Abbas Khani, Mojtaba Kermani, Soghra Hesam, Abbas Haghparast, Enrike G Argandoña, Gregor Rainer
Despite the evidence for altered decision making in cannabis abusers, the role of the cannabinoid system in decision-making circuits has not been studied. Here, we examined the effects of cannabinoid modulation during cost-benefit decision making in the anterior cingulate cortex (ACC) and orbitofrontal cortex (OFC), key brain areas involved in decision making. We trained different groups of rats in a delay-based and an effort-based form of cost-benefit T-maze decision-making task. During test days, the rats received local injections of either vehicle or ACEA, a cannabinoid type-1 receptor (CB1R) agonist in the ACC or OFC. We measured spontaneous locomotor activity following the same treatments and characterized CB1Rs localization on different neuronal populations within these regions using immunohistochemistry. We showed that CB1R activation in the ACC impaired decision making such that rats were less willing to invest physical effort to gain high reward. Similarly, CB1R activation in the OFC induced impulsive pattern of choice such that rats preferred small immediate rewards to large delayed rewards. Control tasks ensured that the effects were specific for differential cost-benefit tasks. Furthermore, we characterized widespread colocalizations of CB1Rs on GABAergic axonal ends but few colocalizations on glutamatergic, dopaminergic, and serotonergic neuronal ends. These results provide first direct evidence that the cannabinoid system plays a critical role in regulating cost-benefit decision making in the ACC and OFC and implicate cannabinoid modulation of synaptic ends of predominantly interneurons and to a lesser degree other neuronal populations in these two frontal regions.
Neuropsychopharmacology. 2005 Apr;30(4):800-9
[PMID:
15775958]
Psychopharmacology (Berl). 2005 May;179(3):587-96
[PMID:
15864561]
PLoS One. 2011;6(10):e26167
[PMID:
22022550]
Cereb Cortex. 2009 Jul;19(7):1678-86
[PMID:
19029064]
J Neurosci. 2007 Aug 1;27(31):8170-3
[PMID:
17670961]
Psychopharmacology (Berl). 2013 Mar;226(2):307-19
[PMID:
23138434]
Physiol Rev. 2009 Jan;89(1):309-80
[PMID:
19126760]
Biol Pharm Bull. 2002 Dec;25(12):1570-6
[PMID:
12499642]
Cereb Cortex. 2009 Oct;19(10):2240-7
[PMID:
19131436]
Handb Exp Pharmacol. 2012;(209):357-81
[PMID:
22249824]
Pain. 2013 Jan;154(1):124-34
[PMID:
23273106]
Nat Med. 2008 Sep;14(9):923-30
[PMID:
18776886]
Neuroscience. 1992;48(3):655-68
[PMID:
1376455]
J Comp Neurol. 2000 Jun 26;422(2):159-71
[PMID:
10842224]
Behav Neurosci. 2005 Feb;119(1):323-8
[PMID:
15727537]
Neuron. 2008 Mar 27;57(6):883-93
[PMID:
18367089]
Drug Alcohol Depend. 2012 Feb 1;121(1-2):159-62
[PMID:
21920674]
Trends Neurosci. 2003 Dec;26(12):676-82
[PMID:
14624852]
Neuron. 2012 Oct 4;76(1):70-81
[PMID:
23040807]
Behav Brain Res. 2013 Mar 15;241:214-21
[PMID:
23261877]
Neuroscience. 1998 Mar;83(2):393-411
[PMID:
9460749]
Behav Pharmacol. 2011 Aug;22(4):335-46
[PMID:
21558844]
Subst Use Misuse. 2014 Mar;49(4):427-34
[PMID:
24093525]
Trends Cogn Sci. 2007 Apr;11(4):168-76
[PMID:
17337237]
Neurosci Biobehav Rev. 2006;30(5):680-95
[PMID:
16574226]
Pharmacol Biochem Behav. 2008 Oct;90(4):501-11
[PMID:
18584858]
Nat Neurosci. 2011 Oct 30;14(12):1581-9
[PMID:
22037498]
J Neurosci. 2006 Mar 15;26(11):2991-3001
[PMID:
16540577]
Brain Res. 1998 May 18;793(1-2):7-11
[PMID:
9630477]
Neuron. 2013 Jan 9;77(1):155-67
[PMID:
23312523]
Neurosci Biobehav Rev. 2014 May;42:116-31
[PMID:
24582908]
Nat Neurosci. 2006 Dec;9(12):1526-33
[PMID:
17115043]
J Neurosci. 2005 Jul 20;25(29):6845-56
[PMID:
16033894]
Psychopharmacology (Berl). 2010 Jul;211(1):87-98
[PMID:
20428999]
Behav Pharmacol. 2009 Sep;20(5-6):415-23
[PMID:
19730369]
Pharmacol Biochem Behav. 2013 May;106:91-100
[PMID:
23541493]
Neurobiol Learn Mem. 2012 Jul;98(1):47-55
[PMID:
22579951]
Neural Netw. 2006 Oct;19(8):1302-14
[PMID:
16949252]
Psychopharmacology (Berl). 2008 Mar;196 (4):565-74
[PMID:
18004546]
Brain Res. 1999 Mar 20;822(1-2):237-42
[PMID:
10082902]
Cereb Cortex. 2000 Mar;10(3):220-42
[PMID:
10731218]
Neuropsychopharmacology. 2003 Jul;28(7):1356-65
[PMID:
12784123]
Cereb Cortex. 2000 Mar;10(3):295-307
[PMID:
10731224]
Psychopharmacology (Berl). 2012 Jan;219(2):575-86
[PMID:
21938415]
Behav Brain Res. 1994 Dec 15;65(2):221-9
[PMID:
7718155]
Neuropsychopharmacology. 2005 Oct;30(10):1895-905
[PMID:
15812570]
Brain Res Brain Res Rev. 2000 Mar;31(2-3):330-41
[PMID:
10719160]
Neuroscience. 2006;137(1):337-61
[PMID:
16289348]
Nat Neurosci. 2013 Aug;16(8):1068-76
[PMID:
23817549]
Nature. 2013 Nov 28;503(7477):521-4
[PMID:
24097352]
Learn Mem. 2006 Nov-Dec;13(6):777-82
[PMID:
17142306]
Eur Addict Res. 2009;15(2):94-8
[PMID:
19142009]
Learn Mem. 2005 May-Jun;12(3):334-42
[PMID:
15930509]
Biol Psychiatry. 2011 Jun 15;69(12):1185-91
[PMID:
21353665]
Neuropharmacology. 2007 Mar;52(3):958-65
[PMID:
17156799]
Nat Methods. 2012 Jun 28;9(7):676-82
[PMID:
22743772]
Twin Res Hum Genet. 2007 Dec;10(6):805-11
[PMID:
18179391]
Prog Brain Res. 1990;85:31-62
[PMID:
2094901]
Biol Psychiatry. 2014 Mar 15;75(6):487-98
[PMID:
24138924]
Cereb Cortex. 2007 Jan;17(1):175-91
[PMID:
16467563]
Nat Neurosci. 2006 Sep;9(9):1161-8
[PMID:
16921368]
Prog Neuropsychopharmacol Biol Psychiatry. 2004 Mar;28(2):355-60
[PMID:
14751433]
J Neural Transm (Vienna). 2007;114(12 ):1519-28
[PMID:
17616844]
J Neurosci. 2010 May 26;30(21):7236-48
[PMID:
20505090]
Nat Neurosci. 2013 Feb;16(2):210-8
[PMID:
23313910]
J Neurosci. 2010 Oct 20;30(42):14080-90
[PMID:
20962229]
Alcohol Clin Exp Res. 2012 Dec;36(12):2104-9
[PMID:
22551199]
Drug Alcohol Depend. 2012 Aug 1;124(3):355-62
[PMID:
22425410]
Psychopharmacology (Berl). 2007 Jul;193(1):85-96
[PMID:
17387457]
J Neurosci. 2006 May 24;26(21):5794-9
[PMID:
16723537]
Front Integr Neurosci. 2014 Jan 03;7:104
[PMID:
24427123]
Mol Brain. 2009 Oct 15;2:32
[PMID:
19828050]
Biol Psychiatry. 2013 May 1;73(9):895-903
[PMID:
23237313]
J Neurosci. 2009 Sep 9;29(36):11078-88
[PMID:
19741114]
Neuropsychopharmacology. 2010 Mar;35(4):967-75
[PMID:
20010552]
J Neurophysiol. 2014 May;111(9):1717-20
[PMID:
24401706]
PLoS Biol. 2007 Oct;5(10):e269
[PMID:
17927447]
J Comp Neurol. 1989 Dec 8;290(2):213-42
[PMID:
2592611]
Trends Neurosci. 2007 May;30(5):220-7
[PMID:
17400299]
PLoS One. 2011;6(10 ):e25856
[PMID:
22016780]
Cogn Affect Behav Neurosci. 2012 Mar;12(1):74-84
[PMID:
22012275]
Drug Alcohol Depend. 2004 Oct 5;76(1):107-11
[PMID:
15380295]
Neuropharmacology. 2012 Aug;63(2):202-10
[PMID:
22691536]
