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Nutrients
Sep 27, 2017;9 (10):

Cynanchum wilfordii Ameliorates Testosterone-Induced Benign Prostatic Hyperplasia by Regulating 5α-Reductase and Androgen Receptor Activities in a Rat Model.

Gyuok Lee, Jawon Shin, Hakjoon Choi, Ara Jo, SangO Pan, Donghyuck Bae, Yongwook Lee, Chulyung Choi
Author Information
  1. Gyuok Lee: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. yellowlgo@naver.com.
  2. Jawon Shin: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. sjo8127@naver.com.
  3. Hakjoon Choi: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. ohchj12@naver.com.
  4. Ara Jo: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. joara9153@naver.com.
  5. SangO Pan: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. jacovan77@gmail.com.
  6. Donghyuck Bae: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. bdhyuch@naver.com.
  7. Yongwook Lee: Herbal Hormone Research Institute, Naturalendo Tech Co., Ltd., Gyeonggido, Seongnam 13486, Korea. ywlee@naturalendo.co.kr.
  8. Chulyung Choi: Jeonnam Institute of Natural Resources Research, Jangheung-gun, Jeollanamdo 59338, Korea. blockstar@hanmail.net.
PMID: 28953224 DOI: 10.3390/nu9101070

Abstract

Benign prostatic hyperplasia (BPH) is characterized by uncontrolled proliferation of the prostate gland. has been reported to improve sexual behavior in male rats. In this study, we investigated the protective effect of an aqueous extract of (CWW) against BPH development in a testosterone-induced BPH rat model. The rats were divided into the following six groups: sham/vehicle; BPH/vehicle; BPH/finasteride; and three CWW doses (50, 100, and 200 mg/kg). After a 4-week treatment with CWW, the rats were euthanized at scheduled times, and their prostates were weighed, followed by a histopathological examination. Prostate growth inhibition rates in rats administered CWW 50, 100, and 200 mg/kg were 54.5%, 51.8%, and 50.1%, respectively. The BPH/CWW group showed decreased serum testosterone and dihydrotestosterone (DHT) levels compared to the BPH/vehicle group. Furthermore, the BPH/CWW group showed reduced prostate testosterone and DHT levels compared to the BPH/vehicle group. Mechanistically, the reverse transcription-polymerase chain reaction revealed downregulated mRNA expression levels of the androgen receptor, 5α-reductase, and B-cell lymphoma-2 (Bcl-2) in the BPH/CWW200 group compared with those in the testosterone-induced groups. In conclusion, these findings show the effectiveness of CWW in slowing the progression of testosterone-induced BPH in rats.

Keywords

5α-reductase Cynanchum wilfordii androgen receptor benign prostatic hyperplasia finasteride

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MeSH Term

5-alpha Reductase Inhibitors
Androgen Receptor Antagonists
Animals
Cell Proliferation
Cholestenone 5 alpha-Reductase
Cynanchum
Disease Models, Animal
Dose-Response Relationship, Drug
Male
Organ Size
Plant Extracts
Plant Roots
Prostate
Prostate-Specific Antigen
Prostatic Hyperplasia
Proto-Oncogene Proteins c-bcl-2
Rats, Sprague-Dawley
Receptors, Androgen
Testosterone
Time Factors

Chemicals

5-alpha Reductase Inhibitors
Androgen Receptor Antagonists
Bcl2 protein, rat
Plant Extracts
Proto-Oncogene Proteins c-bcl-2
Receptors, Androgen
Testosterone
Cholestenone 5 alpha-Reductase
Prostate-Specific Antigen
Journal Article

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