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Journal of immunology (Baltimore, Md. : 1950)
09 01, 2017;199 (5): 1696-1705.

Adaptive from Innate: Human IFN-γCD4 T Cells Can Arise Directly from CXCL8-Producing Recent Thymic Emigrants in Babies and Adults.

Abhishek Das, Kevin Rouault-Pierre, Shraddha Kamdar, Iria Gomez-Tourino, Kristie Wood, Ian Donaldson, Charles A Mein, Dominique Bonnet, Adrian C Hayday, Deena L Gibbons
Author Information
  1. Abhishek Das: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  2. Kevin Rouault-Pierre: The Francis Crick Institute, London NW1 1AT, United Kingdom. ORCID
  3. Shraddha Kamdar: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  4. Iria Gomez-Tourino: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  5. Kristie Wood: National Institute for Health Research Biomedical Research Centre Genomics Research Platform, Guy's Hospital, London SE1 9RT, United Kingdom; and.
  6. Ian Donaldson: Genome Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London EC1M 6BQ, United Kingdom.
  7. Charles A Mein: Genome Centre, Barts and the London School of Medicine and Dentistry, John Vane Science Centre, London EC1M 6BQ, United Kingdom.
  8. Dominique Bonnet: The Francis Crick Institute, London NW1 1AT, United Kingdom.
  9. Adrian C Hayday: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom.
  10. Deena L Gibbons: Peter Gorer Department of Immunobiology, King's College London, London SE1 9RT, United Kingdom; deena.gibbons@kcl.ac.uk. ORCID
PMID: 28754679 DOI: 10.4049/jimmunol.1700551

Abstract

We recently demonstrated that the major effector function of neonatal CD4 T cells is to produce CXCL8, a prototypic cytokine of innate immune cells. In this article, we show that CXCL8 expression, prior to proliferation, is common in newly arising T cells (so-called "recent thymic emigrants") in adults, as well as in babies. This effector potential is acquired in the human thymus, prior to TCR signaling, but rather than describing end-stage differentiation, such cells, whether isolated from neonates or adults, can further differentiate into IFN-γ-producing CD4 T cells. Thus, the temporal transition of host defense from innate to adaptive immunity is unexpectedly mirrored at the cellular level by the capacity of human innate-like CXCL8-producing CD4 T cells to transition directly into Th1 cells.

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Grants

  1. 20265/Cancer Research UK
  2. 15692/Cancer Research UK
  3. 106292/Wellcome Trust
  4. A20730/Cancer Research UK
  5. /Wellcome Trust

MeSH Term

Adaptive Immunity
Adult
Animals
CD4-Positive T-Lymphocytes
Cell Differentiation
Cells, Cultured
Humans
Immunity, Innate
Infant, Newborn
Interferon-gamma
Interleukin-8
Mice
Mice, SCID
Neuroblastoma
Receptors, Antigen, T-Cell
Thymocytes
Wilms Tumor

Chemicals

Interleukin-8
Receptors, Antigen, T-Cell
Interferon-gamma
Journal Article Research Support, Non-U.S. Gov't

Links to CNCB-NGDC Resources

GEN: GEND000216 (Innate to adaptive: Human IFN-gamma producing CD4+ T cells can derive directly from CXCL8-producing recent thymic emigrants.)

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