Autophagy is an evolutionarily conserved cellular pathway that culminates in lysosomal degradation of selected substrates. Autophagy can serve dual roles in virus infection with either pro- or antiviral functions depending on the virus and the stage of the viral replication cycle. Recent studies have suggested a role for autophagy in Zika virus (ZIKV) replication by demonstrating the accumulation of autophagic vesicles following ZIKV infection in both in vitro and in vivo models. In human fetal neural stem cells, ZIKV inhibits Akt-mTOR signaling to induce autophagy, increase virus replication and impede neurogenesis. However, autophagy also has the potential to limit ZIKV replication, with separate studies demonstrating antiviral roles for autophagy at the maternal-placental-fetal interface, and more specifically, at the endoplasmic reticulum where virus replication is established in an infected cell. Interestingly, ZIKV (and related flaviviruses) has evolved specific mechanisms to overcome autophagy at the ER, thus demonstrating important roles for these autophagic pathways in virus replication and host response. This review summarizes the known roles of autophagy in ZIKV replication and how they might influence virus tissue tropism and disease.
Cells. 2013 Jan 25;2(1):83-104
[PMID:
24709646]
Cell Host Microbe. 2009 Apr 23;5(4):365-75
[PMID:
19380115]
Annu Rev Virol. 2015 Nov;2(1):289-310
[PMID:
26958917]
Annu Rev Virol. 2014 Nov;1(1):133-46
[PMID:
26958718]
Science. 2011 Jun 17;332(6036):1429-33
[PMID:
21617040]
Cell Host Microbe. 2016 May 11;19(5):705-12
[PMID:
27066743]
Nat Rev Mol Cell Biol. 2013 Dec;14(12):759-74
[PMID:
24201109]
Placenta. 2014 Feb;35 Suppl:S69-73
[PMID:
24280233]
J Cell Sci. 2013 Aug 1;126(Pt 15):3237-47
[PMID:
23908376]
J Biol Chem. 2007 Dec 28;282(52):37298-302
[PMID:
17986448]
Cell Host Microbe. 2013 Aug 14;14(2):136-47
[PMID:
23954153]
Autophagy. 2014 Aug;10(8):1359-68
[PMID:
24991840]
Sci Rep. 2017 Mar 10;7:44286
[PMID:
28281680]
Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):2024-2029
[PMID:
28167751]
J Biol Chem. 2007 Mar 23;282(12):8873-82
[PMID:
17276984]
Mol Cell Biol. 2015 Dec 07;36(4):585-95
[PMID:
26644405]
Autophagy. 2014 May;10(5):913-25
[PMID:
24589857]
Nat Immunol. 2003 May;4(5):416-23
[PMID:
12719731]
N Engl J Med. 2009 Jun 11;360(24):2536-43
[PMID:
19516034]
FEBS Lett. 2010 Apr 2;584(7):1302-12
[PMID:
20074568]
Science. 2016 Nov 25;354(6315):1036-1041
[PMID:
27885029]
Nature. 2015 Apr 23;520(7548):563-6
[PMID:
25686604]
Nat Struct Mol Biol. 2013 Jan;20(1):59-66
[PMID:
23202584]
Cell Host Microbe. 2013 Aug 14;14(2):117-8
[PMID:
23954149]
Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):12048-53
[PMID:
23818581]
Front Immunol. 2017 Apr 24;8:467
[PMID:
28484462]
Cell. 2011 Dec 9;147(6):1226-31
[PMID:
22153070]
Mol Cell. 2014 Jul 17;55(2):238-52
[PMID:
24954904]
J Infect Dis. 2016 Oct 15;214(suppl 3):S319-S325
[PMID:
27511895]
J Cell Biol. 2008 Aug 25;182(4):685-701
[PMID:
18725538]
Emerg Infect Dis. 2011 May;17(5):880-2
[PMID:
21529401]
N Engl J Med. 2016 Oct 20;375(16):1598-1601
[PMID:
27579558]
Trends Cell Biol. 2015 Jun;25(6):354-63
[PMID:
25759175]
Autophagy. 2017 Jun 3;13(6):1086-1087
[PMID:
28368693]
Cell Host Microbe. 2017 Feb 8;21(2):134-142
[PMID:
28182948]
J Biol Chem. 2006 Mar 31;281(13):8854-63
[PMID:
16436383]
Nature. 2013 Apr 18;496(7445):367-71
[PMID:
23542590]
Trends Cell Biol. 2016 Jan;26(1):6-16
[PMID:
26437584]
Autophagy. 2012 Apr;8(4):445-544
[PMID:
22966490]
J Virol. 2007 May;81(9):4881-5
[PMID:
17301152]
Biochim Biophys Acta. 2014 Jun;1837(6):857-79
[PMID:
24508215]
J Virol. 2015 Sep;89(17):8880-96
[PMID:
26085147]
J Virol. 2015 Aug;89(15):8026-41
[PMID:
26018155]
Cell Biol Toxicol. 2017 Apr;33(2):145-168
[PMID:
27957648]
Autophagy. 2017 Jun 3;13(6):1084-1085
[PMID:
28368721]
Virology. 2017 Jan 15;501:54-62
[PMID:
27863275]
Science. 2016 Apr 22;352(6284):467-70
[PMID:
27033547]
Autophagy. 2005 Apr;1(1):1-10
[PMID:
16874026]
Nature. 2013 Mar 21;495(7441):389-93
[PMID:
23455425]
Adv Virus Res. 2016;95:149-95
[PMID:
27112282]
Autophagy. 2017 Feb;13(2):322-332
[PMID:
28102736]
J Cell Biol. 2016 Aug 29;214(5):619-35
[PMID:
27573464]
Lancet. 2008 Feb 9;371(9611):500-9
[PMID:
18262042]
Annu Rev Cell Dev Biol. 2016 Oct 6;32:223-253
[PMID:
27501449]
Placenta. 2011 Aug;32(8):539-45
[PMID:
21665273]
Cell. 2015 Feb 12;160(4):619-630
[PMID:
25679758]
Microbes Infect. 2012 Feb;14(2):126-39
[PMID:
22051604]
Cell Stem Cell. 2016 Nov 3;19(5):663-671
[PMID:
27524440]
Cell Rep. 2017 Feb 28;18(9):2113-2123
[PMID:
28249158]
Cell Host Microbe. 2010 Nov 18;8(5):422-32
[PMID:
21075353]
Autophagy. 2017 Jul 3;13(7):1252-1253
[PMID:
28537477]
Cell Rep. 2017 Apr 18;19(3):558-568
[PMID:
28423319]
Cell Host Microbe. 2016 Jan 13;19(1):102-13
[PMID:
26764600]
J Exp Med. 2017 Aug 7;214(8):2303-2313
[PMID:
28694387]
Nature. 2015 Jun 18;522(7556):354-8
[PMID:
26040720]
Dev Cell. 2016 Jul 11;38(1):86-99
[PMID:
27404361]
EMBO J. 2017 Jun 14;36(12):1653-1668
[PMID:
28473450]
Cell Rep. 2016 Aug 30;16(9):2339-47
[PMID:
27545892]
Nat Rev Mol Cell Biol. 2001 Mar;2(3):211-6
[PMID:
11265251]
