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09 23, 2017;9 (10):

Canonical and Non-Canonical Autophagy in HIV-1 Replication Cycle.

Olivier Leymarie, Leslie Lepont, Clarisse Berlioz-Torrent
Author Information
  1. Olivier Leymarie: Inserm, U1016, Institut Cochin, 75014 Paris, France. olivier.leymarie@inserm.fr.
  2. Leslie Lepont: Inserm, U1016, Institut Cochin, 75014 Paris, France. leslie.lepont@inserm.fr.
  3. Clarisse Berlioz-Torrent: Inserm, U1016, Institut Cochin, 75014 Paris, France. clarisse.berlioz@inserm.fr.
PMID: 28946621 DOI: 10.3390/v9100270

Abstract

Autophagy is a lysosomal-dependent degradative process essential for maintaining cellular homeostasis, and is a key player in innate and adaptive immune responses to intracellular pathogens such as human immunodeficiency virus type 1 (HIV-1). In HIV-1 target cells, autophagy mechanisms can (i) selectively direct viral proteins and viruses for degradation; (ii) participate in the processing and presentation of viral-derived antigens through major histocompatibility complexes; and (iii) contribute to interferon production in response to HIV-1 infection. As a consequence, HIV-1 has evolved different strategies to finely regulate the autophagy pathway to favor its replication and dissemination. HIV-1 notably encodes accessory genes encoding Tat, Nef and Vpu proteins, which are able to perturb and hijack canonical and non-canonical autophagy mechanisms. This review outlines the current knowledge on the complex interplay between autophagy and HIV-1 replication cycle, providing an overview of the autophagy-mediated molecular processes deployed both by infected cells to combat the virus and by HIV-1 to evade antiviral response.

Keywords

Env HIV-1 LC3 LC3-associated phagocytosis Nef Tat Vpu autophagy

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MeSH Term

Adaptive Immunity
Antigens, Viral
Autophagy
Autophagy-Related Proteins
HIV Infections
HIV-1
Human Immunodeficiency Virus Proteins
Humans
Immunity, Innate
Lysosomes
Major Histocompatibility Complex
Viral Regulatory and Accessory Proteins
Virus Replication
nef Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus

Chemicals

Antigens, Viral
Autophagy-Related Proteins
Human Immunodeficiency Virus Proteins
Viral Regulatory and Accessory Proteins
nef Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
vpu protein, Human immunodeficiency virus 1
Journal Article Review Research Support, Non-U.S. Gov't

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