Improving feeding powder distribution to the compaction zone in the roller compaction.

Mingzhe Yu, Chalak Omar, Alexander Schmidt, James D Litster, Agba D Salman
Author Information
  1. Mingzhe Yu: Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom. Electronic address: myu14@sheffield.ac.uk.
  2. Chalak Omar: Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom.
  3. Alexander Schmidt: Alexanderwerk AG, Remscheid, North Rhine-Westphalia, Germany.
  4. James D Litster: Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom.
  5. Agba D Salman: Department of Chemical and Biological Engineering, University of Sheffield, Newcastle Street, Sheffield S1 3JD, United Kingdom. Electronic address: a.d.salman@sheffield.ac.uk.

Abstract

In the roller compaction process, powder flow properties have a significant influence on the uniformity of the ribbon properties. The objective of this work was to improve the powder flow in the feeding zone by developing novel feeding guiders which are located in the feeding zone close to the rollers in the roller compactor (side sealing system). Three novel feeding guiders were designed by 3D printing and used in the roller compactor, aiming to control the amount of powder passing across the roller width. The new feeding guiders were used to guide more powder to the sides between the rollers and less powder to the centre comparing to the original feeding elements. Temperature profile and porosity across the ribbon width indicated the uniformity of the ribbon properties. Using the novel feeding guiders resulted in producing ribbons with uniform temperature profile and porosity distribution across the ribbon width. The design of the feeding guiders contributed to improving the tensile strength of the ribbons produced from the compaction stage as well as reducing the fines produced from the crushing stage.

Keywords

MeSH Term

Drug Compounding
Particle Size
Porosity
Powders
Pressure
Printing, Three-Dimensional
Temperature
Tensile Strength

Chemicals

Powders

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