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Frontiers in chemistry
2018;6 19.

Total Chemical Synthesis of Modified Histones.

Yun-Kun Qi, Hua-Song Ai, Yi-Ming Li, Baihui Yan
Author Information
  1. Yun-Kun Qi: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
  2. Hua-Song Ai: Department of Chemistry, Tsinghua University, Beijing, China.
  3. Yi-Ming Li: Department of Pharmacy, School of Biological and Medical Engineering, Hefei University of Technology, Hefei, China.
  4. Baihui Yan: Department of Anesthesiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
PMID: 29473034 DOI: 10.3389/fchem.2018.00019

Abstract

In the post-genome era, epigenetics has received increasing attentions in recent years. The post-translational modifications (PTMs) of four core histones play central roles in epigenetic regulation of eukaryotic genome by either directly altering the biophysical properties of nucleosomes or by recruiting other effector proteins. In order to study the biological functions and structural mechanisms of these histone PTMs, an obligatory step is to prepare a sufficient amount of homogeneously modified histones. This task cannot be fully accomplished either by recombinant technology or enzymatic modification. In this context, synthetic chemists have developed novel protein synthetic tools and state-of-the-art chemical ligation strategies for the preparation of homologous modified histones. In this review, we summarize the recent advances in the preparation of modified histones, focusing on the total chemical synthesis strategies. The importance and potential of synthetic chemistry for the study of histone code will be also discussed.

Keywords

histones native chemical ligation post-translational modifications protein chemical synthesis total chemical synthesis

References

Science. 2013 Dec 13;342(6164):1357-1360 [PMID: 24337294]
Nat Commun. 2017 Mar 22;8:14846 [PMID: 28327644]
Chem Sci. 2017 Oct 1;8(10):6881-6887 [PMID: 29147513]
Angew Chem Int Ed Engl. 2015 May 4;54(19):5713-7 [PMID: 25772600]
Org Biomol Chem. 2014 Aug 7;12(29):5435-41 [PMID: 24934931]
Nat Protoc. 2017 Nov;12(11):2293-2322 [PMID: 28981125]
Methods. 2014 Dec;70(2-3):134-8 [PMID: 25063569]
Science. 2016 Feb 12;351(6274):725-8 [PMID: 26912860]
Science. 2001 Aug 10;293(5532):1074-80 [PMID: 11498575]
Mol Cell Biol. 2005 Feb;25(3):1173-82 [PMID: 15657442]
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12033-8 [PMID: 14530408]
Chem Sci. 2016 Apr 21;7(4):2657-2665 [PMID: 28660038]
J Mol Biol. 2011 Apr 29;408(2):187-204 [PMID: 21310161]
Curr Opin Struct Biol. 2017 Feb;42:162-168 [PMID: 28284913]
Cell. 2008 Nov 14;135(4):604-7 [PMID: 19013272]
Nature. 2013 Jul 4;499(7456):50-4 [PMID: 23760478]
Annu Rev Biochem. 2013;82:81-118 [PMID: 23642229]
Chem Commun (Camb). 2017 Apr 6;53(29):4148-4151 [PMID: 28352864]
Chem Rev. 2015 Mar 25;115(6):2376-418 [PMID: 25688442]
Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6705-10 [PMID: 9618476]
Acc Chem Res. 2017 May 16;50(5):1143-1153 [PMID: 28374993]
Chem Sci. 2017 May 1;8(5):4027-4034 [PMID: 28580118]
Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14607-14611 [PMID: 28971554]
Angew Chem Int Ed Engl. 2011 Aug 8;50(33):7645-9 [PMID: 21648030]
Angew Chem Int Ed Engl. 2013 Jul 29;52(31):8059-63 [PMID: 23794525]
Nat Rev Mol Cell Biol. 2012 Feb 15;13(3):168-82 [PMID: 22334143]
ACS Chem Biol. 2009 Nov 20;4(11):958-68 [PMID: 19799466]
Chem Rev. 2014 May 14;114(9):4764-806 [PMID: 24655057]
Cell. 2013 Jul 18;154(2):297-310 [PMID: 23870121]
Nature. 2016 Aug 4;536(7614):100-3 [PMID: 27462807]
Cell. 2009 May 1;137(3):459-71 [PMID: 19410543]
Nat Methods. 2014 Aug;11(8):834-40 [PMID: 24997861]
Chem Commun (Camb). 2011 Feb 14;47(6):1746-8 [PMID: 21116520]
Angew Chem Int Ed Engl. 2007;46(16):2814-8 [PMID: 17366504]
Cell. 2012 Sep 14;150(6):1182-95 [PMID: 22980979]
Angew Chem Int Ed Engl. 2007;46(48):9248-52 [PMID: 18046687]
Acc Chem Res. 2013 Nov 19;46(11):2475-84 [PMID: 23701458]
Mol Cell. 2011 Jul 8;43(1):132-44 [PMID: 21726816]
Bioorg Med Chem. 2017 Sep 15;25(18):4966-4970 [PMID: 28434780]
J Am Chem Soc. 2012 Dec 5;134(48):19548-51 [PMID: 23163596]
Cell. 2007 Mar 9;128(5):1003-12 [PMID: 17350582]
J Biol Chem. 2015 Sep 11;290(37):22612-21 [PMID: 26175159]
Genes Dev. 2016 Apr 15;30(8):946-59 [PMID: 27083998]
Angew Chem Int Ed Engl. 2015 Feb 9;54(7):2194-8 [PMID: 25475965]
Nature. 2014 Dec 11;516(7530):267-71 [PMID: 25252977]
J Am Chem Soc. 2016 Jun 15;138(23):7429-35 [PMID: 27268299]
Angew Chem Int Ed Engl. 2016 Apr 11;55(16):4972-6 [PMID: 26960207]
Nature. 2008 Jun 5;453(7196):812-6 [PMID: 18449190]
Nat Chem. 2016 Jul;8(7):698-704 [PMID: 27325097]
Annu Rev Biochem. 2015;84:265-90 [PMID: 25784050]
Nat Commun. 2014;5:3291 [PMID: 24518117]
Nature. 2000 Jan 6;403(6765):41-5 [PMID: 10638745]
Science. 1994 Nov 4;266(5186):776-9 [PMID: 7973629]
Nat Protoc. 2013 Dec;8(12):2483-95 [PMID: 24232250]
Nat Rev Genet. 2014 Apr;15(4):259-71 [PMID: 24614311]
Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10365-70 [PMID: 26240340]
Angew Chem Int Ed Engl. 2011 Oct 4;50(41):9611-4 [PMID: 21922615]
Chem Rev. 2015 Mar 25;115(6):2296-349 [PMID: 25330018]
Chem Sci. 2016 Mar 1;7(3):1891-1895 [PMID: 29899912]
Org Biomol Chem. 2016 Mar 7;14(9):2603-7 [PMID: 26821702]
Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4858-62 [PMID: 23554020]
Chem Commun (Camb). 2016 Apr 11;52(28):4999-5002 [PMID: 26981611]
Nature. 1997 Sep 18;389(6648):251-60 [PMID: 9305837]
Biochemistry. 2017 Sep 12;56(36):4767-4772 [PMID: 28813589]
Chem Commun (Camb). 2015 Oct 7;51(78):14632-5 [PMID: 26289550]
J Am Chem Soc. 2011 Jul 27;133(29):11080-3 [PMID: 21714552]
Angew Chem Int Ed Engl. 2012 Oct 8;51(41):10347-50 [PMID: 22968928]
Nature. 2002 Sep 26;419(6905):407-11 [PMID: 12353038]
Org Biomol Chem. 2016 Jan 21;14(3):835-9 [PMID: 26615908]
Nat Rev Cancer. 2010 Jul;10(7):457-69 [PMID: 20574448]
Chem Commun (Camb). 2014 Oct 25;50(83):12534-7 [PMID: 25196573]
Chem Soc Rev. 2009 Feb;38(2):338-51 [PMID: 19169452]
Nature. 2010 May 13;465(7295):243-7 [PMID: 20436459]
Chem Sci. 2016 Mar 1;7(3):2005-2010 [PMID: 29899924]
Angew Chem Int Ed Engl. 2015 Oct 12;54(42):12374-8 [PMID: 26079184]
Nat Chem Biol. 2010 Apr;6(4):267-9 [PMID: 20208522]
Nat Chem. 2016 Apr 22;8(5):407-18 [PMID: 27102674]
Chembiochem. 2017 Jan 17;18(2):176-180 [PMID: 27976477]
Chem Commun (Camb). 2017 Feb 9;53(13):2114-2117 [PMID: 28133659]
J Pept Sci. 2016 May;22(5):252-9 [PMID: 26778211]
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