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PloS one
2015;10 (6): e0130530.

Homozygous Wildtype of XPD K751Q Polymorphism Is Associated with Increased Risk of Nasopharyngeal Carcinoma in Malaysian Population.

Munn-Sann Lye, Shaneeta Visuvanathan, Pei-Pei Chong, Yoke-Yeow Yap, Chin-Chye Lim, Eng-Zhuan Ban
Author Information
  1. Munn-Sann Lye: Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  2. Shaneeta Visuvanathan: Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  3. Pei-Pei Chong: Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  4. Yoke-Yeow Yap: Department of Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
  5. Chin-Chye Lim: National Cancer Institute, Ministry of Health Malaysia, Putrajaya, Malaysia.
  6. Eng-Zhuan Ban: Department of Community Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
PMID: 26086338 DOI: 10.1371/journal.pone.0130530

Abstract

The xeroderma pigmentosum group D (XPD) gene encodes a DNA helicase, an important component in transcription factor IIH (TFIIH) complex. XPD helicase plays a pivotal role in unwinding DNA at the damaged region during nucleotide excision repair (NER) mechanism. Dysfunctional XPD helicase protein from polymorphic diversity may contribute to increased risk of developing cancers. This study aims to determine the association between XPD K751Q polymorphism (rs13181) and risk of nasopharyngeal carcinoma (NPC) in the Malaysian population. In this hospital-based matched case-control study, 356 controls were matched by age, gender and ethnicity to 356 cases. RFLP-PCR was used to genotype the XPD K751Q polymorphism. A significant association was observed between XPD K751Q polymorphism and the risk of NPC using conditional logistic regression. Subjects with homozygous Lys/Lys (wildtype) genotype have 1.58 times higher odds of developing NPC compared to subjects with recessive combination of heterozygous Lys/Gln and homozygous Gln/Gln genotypes (OR = 1.58, 95% CI = 1.05-2.38 p = 0.028) adjusted for cigarette smoking, alcohol and salted fish consumption. Our data suggests that Lys/Lys (wildtype) of XPD K751Q contributes to increased risk of NPC in the Malaysian population.

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MeSH Term

Adult
Aged
Alleles
Asian People
Carcinoma
Case-Control Studies
Female
Gene Frequency
Genotype
Homozygote
Humans
Malaysia
Male
Middle Aged
Nasopharyngeal Neoplasms
Odds Ratio
Polymorphism, Single Nucleotide
Risk Factors
Xeroderma Pigmentosum Group D Protein

Chemicals

Xeroderma Pigmentosum Group D Protein
Journal Article Research Support, Non-U.S. Gov't

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