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Journal of immunology (Baltimore, Md. : 1950)
12 15, 2016;197 (12): 4509-4517.

Biogenesis and Transcriptional Regulation of Long Noncoding RNAs in the Human Immune System.

Charles F Spurlock, Philip S Crooke, Thomas M Aune
Author Information
  1. Charles F Spurlock: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and. ORCID
  2. Philip S Crooke: Department of Mathematics, Vanderbilt University, Nashville, TN 37232. ORCID
  3. Thomas M Aune: Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232; and tom.aune@vanderbilt.edu. ORCID
PMID: 27913643 DOI: 10.4049/jimmunol.1600970

Abstract

The central dogma of molecular biology states that DNA makes RNA makes protein. Discoveries over the last quarter of a century found that the process of DNA transcription into RNA gives rise to a diverse array of functional RNA species, including genes that code for protein and noncoding RNAs. For decades, the focus has been on understanding how protein-coding genes are regulated to influence protein expression. However, with the completion of the Human Genome Project and follow-up ENCODE data, it is now appreciated that only 2-3% of the genome codes for protein-coding gene exons and that the bulk of the transcribed genome, apart from ribosomal RNAs, is at the level of noncoding RNA genes. In this article, we focus on the biogenesis and regulation of a distinct class of noncoding RNA molecules termed long, noncoding RNAs in the context of the immune system.

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Grants

  1. R01 AI044924/NIAID NIH HHS
  2. R43 AI124766/NIAID NIH HHS

MeSH Term

Animals
Chromatin Assembly and Disassembly
Gene Expression Regulation
Genome
Humans
Immune System
RNA, Long Noncoding
Transcription, Genetic

Chemicals

RNA, Long Noncoding
Journal Article Review Research Support, N.I.H., Extramural

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