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10 10, 2017;6

A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection.

Shanshan Zhao, Wei Hong, Jianguo Wu, Yu Wang, Shaoyi Ji, Shuyi Zhu, Chunhong Wei, Jinsong Zhang, Yi Li
Author Information
  1. Shanshan Zhao: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  2. Wei Hong: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  3. Jianguo Wu: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China. ORCID
  4. Yu Wang: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  5. Shaoyi Ji: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  6. Shuyi Zhu: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  7. Chunhong Wei: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China.
  8. Jinsong Zhang: State Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
  9. Yi Li: State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing, China. ORCID
PMID: 28994391 DOI: 10.7554/eLife.27529

Abstract

Ethylene plays critical roles in plant development and biotic stress response, but the mechanism of ethylene in host antiviral response remains unclear. Here, we report that (RDV) triggers ethylene production by stimulating the activity of S-adenosyl-L-methionine synthetase (SAMS), a key component of the ethylene synthesis pathway, resulting in elevated susceptibility to RDV. RDV-encoded Pns11 protein specifically interacted with OsSAMS1 to enhance its enzymatic activity, leading to higher ethylene levels in both RDV-infected and Pns11-overexpressing rice. Consistent with a counter-defense role for ethylene, Pns11-overexpressing rice, as well as those overexpressing , were substantially more susceptible to RDV infection, and a similar effect was observed in rice plants treated with an ethylene precursor. Conversely, knockout mutants, as well as an mutant defective in ethylene signaling, resisted RDV infection more robustly. Our findings uncover a novel mechanism which RDV manipulates ethylene biosynthesis in the host plants to achieve efficient infection.

Keywords

Oryza sativa RDV plant biology rice virus

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MeSH Term

Ethylenes
Gene Knockout Techniques
Host-Pathogen Interactions
Methionine Adenosyltransferase
Oryza
Plant Viruses
Viral Proteins
Virus Diseases

Chemicals

Ethylenes
Viral Proteins
ethylene
Methionine Adenosyltransferase
Journal Article Research Support, Non-U.S. Gov't

Links to CNCB-NGDC Resources

GEN: GEND000539 (A viral protein promotes host SAMS1 activity and ethylene production for the benefit of virus infection)

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