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Psychopharmacology
01, 2018;235 (1): 121-134.

Adolescent cannabinoid exposure effects on natural reward seeking and learning in rats.

H Schoch, M Y Huerta, C M Ruiz, M R Farrell, K M Jung, J J Huang, R R Campbell, D Piomelli, S V Mahler
Author Information
  1. H Schoch: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  2. M Y Huerta: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  3. C M Ruiz: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  4. M R Farrell: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  5. K M Jung: Department of Anatomy & Neurobiology, University of California, Irvine, CA, USA.
  6. J J Huang: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  7. R R Campbell: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA.
  8. D Piomelli: Department of Anatomy & Neurobiology, University of California, Irvine, CA, USA.
  9. S V Mahler: Department of Neurobiology & Behavior, University of California, 1203 McGaugh Hall, Irvine, CA, 92697, USA. mahlers@uci.edu.
PMID: 29022083 DOI: 10.1007/s00213-017-4749-8

Abstract

RATIONALE: Adolescence is characterized by endocannabinoid (ECB)-dependent refinement of neural circuits underlying emotion, learning, and motivation. As a result, adolescent cannabinoid receptor stimulation (ACRS) with phytocannabinoids or synthetic agonists like "Spice" cause robust and persistent changes in both behavior and circuit architecture in rodents, including in reward-related regions like medial prefrontal cortex and nucleus accumbens (NAc).
OBJECTIVES AND METHODS: Here, we examine persistent effects of ACRS with the cannabinoid receptor 1/2 specific agonist WIN55-212,2 (WIN; 1.2 mg/kg/day, postnatal day (PD) 30-43), on natural reward-seeking behaviors and ECB system function in adult male Long Evans rats (PD 60+).
RESULTS: WIN ACRS increased palatable food intake, and altered attribution of incentive salience to food cues in a sign-/goal-tracking paradigm. ACRS also blunted hunger-induced sucrose intake, and resulted in increased anandamide and oleoylethanolamide levels in NAc after acute food restriction not seen in controls. ACRS did not affect food neophobia or locomotor response to a novel environment, but did increase preference for exploring a novel environment.
CONCLUSIONS: These results demonstrate that ACRS causes long-term increases in natural reward-seeking behaviors and ECB system function that persist into adulthood, potentially increasing liability to excessive natural reward seeking later in life.

Keywords

Autoshaping Endocannabinoid Novelty Nucleus accumbens Palatable food Reward

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Grants

  1. R00 DA035251/NIDA NIH HHS
  2. R01 DA012413/NIDA NIH HHS
  3. Ayala School Office of Research Seed Grant/University of California, Irvine

MeSH Term

Animals
Arachidonic Acids
Behavior, Animal
Benzoxazines
Cannabinoids
Eating
Endocannabinoids
Male
Morpholines
Motivation
Naphthalenes
Nucleus Accumbens
Oleic Acids
Polyunsaturated Alkamides
Rats
Rats, Long-Evans
Rats, Sprague-Dawley
Reward

Chemicals

Arachidonic Acids
Benzoxazines
Cannabinoids
Endocannabinoids
Morpholines
Naphthalenes
Oleic Acids
Polyunsaturated Alkamides
oleoylethanolamide
(3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone
anandamide
Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

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