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Health affairs (Project Hope)
05 01, 2016;35 (5): 798-804.

Despite Federal Legislation, Shortages Of Drugs Used In Acute Care Settings Remain Persistent And Prolonged.

Serene I Chen, Erin R Fox, M Kennedy Hall, Joseph S Ross, Emily M Bucholz, Harlan M Krumholz, Arjun K Venkatesh
Author Information
  1. Serene I Chen: Serene I. Chen is an emergency medicine resident at Highland Hospital, in Oakland, California. She was a student at the Yale School of Medicine when this research was conducted.
  2. Erin R Fox: Erin R. Fox is director of the Drug Information Service at University of Utah Health Care, in Salt Lake City.
  3. M Kennedy Hall: M. Kennedy Hall is an acting instructor in the Division of Emergency Medicine at the University of Washington, in Seattle. He was a fellow in the Department of Emergency Medicine at the Yale School of Medicine when this research was conducted.
  4. Joseph S Ross: Joseph S. Ross is an associate professor in the Department of Internal Medicine at the Yale School of Medicine, in New Haven, Connecticut.
  5. Emily M Bucholz: Emily M. Bucholz is a resident physician at Boston Children's Hospital, in Massachusetts. She was a student at the Yale School of Medicine when this research was conducted.
  6. Harlan M Krumholz: Harlan M. Krumholz is the Harold H. Hines, Jr. Professor of Medicine and Epidemiology and Public Health at the Yale School of Medicine.
  7. Arjun K Venkatesh: Arjun K. Venkatesh (arjun.venkatesh@yale.edu) is an assistant professor in the Department of Emergency Medicine at the Yale School of Medicine.
PMID: 27140985 DOI: 10.1377/hlthaff.2015.1157

Abstract

Early evidence suggests that provisions of the Food and Drug Administration Safety and Innovation Act of 2012 are associated with reductions in the total number of new national drug shortages. However, drugs frequently used in acute unscheduled care such as the care delivered in emergency departments may be increasingly affected by shortages. Our estimates, based on reported national drug shortages from 2001 to 2014 collected by the University of Utah's Drug Information Service, show that although the number of new annual shortages has decreased since the act's passage, half of all drug shortages in the study period involved acute care drugs. Shortages affecting acute care drugs became increasingly frequent and prolonged compared with non-acute care drugs (median duration of 242 versus 173 days, respectively). These results suggest that the drug supply for many acutely and critically ill patients in the United States remains vulnerable despite federal efforts.

Keywords

Access To Care FDA Legal/Regulatory Issues Pharmaceuticals

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Grants

  1. L30 GM102930/NIGMS NIH HHS
  2. P01 DK043881/NIDDK NIH HHS
  3. U01 HL105270/NHLBI NIH HHS

MeSH Term

Critical Illness
Drug Industry
Drug Substitution
Emergency Service, Hospital
Federal Government
Humans
Prescription Drugs
Time Factors
United States
United States Food and Drug Administration

Chemicals

Prescription Drugs
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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