OpenLB
Open Library of Bioscience
Advanced Search
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society
2014 Sep-Oct;22 (5): 569-78.

Clinical application of growth factors and cytokines in wound healing.

Stephan Barrientos, Harold Brem, Olivera Stojadinovic, Marjana Tomic-Canic
Author Information
  1. Stephan Barrientos: Division of Wound Healing and Regenerative Medicine, Department of Surgery, Winthrop University Hospital/Stony Brook University School of Medicine, Mineola, New York.
PMID: 24942811 DOI: 10.1111/wrr.12205

Abstract

Wound healing is a complex and dynamic biological process that involves the coordinated efforts of multiple cell types and is executed and regulated by numerous growth factors and cytokines. There has been a drive in the past two decades to study the therapeutic effects of various growth factors in the clinical management of nonhealing wounds (e.g., pressure ulcers, chronic venous ulcers, diabetic foot ulcers). For this review, we conducted an online search of Medline/PubMed and critically analyzed the literature regarding the role of growth factors and cytokines in the management of these wounds. We focused on currently approved therapies, emerging therapies, and future research possibilities. In this review, we discuss four growth factors and cytokines currently being used on and off label for the healing of wounds. These include granulocyte-macrophage colony-stimulating factor, platelet-derived growth factor, vascular endothelial growth factor, and basic fibroblast growth factor. While the clinical results of using growth factors and cytokines are encouraging, many studies involved a small sample size and are disparate in measured endpoints. Therefore, further research is required to provide definitive evidence of efficacy.

References

Ann Surg. 2002 Nov;236(5):684-92 [PMID: 12409676]
Am J Pathol. 2006 Sep;169(3):1080-7 [PMID: 16936280]
Plast Reconstr Surg. 1998 Jul;102(1):117-23 [PMID: 9655416]
J Am Coll Surg. 1996 Jul;183(1):61-4 [PMID: 8673309]
Br J Dermatol. 1998 Aug;139(2):239-46 [PMID: 9767237]
Mol Med. 2008 Sep-Oct;14(9-10):553-60 [PMID: 18548133]
Br J Dermatol. 2010 Mar;162(3):478-86 [PMID: 19799605]
Br J Cancer. 1998 Mar;77(6):956-64 [PMID: 9528841]
Am J Surg. 2001 Jan;181(1):81-6 [PMID: 11248182]
Wound Repair Regen. 2000 Jan-Feb;8(1):36-44 [PMID: 10760213]
Am J Pathol. 1998 Jun;152(6):1445-52 [PMID: 9626049]
J Intern Med. 1994 Nov;236(5):487-93 [PMID: 7964423]
J Invest Dermatol. 2004 Mar;122(3):764-72 [PMID: 15086564]
Exp Cell Res. 2007 May 15;313(9):1758-77 [PMID: 17449030]
Am J Physiol. 1994 Oct;267(4 Pt 2):H1263-71 [PMID: 7943370]
J Eur Acad Dermatol Venereol. 2002 Nov;16(6):595-8 [PMID: 12482042]
Diabetes Care. 1998 May;21(5):822-7 [PMID: 9589248]
Wound Repair Regen. 2009 Sep-Oct;17(5):685-9 [PMID: 19769721]
Haematologica. 1990 Nov-Dec;75(6):551-4 [PMID: 2098298]
J Biol Chem. 1996 Nov 15;271(46):29393-9 [PMID: 8910604]
Endocr Relat Cancer. 2000 Sep;7(3):165-97 [PMID: 11021964]
J Dermatol. 1992 Nov;19(11):664-6 [PMID: 1293151]
Front Biosci. 2007 May 01;12:2849-68 [PMID: 17485264]
Wound Repair Regen. 2000 Jan-Feb;8(1):13-25 [PMID: 10760211]
J Biol Chem. 2007 Mar 2;282(9):6001-11 [PMID: 17200110]
Br J Surg. 2003 Feb;90(2):133-46 [PMID: 12555288]
Lancet. 1997 Sep 20;350(9081):855-9 [PMID: 9310604]
World J Surg. 2009 Jul;33(7):1396-402 [PMID: 19424752]
Am J Surg. 2010 Oct;200(4):473-7 [PMID: 20887840]
J Invest Dermatol. 2003 Apr;120(4):683-92 [PMID: 12648235]
Br J Dermatol. 2007 Sep;157(3):458-65 [PMID: 17553038]
Wound Repair Regen. 2011 Sep-Oct;19(5):542-51 [PMID: 22092792]
Forensic Sci Int. 2000 Sep 11;113(1-3):251-64 [PMID: 10978634]
J Invest Dermatol. 1993 Jul;101(1):64-8 [PMID: 8392530]
Nat Med. 2000 Oct;6(10):1102-3 [PMID: 11017137]
Mol Med. 2007 Jan-Feb;13(1-2):30-9 [PMID: 17515955]
Int J Dermatol. 1999 May;38(5):380-6 [PMID: 10369552]
Pharm Dev Technol. 1997 May;2(2):171-80 [PMID: 9552443]
Wound Repair Regen. 1999 Sep-Oct;7(5):335-46 [PMID: 10564562]
Wound Repair Regen. 2006 Jul-Aug;14(4):457-62 [PMID: 16939574]
Wound Repair Regen. 1996 Oct;4(4):411-20 [PMID: 17309691]
Adv Skin Wound Care. 2003 Sep-Oct;16(5):246-57; quiz 258-9 [PMID: 14581817]
Wound Repair Regen. 1997 Jan-Mar;5(1):12-7 [PMID: 16984452]
Am J Pathol. 1996 Jul;149(1):293-305 [PMID: 8686754]
Physiol Rev. 1999 Oct;79(4):1283-316 [PMID: 10508235]
Wound Repair Regen. 1997 Jan-Mar;5(1):23-32 [PMID: 16984454]
Invest Ophthalmol Vis Sci. 1998 May;39(6):1028-35 [PMID: 9579483]
Diabetes Obes Metab. 2001 Oct;3(5):332-7 [PMID: 11703423]
Circulation. 1994 Nov;90(5 Pt 2):II228-34 [PMID: 7525111]
Am J Physiol. 1996 Jan;270(1 Pt 2):H411-5 [PMID: 8769777]
Ann Plast Surg. 1992 Sep;29(3):193-201 [PMID: 1524367]
Am J Pathol. 1997 Aug;151(2):479-92 [PMID: 9250160]
Blood. 1992 Sep 1;80(5):1149-57 [PMID: 1515637]
J Cell Biol. 2006 Jan 30;172(3):423-32 [PMID: 16449192]
Diabetes Care. 1995 Jan;18(1):64-9 [PMID: 7698050]
J Transl Med. 2008 Dec 01;6:75 [PMID: 19046453]
Science. 1997 Jul 11;277(5323):242-5 [PMID: 9211853]
Arch Surg. 1996 Jun;131(6):660-6 [PMID: 8645076]
J Vasc Surg. 1995 Jan;21(1):71-8; discussion 79-81 [PMID: 7823364]
Bone Marrow Transplant. 2002 May;29(10):825-32 [PMID: 12058232]
Cancer Sci. 2008 May;99(5):1021-8 [PMID: 18380792]
Ann Surg. 1992 Oct;216(4):401-6; discussion 406-8 [PMID: 1417189]
Leukemia. 1993 Oct;7(10):1491-5 [PMID: 7692189]
Wound Repair Regen. 1999 Jan-Feb;7(1):17-25 [PMID: 10231502]
Wound Repair Regen. 2008 Sep-Oct;16(5):585-601 [PMID: 19128254]
J Exp Med. 1992 Jun 1;175(6):1717-28 [PMID: 1588289]
J Trauma. 1995 Dec;39(6):1141-6; discussion 1146-7 [PMID: 7500409]
J Vasc Surg. 1995 Feb;21(2):314-24; discussion 324-5 [PMID: 7531786]
FEBS Lett. 1996 May 13;386(1):82-6 [PMID: 8635609]
Oncogene. 1997 May 1;14(17):2025-32 [PMID: 9160882]
Wound Repair Regen. 1999 May-Jun;7(3):141-7 [PMID: 10417749]
Lancet. 1998 Nov 21;352(9141):1661-4 [PMID: 9853438]
Am J Health Syst Pharm. 1995 Jun 1;52(11):1199-207; quiz 1239-40 [PMID: 7656109]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2010 Jun;24(6):643-6 [PMID: 20632489]
Br J Dermatol. 2006 Jan;154(1):34-41 [PMID: 16403091]
Free Radic Biol Med. 2006 Apr 1;40(7):1250-63 [PMID: 16545694]
Blood. 1997 Nov 15;90(10):4153-61 [PMID: 9354686]
J Cardiovasc Pharmacol. 1996 Jan;27(1):91-8 [PMID: 8656665]
Zhonghua Shao Shang Za Zhi. 2008 Apr;24(2):107-10 [PMID: 18785409]
Wound Repair Regen. 1999 May-Jun;7(3):148-53 [PMID: 10417750]
Wound Repair Regen. 2005 Nov-Dec;13(6):531-6 [PMID: 16283867]
Mol Ther. 2009 Oct;17(10):1822-9 [PMID: 19638959]
J Clin Invest. 1994 Feb;93(2):662-70 [PMID: 7509344]
Ostomy Wound Manage. 2003 Oct;49(10):42-50 [PMID: 14652420]
Eur J Dermatol. 2009 Sep-Oct;19(5):461-8 [PMID: 19638336]
Ann Plast Surg. 2004 Jan;52(1):80-8 [PMID: 14676705]
J Exp Med. 1992 Nov 1;176(5):1375-9 [PMID: 1402682]
Arch Surg. 1994 Feb;129(2):213-9 [PMID: 8304833]
Arch Dermatol Res. 1999 Jul-Aug;291(7-8):400-4 [PMID: 10482009]
Cytokine. 2009 Jan;45(1):20-5 [PMID: 19019696]
J Surg Res. 2002 Sep;107(1):124-30 [PMID: 12384074]
Hum Gene Ther. 2006 Jun;17(6):683-91 [PMID: 16776576]
Am J Pathol. 2004 Jun;164(6):1935-47 [PMID: 15161630]
Lab Invest. 1993 Nov;69(5):508-17 [PMID: 8246443]
J Invest Dermatol. 2001 Dec;117(6):1382-90 [PMID: 11886498]
Surg Today. 2006;36(1):47-51 [PMID: 16378193]
Virchows Arch B Cell Pathol Incl Mol Pathol. 1991;60(2):73-82 [PMID: 1675512]
J Wound Care. 2008 Jan;17(1):30-2, 34-7 [PMID: 18210954]
Wound Repair Regen. 2000 Nov-Dec;8(6):460-72 [PMID: 11208173]
J Invest Dermatol. 1996 Nov;107(5):743-8 [PMID: 8875960]
Metabolism. 2005 Oct;54(10):1290-6 [PMID: 16154426]
Wound Repair Regen. 2002 Nov-Dec;10(6):354-9 [PMID: 12453138]
J Exp Med. 2002 Dec 2;196(11):1497-506 [PMID: 12461084]
Int J Crit Illn Inj Sci. 2013 Oct;3(4):279-81 [PMID: 24459628]
J Invest Dermatol. 1995 Feb;104(2):236-40 [PMID: 7829879]
Am J Surg. 1997 Mar;173(3):165-8 [PMID: 9124619]
Mol Med. 2010 Mar;16(3-4):92-101 [PMID: 20069132]
Wound Repair Regen. 2006 May-Jun;14(3):259-64 [PMID: 16808804]
Ann Surg. 2000 Apr;231(4):600-11 [PMID: 10749622]
J Am Coll Surg. 2008 Dec;207(6):e1-6 [PMID: 19183519]
J Infect. 1997 Sep;35(2):179-82 [PMID: 9354355]
Biomaterials. 2006 Nov;27(33):5708-14 [PMID: 16901540]
Biochem Biophys Res Commun. 1992 Dec 15;189(2):824-31 [PMID: 1281999]
Mol Biol Cell. 1992 Feb;3(2):211-20 [PMID: 1550962]
J Vasc Surg. 1991 Oct;14(4):526-32; discussion 532-6 [PMID: 1920650]
Wound Repair Regen. 2001 Sep-Oct;9(5):347-52 [PMID: 11896977]

Grants

  1. K24 DK090135/NIDDK NIH HHS
  2. R01 NR013881/NINR NIH HHS
  3. R01NR013881/NINR NIH HHS
  4. K24DK90135/NIDDK NIH HHS

MeSH Term

Diabetic Foot
Fibroblast Growth Factor 2
Granulocyte-Macrophage Colony-Stimulating Factor
Humans
Platelet-Derived Growth Factor
Pressure Ulcer
Varicose Ulcer
Vascular Endothelial Growth Factor A
Wound Healing

Chemicals

Platelet-Derived Growth Factor
Vascular Endothelial Growth Factor A
Fibroblast Growth Factor 2
Granulocyte-Macrophage Colony-Stimulating Factor
Journal Article Research Support, N.I.H., Extramural Review

Word Cloud

Similar Articles

Cited By