Swine Influenza A Viruses (swIAVs) have been shown to persist in farrow-to-finish pig herds with repeated outbreaks in successive batches, increasing the risk for respiratory disorders in affected animals and being a threat for public health. Although the general routes of swIAV transmission (i.e. direct contact and exposure to aerosols) were clearly identified, the transmission process between batches is still not fully understood. Maternally derived antibodies (MDAs) were stressed as a possible factor favoring within-herd swIAV persistence. However, the relationship between MDAs and the global spread among the different subpopulations in the herds is still lacking. The aim of this study was therefore to understand the mechanisms induced by MDAs in relation with swIAV spread and persistence in farrow-to-finish pig herds. A metapopulation model has been developed representing the population dynamics considering two subpopulations-breeding sows and growing pigs-managed according to batch-rearing system. This model was coupled with a swIAV-specific epidemiological model, accounting for partial passive immunity protection in neonatal piglets and an immunity boost in re-infected animals. Airborne transmission was included by a between-room transmission rate related to the current prevalence of shedding pigs. Maternally derived partial immunity in piglets was found to extend the duration of the epidemics within their batch, allowing for efficient between-batch transmission and resulting in longer swIAV persistence at the herd level. These results should be taken into account in the design of control programmes for the spread and persistence of swIAV in swine herds.
Zoonoses Public Health. 2013 Sep;60(6):383-411
[PMID:
22937896]
Proc Biol Sci. 2001 May 7;268(1470):985-93
[PMID:
11370974]
PLoS One. 2015 Jun 15;10(6):e0129213
[PMID:
26076494]
J Virol. 2012 Jun;86(12):6804-14
[PMID:
22491461]
Vet Res. 2013 Sep 04;44:72
[PMID:
24007505]
Vet Microbiol. 2011 Apr 21;149(1-2):56-63
[PMID:
21112702]
Vet Immunol Immunopathol. 2003 Mar 20;92(1-2):23-35
[PMID:
12628761]
PLoS One. 2010 Feb 26;5(2):e9371
[PMID:
20195473]
Prev Vet Med. 2009 Nov 1;92(1-2):38-51
[PMID:
19720410]
Transbound Emerg Dis. 2014 Feb;61(1):28-36
[PMID:
22827737]
Vet Microbiol. 2000 May 22;74(1-2):29-46
[PMID:
10799776]
Vet Res. 2016 Aug 17;47(1):86
[PMID:
27530456]
Animal. 2008 Jan;2(1):105-16
[PMID:
22444969]
Emerg Infect Dis. 2011 Jun;17 (6):1049-52
[PMID:
21749767]
PLoS One. 2014 Aug 27;9(8):e106177
[PMID:
25162536]
J R Soc Interface. 2016 Jun;13(119):null
[PMID:
27358277]
Vet Immunol Immunopathol. 2006 Aug 15;112(3-4):117-28
[PMID:
16621020]
Arch Virol. 2012 Mar;157(3):555-62
[PMID:
22198410]
Prev Vet Med. 1998 Apr 16;35(1):53-72
[PMID:
9638780]
Viruses. 2015 Oct 12;7(10):5274-304
[PMID:
26473911]
Prev Vet Med. 2003 Nov 12;61(3):209-25
[PMID:
14554144]
Prev Vet Med. 2010 Mar 1;93(4):248-57
[PMID:
20004990]
J Virol. 2012 Oct;86(19):10597-605
[PMID:
22811541]
Transbound Emerg Dis. 2012 Mar;59 Suppl 1:68-84
[PMID:
22226050]
Vet Immunol Immunopathol. 2011 Jul 15;142(1-2):81-6
[PMID:
21501880]
Int J Food Microbiol. 1996 Jun;30(1-2):37-53
[PMID:
8856373]
PLoS Med. 2005 Jul;2(7):e174
[PMID:
16013892]
Vet Microbiol. 2013 Mar 23;162(2-4):543-50
[PMID:
23201246]
Zoonoses Public Health. 2009 Aug;56(6-7):326-37
[PMID:
19486316]
J Anim Sci. 2001 Aug;79(8):2047-56
[PMID:
11518212]
Vaccine. 2013 Jan 7;31(3):500-5
[PMID:
23174202]
Math Biosci. 2010 May;225(1):24-35
[PMID:
20102724]
Vet Res. 2012 Mar 27;43:24
[PMID:
22452923]
Virus Res. 2012 Oct;169(1):175-81
[PMID:
22906589]
