin Cell Biol. 2008 Oct;20(5):557-66 [PMID: 18619539]
Neuron. 2009 Feb 12;61(3):340-50 [PMID: 19217372]
J Cell Biol. 2003 Nov 10;163(3):525-34 [PMID: 14610055]
Mol Cell Neurosci. 2004 Dec;27(4):509-21 [PMID: 15555928]
Neuron. 2007 May 3;54(3):461-77 [PMID: 17481398]
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19520-5 [PMID: 19047646]
Hippocampus. 2012 May;22(5):954-68 [PMID: 20882551]
Proc R Soc Lond B Biol Sci. 1978 Dec 4;203(1151):135-51 [PMID: 33388]
Mol Cell Neurosci. 2005 Sep;30(1):118-30 [PMID: 16046145]
Cell. 1988 Sep 23;54(7):993-1001 [PMID: 3416359]
J Cell Biol. 1988 Oct;107(4):1575-87 [PMID: 3049625]
Cell. 2002 Apr 19;109(2):205-16 [PMID: 12007407]
J Cell Biol. 1979 Nov;83(2 Pt 1):308-19 [PMID: 227912]
Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12113-8 [PMID: 21724987]
Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9182-7 [PMID: 9256456]
J Neurosci. 2011 Jul 20;31(29):10481-93 [PMID: 21775594]
Neuron. 2006 Jul 6;51(1):43-56 [PMID: 16815331]
Neuron. 2002 Oct 24;36(3):435-49 [PMID: 12408846]
J Comp Neurol. 1999 May 17;407(4):453-71 [PMID: 10235639]
Dev Cell. 2002 Aug;3(2):259-70 [PMID: 12194856]
Nature. 2004 Jun 17;429(6993):761-6 [PMID: 15190253]
J Neurosci. 2006 Apr 26;26(17):4586-95 [PMID: 16641238]
Neuroscience. 1998 Nov;87(1):303-15 [PMID: 9722159]
Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5579-84 [PMID: 16567651]
Nature. 1986 Apr 3-9;320(6061):447-9 [PMID: 3515198]
EMBO J. 2002 Jun 3;21(11):2537-46 [PMID: 12032067]
Nat Cell Biol. 2007 Jan;9(1):92-8 [PMID: 17159998]
Cereb Cortex. 2011 Oct;21(10):2217-32 [PMID: 21339376]
J Cell Biol. 2001 Jul 9;154(1):231-43 [PMID: 11449003]
J Neurosci. 1996 Sep 1;16(17):5443-56 [PMID: 8757257]
J Cell Biol. 2000 Aug 7;150(3):567-80 [PMID: 10931868]
Nature. 2009 Dec 17;462(7275):915-9 [PMID: 19946267]
Mol Biol Cell. 2006 Feb;17(2):862-75 [PMID: 16319177]
Nat Protoc. 2009;4(8):1128-44 [PMID: 19617885]
Science. 2002 May 17;296(5571):1308-13 [PMID: 11964443]
Nat Neurosci. 2004 Apr;7(4):357-63 [PMID: 15034585]
Curr Biol. 1999 Dec 2;9(23):1411-4 [PMID: 10607569]
Mol Cell Neurosci. 2001 Aug;18(2):149-67 [PMID: 11520177]
Neuron. 2006 Dec 7;52(5):817-30 [PMID: 17145503]
J Neurosci. 2001 Jul 15;21(14):5169-81 [PMID: 11438592]
Dev Cell. 2005 Sep;9(3):365-76 [PMID: 16224820]
Cell Mol Life Sci. 1998 Jun;54(6):541-8 [PMID: 9676573]
Neuroscience. 2002;115(1):213-27 [PMID: 12401335]
J Neurosci. 2003 Aug 6;23(18):7107-16 [PMID: 12904471]
J Neurosci. 2010 Jul 28;30(30):9984-9 [PMID: 20668183]
Neuron. 2004 Dec 2;44(5):749-57 [PMID: 15572107]
J Neurosci. 2005 Feb 23;25(8):2062-9 [PMID: 15728846]
Nature. 1996 Mar 28;380(6572):360-4 [PMID: 8598933]
Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3528-33 [PMID: 20133579]
Cold Spring Harb Perspect Biol. 2010 Feb;2(2):a000125 [PMID: 20182611]
Neuron. 1998 May;20(5):847-54 [PMID: 9620690]
J Neurosci. 1995 Jun;15(6):4556-71 [PMID: 7790923]
Science. 2008 Feb 15;319(5865):946-8 [PMID: 18276888]
J Cell Biol. 1999 Jul 12;146(1):219-32 [PMID: 10402472]
J Cell Biol. 1990 Feb;110(2):349-57 [PMID: 2153683]
Curr Biol. 1997 May 1;7(5):308-15 [PMID: 9133345]
EMBO J. 1988 Dec 1;7(12):3679-84 [PMID: 3061804]
Nat Cell Biol. 2004 Jan;6(1):21-30 [PMID: 14647292]
J Neurosci. 2006 Oct 25;26(43):11208-19 [PMID: 17065460]
Nat Neurosci. 2001 Jul;4(7):685-6 [PMID: 11426220]
J Cell Biol. 2003 Jul 7;162(1):99-111 [PMID: 12835311]
J Cell Biol. 1997 Oct 20;139(2):517-28 [PMID: 9334353]
Curr Biol. 2008 Nov 11;18(21):1639-48 [PMID: 18976911]
Cell. 2005 Dec 2;123(5):889-901 [PMID: 16325582]
Nature. 2008 Jun 5;453(7196):751-6 [PMID: 18480755]
J Neurosci. 2006 Jan 4;26(1):223-32 [PMID: 16399691]
Nat Cell Biol. 2002 Apr;4(4):E83-90 [PMID: 11944041]
Neuron. 2002 Jul 3;35(1):77-89 [PMID: 12123610]
Trends Cell Biol. 2010 Dec;20(12):734-42 [PMID: 20817460]
J Cell Biol. 1996 Nov;135(3):767-79 [PMID: 8909549]
Cell. 1983 Dec;35(3 Pt 2):631-8 [PMID: 6652680]
Nature. 2009 Dec 17;462(7275):920-4 [PMID: 19946265]
Nat Protoc. 2007;2(3):670-6 [PMID: 17406629]
Mol Biol Cell. 2005 Nov;16(11):5141-51 [PMID: 16120645]
Biochim Biophys Acta. 2009 Apr;1788(4):779-89 [PMID: 19161977]
J Biol Chem. 2006 Mar 17;281(11):7623-34 [PMID: 16377623]
J Biol Chem. 1999 Dec 17;274(51):36734-40 [PMID: 10593980]
Nature. 2006 Aug 3;442(7102):580-4 [PMID: 16862128]
Neurosci Res. 2011 May;70(1):24-9 [PMID: 21352859]
Neuron. 1996 Sep;17(3):423-34 [PMID: 8816706]
Neuron. 2011 Aug 25;71(4):640-55 [PMID: 21867881]
Cell Regul. 1991 Jun;2(6):427-38 [PMID: 1883873]
Dev Dyn. 1993 May;197(1):26-39 [PMID: 8400409]
J Neurosci. 2001 Aug 15;21(16):6245-51 [PMID: 11487647]
Nature. 2009 Jan 15;457(7227):313-7 [PMID: 19005470]

Grants

  1. R01 MH095229/NIMH NIH HHS
  2. R01 NS037731/NINDS NIH HHS
  3. R21 MH099778/NIMH NIH HHS
  4. R01 MH075783/NIMH NIH HHS
  5. NS037731/NINDS NIH HHS
  6. MH075783/NIMH NIH HHS

MeSH Term

Animals
Cell Adhesion
Cell Adhesion Molecules
Cytoskeleton
Intercellular Junctions
Models, Biological
Nonlinear Dynamics
Synapses

Chemicals

Cell Adhesion Molecules
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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