As advances in life sciences and information technology bring profound influences on bioinformatics due to its interdisciplinary nature, bioinformatics is experiencing a new leap-forward from in-house computing infrastructure into utility-supplied cloud computing delivered over the Internet, in order to handle the vast quantities of biological data generated by high-throughput experimental technologies. Albeit relatively new, cloud computing promises to address big data storage and analysis issues in the bioinformatics field. Here we review extant cloud-based services in bioinformatics, classify them into Data as a Service (DaaS), Software as a Service (SaaS), Platform as a Service (PaaS), and Infrastructure as a Service (IaaS), and present our perspectives on the adoption of cloud computing in bioinformatics.
REVIEWERS: This article was reviewed by Frank Eisenhaber, Igor Zhulin, and Sandor Pongor.
Bioinformatics. 2008 Jan 15;24(2):299-301
[PMID:
18037613]
J Intern Med. 2012 Feb;271(2):122-30
[PMID:
22142244]
J Biomed Inform. 2010 Apr;43(2):342-53
[PMID:
19715773]
Brief Bioinform. 2009 Jan;10(1):1-10
[PMID:
18842678]
PLoS One. 2010 Apr 14;5(4):e10071
[PMID:
20418944]
Genome Biol. 2010;11(5):207
[PMID:
20441614]
BMC Bioinformatics. 2010 Dec 21;11 Suppl 12:S1
[PMID:
21210976]
Nat Biotechnol. 2011 Nov 08;29(11):972-4
[PMID:
22068528]
BMC Bioinformatics. 2011 Aug 30;12:356
[PMID:
21878105]
Nat Rev Genet. 2010 Sep;11(9):647-57
[PMID:
20717155]
Genome Med. 2010 Aug 06;2(8):51
[PMID:
20691073]
Bioinformatics. 2012 Mar 1;28(5):721-3
[PMID:
22257667]
Bioinformatics. 2012 Jan 15;28(2):294-5
[PMID:
22084254]
Genome Biol. 2009;10(11):R134
[PMID:
19930550]
Bioinformatics. 2012 Sep 1;28(17):2267-9
[PMID:
22743228]
Brief Bioinform. 2003 Sep;4(3):208-9
[PMID:
14582515]
BMC Bioinformatics. 2012 Mar 19;13:42
[PMID:
22429538]
BMC Bioinformatics. 2010 Dec 21;11 Suppl 12:S4
[PMID:
21210983]
Bioinformatics. 2012 Jun 1;28(11):1542-3
[PMID:
22492314]
Bioinformatics. 2009 Jun 1;25(11):1363-9
[PMID:
19357099]
Science. 2011 Jan 28;331(6016):406-7
[PMID:
21273473]
BMC Bioinformatics. 2010 May 18;11:259
[PMID:
20482786]
Bioinformatics. 2011 Apr 15;27(8):1045-51
[PMID:
21367868]
BMC Res Notes. 2011 Jun 06;4:171
[PMID:
21645377]
BMC Bioinformatics. 2011 May 09;12:139
[PMID:
21554709]
Nat Biotechnol. 2010 Jul;28(7):691-3
[PMID:
20622843]
Bioinformatics. 2012 Jun 1;28(11):1415-9
[PMID:
22556365]
Nat Biotechnol. 2012 Apr 10;30(4):295-6
[PMID:
22491260]
Bioinformatics. 2011 Mar 15;27(6):860-2
[PMID:
21252073]
Genome Biol. 2010;11(8):R83
[PMID:
20701754]
Nat Biotechnol. 2010 Nov;28(11):1181-5
[PMID:
21057489]
Nat Biotechnol. 2012 Jun 07;30(6):509-11
[PMID:
22678394]
PLoS Comput Biol. 2011 Aug;7(8):e1002147
[PMID:
21901085]
Nat Rev Genet. 2011 Mar;12(3):224
[PMID:
21301474]