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Journal of lipid research
Sep, 2012;53 (9): 1738-54.

PPAR-γ as a therapeutic target in cardiovascular disease: evidence and uncertainty.

Janice V Huang, Clifford R Greyson, Gregory G Schwartz
Author Information
  1. Janice V Huang: Cardiology Section, Denver VA Medical Center, US Department of Veterans Affairs, Denver, CO, USA.
PMID: 22685322 DOI: 10.1194/jlr.R024505

Abstract

Peroxisome proliferator-activated receptor γ (PPAR-γ) is a key regulator of fatty acid metabolism, promoting its storage in adipose tissue and reducing circulating concentrations of free fatty acids. Activation of PPAR-γ has favorable effects on measures of adipocyte function, insulin sensitivity, lipoprotein metabolism, and vascular structure and function. Despite these effects, clinical trials of thiazolidinedione PPAR-γ activators have not provided conclusive evidence that they reduce cardiovascular morbidity and mortality. The apparent disparity between effects on laboratory measurements and clinical outcomes may be related to limitations of clinical trials, adverse effects of PPAR-γ activation, or off-target effects of thiazolidinedione agents. This review addresses these issues from a clinician's perspective and highlights several ongoing clinical trials that may help to clarify the therapeutic role of PPAR-γ activators in cardiovascular disease.

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Grants

  1. R01 HL049944/NHLBI NIH HHS
  2. 5-R01-HL-049944/NHLBI NIH HHS

MeSH Term

Animals
Cardiovascular Diseases
Humans
Molecular Targeted Therapy
PPAR gamma
Uncertainty

Chemicals

PPAR gamma
Journal Article Research Support, N.I.H., Extramural Research Support, U.S. Gov't, Non-P.H.S. Review

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