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Antimicrobial agents and chemotherapy
10, 2016;60 (10): 6390-2.

Characterization of Spectinomycin Resistance in Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism.

Kaisong Huang, Qiang Zhang, Yajing Song, Zhewen Zhang, Anding Zhang, Jingfa Xiao, Meilin Jin
Author Information
  1. Kaisong Huang: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
  2. Qiang Zhang: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
  3. Yajing Song: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
  4. Zhewen Zhang: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  5. Anding Zhang: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
  6. Jingfa Xiao: CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
  7. Meilin Jin: State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China jml8328@126.com.
PMID: 27458226 DOI: 10.1128/AAC.01157-16

Abstract

Spectinomycin is an aminocyclitol antibiotic used clinically to treat a variety of infections in animals. Here, we characterized drug resistance prevalence in clinical Streptococcus suis isolates and discovered a novel resistance mechanism in which the s5 mutation (Gly26Asp) results in high spectinomycin resistance. Additionally, a novel integrative and conjugative element encompassing a multidrug resistance spw_like-aadE-lnu(B)-lsa(E) cluster and a cadmium resistance operon were identified, suggesting a possible cause for the wide dissemination of spectinomycin resistance in S. suis.

References

Vet Microbiol. 2009 Oct 20;139(1-2):80-8 [PMID: 19447571]
Antimicrob Agents Chemother. 2012 Sep;56(9):4697-702 [PMID: 22710115]
Vet Microbiol. 2006 Mar 10;113(1-2):73-82 [PMID: 16387456]
Antimicrob Agents Chemother. 2015 Nov;59(11):7113-6 [PMID: 26324271]
Vet Microbiol. 2015 May 15;177(1-2):162-7 [PMID: 25759293]
Antimicrob Agents Chemother. 2014;58(3):1785-8 [PMID: 24366733]
Front Microbiol. 2011 Nov 25;2:235 [PMID: 22275909]
J Antimicrob Chemother. 2000 Jul;46(1):87-9 [PMID: 10882694]
J Antimicrob Chemother. 2014 May;69(5):1424-6 [PMID: 24379302]
J Antimicrob Chemother. 2013 Jul;68(7):1679-80 [PMID: 23511231]
BMC Genomics. 2011 Oct 25;12:523 [PMID: 22026465]
Berl Munch Tierarztl Wochenschr. 2007 Sep-Oct;120(9-10):363-71 [PMID: 17939451]
J Antimicrob Chemother. 2014 Jul;69(7):2000-3 [PMID: 24648508]
Antimicrob Agents Chemother. 2005 Jul;49(7):3046-9 [PMID: 15980396]
Antimicrob Agents Chemother. 1991 Sep;35(9):1804-10 [PMID: 1659306]
J Bacteriol. 2009 Apr;191(7):2257-65 [PMID: 19168609]

MeSH Term

Anti-Bacterial Agents
Bacterial Proteins
Cadmium
China
Drug Resistance, Bacterial
Microbial Sensitivity Tests
Multigene Family
Mutation
Operon
RNA, Ribosomal, 16S
Ribosomal Proteins
Spectinomycin
Streptococcus suis

Chemicals

Anti-Bacterial Agents
Bacterial Proteins
RNA, Ribosomal, 16S
Ribosomal Proteins
Cadmium
Spectinomycin
Journal Article Research Support, Non-U.S. Gov't

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