Visible-Light-Promoted Oxidative Amidation of Bromoalkynes with Anilines: An Approach to α-Ketoamides.

Advanced Search

Ke Ni, Ling-Guo Meng, Kuai Wang, Lei Wang

Author Information

Ke Ni: Department of Chemistry , Huaibei Normal University , Huaibei , Anhui 235000 , P. R. China.
Ling-Guo Meng: Department of Chemistry , Huaibei Normal University , Huaibei , Anhui 235000 , P. R. China.
Kuai Wang: Department of Chemistry , Huaibei Normal University , Huaibei , Anhui 235000 , P. R. China.
Lei Wang: Department of Chemistry , Huaibei Normal University , Huaibei , Anhui 235000 , P. R. China. ORCID

PMID: 29600860 DOI: 10.1021/acs.orglett.8b00586

A convenient and practical synthetic route to α-ketoamides from bromoalkynes and anilines through phototriggered organic transformations via a C-N cross-coupling and an oxidation of C≡C was developed. The reaction could be furnished without an external photocatalyst at ambient conditions, and a wide range of α-ketoamides were obtained in good yields.

Journal Article Research Support, Non-U.S. Gov't

OpenLB
Open Library of Bioscience