Bone biology and physiology: Part I. The fundamentals.

Donald W Buck, Gregory A Dumanian
Author Information
  1. Donald W Buck: Chicago, Ill. From the Division of Plastic and Reconstructive Surgery, Feinberg School of Medicine, Northwestern University.

Abstract

The principles of bone biology and physiology permeate all subspecialty practices in plastic and reconstructive surgery from hand surgery to aesthetic surgery. Despite its importance in our practices, the biology of bone healing and bone physiology rarely surfaces within textbooks, literature reviews, or residency curricula. In this article, the authors present the first of a two-part series reviewing the important concepts of bone biology and bone physiology relevant to plastic surgery in an effort to ameliorate this educational gap.

References

Clarke B. Normal bone anatomy and physiology. Clin J Am Soc Nephrol. 2008;3:S131–S139.
Taichman RS. Blood and bone: Two tissues whose fates are intertwined to create the hematopoietic stem cell niche. Blood 2005;105:2631–2639.
Buckwalter JA, Glimcher MJ, Cooper RR, Recker R. Bone biology. J Bone Joint Surg Am. 1995;77:1256–1275.
Matos MA, Araujo FP, Paixao FB. Histomorphic evaluation of bone healing in rabbit fibular osteotomy model without fixation. J Orthopaed Surg Res. 2008;3:4–8.
Jepsen KJ. Systems analysis of bone. Wiley Interdiscip Syst Biol Med. 2009;1:73–88.
Cutting CB, McCarthy JG, Berenstein A. Blood supply of the upper craniofacial skeleton: The search for composite calvarial bone flaps. Plast Reconstr Surg. 1984;74:603–610.
Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337–342.
Blair HC, Athanasou NA. Recent advances in osteoclast biology and pathological bone resorption. Histol Histopathol. 2004;19:189–199.
Heath V. Bone: Vitamin D deficiency implicated in bone mineralization defects. Nat Rev Endocrinol. 2009;5:583.
Dickson IR, Millar EA, Veis A. Evidence for abnormality of bone–matrix proteins in osteogenesis imperfecta. Lancet 1975;306:586–587.
Reddi AH, Marshall R. Urist: A renaissance scientist and orthopaedic surgeon. J Bone Joint Surg Am. 2003;85:3–7.
Sommerfeldt DW, Rubin CT. Biology of bone and hot it orchestrates the form and function of the skeleton. Eur Spine J. 2001;10:S86–S95.
Shapiro F. Bone development and its relation to fracture repair: The role of mesenchymal osteoblasts and surface osteoblasts. Eur Cells Mater. 2008;15:53–76.
Ortega N, Behonick DJ, Werb Z. Matrix remodeling during endochondral ossification. Trends Cell Biol. 2004;14:86–93.
Olsen BR, Reginato AM, Want W. Bone development. Annu Rev Cell Dev Biol. 2000;16:191–220.
Dimitriou R, Tsiridis E, Giannoudis PV. Current concepts of molecular aspects of bone healing. Injury 2005;36:1392–1404.
Hunziker EB. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc Res Tech. 1994;28:505–519.
Khan SN, Cammisa FP, Harvinder SS, Diwan AD, Cirardi FP, Lane JM. The biology of bone grafting. J Am Acad Orthop Surg. 2005;13:77–86.
Hadjidakis DJ, Androulakis II. Bone remodeling. Ann N Y Acad Sci. 2006;1092:385–396.

MeSH Term

Animals
Bone Regeneration
Bone Transplantation
Bone and Bones
Humans
Plastic Surgery Procedures

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