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Experimental and therapeutic medicine
Nov, 2015;10 (5): 1615-1623.

Biological and therapeutic activities, and anticancer properties of curcumin.

Donatella Perrone, Fatima Ardito, Giovanni Giannatempo, Mario Dioguardi, Giuseppe Troiano, Lucio Lo Russo, Alfredo DE Lillo, Luigi Laino, Lorenzo Lo Muzio
Author Information
  1. Donatella Perrone: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  2. Fatima Ardito: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  3. Giovanni Giannatempo: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  4. Mario Dioguardi: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  5. Giuseppe Troiano: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  6. Lucio Lo Russo: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  7. Alfredo DE Lillo: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  8. Luigi Laino: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
  9. Lorenzo Lo Muzio: Department of Clinical and Experimental Medicine, Foggia University, Foggia 71122, Italy.
PMID: 26640527 DOI: 10.3892/etm.2015.2749

Abstract

Curcumin (diferuloylmethane) is a polyphenol derived from the plant. Curcumin has been used extensively in Ayurvedic medicine, as it is nontoxic and exhibits a variety of therapeutic properties, including antioxidant, analgesic, anti-inflammatory and antiseptic activities. Recently, certain studies have indicated that curcumin may exert anticancer effects in a variety of biological pathways involved in mutagenesis, apoptosis, tumorigenesis, cell cycle regulation and metastasis. The present study reviewed previous studies in the literature, which support the therapeutic activity of curcumin in cancer. In addition, the present study elucidated a number of the challenges concerning the use of curcumin as an adjuvant chemotherapeutic agent. All the studies reviewed herein suggest that curcumin is able to exert anti-inflammatory, antiplatelet, antioxidative, hepatoprotective and antitumor activities, particularly against cancers of the liver, skin, pancreas, prostate, ovary, lung and head neck, as well as having a positive effect in the treatment of arthritis.

Keywords

anti-inflammatory activity anticancer agents cancer curcumin nutraceutical

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