OpenLB Open Library of Bioscience

EWAS Data Hub: a resource of DNA methylation array data and metadata.

Zhuang Xiong, Mengwei Li, Fei Yang, Yingke Ma, Jian Sang, Rujiao Li, Zhaohua Li, Zhang Zhang, Yiming Bao
Author Information
  1. Zhuang Xiong: National Genomics Data Center, Beijing 100101, China.
  2. Mengwei Li: National Genomics Data Center, Beijing 100101, China.
  3. Fei Yang: National Genomics Data Center, Beijing 100101, China.
  4. Yingke Ma: National Genomics Data Center, Beijing 100101, China.
  5. Jian Sang: National Genomics Data Center, Beijing 100101, China.
  6. Rujiao Li: National Genomics Data Center, Beijing 100101, China.
  7. Zhaohua Li: National Genomics Data Center, Beijing 100101, China.
  8. Zhang Zhang: National Genomics Data Center, Beijing 100101, China.
  9. Yiming Bao: National Genomics Data Center, Beijing 100101, China.

Abstract

Epigenome-Wide Association Study (EWAS) has become an effective strategy to explore epigenetic basis of complex traits. Over the past decade, a large amount of epigenetic data, especially those sourced from DNA methylation array, has been accumulated as the result of numerous EWAS projects. We present EWAS Data Hub (https://bigd.big.ac.cn/ewas/datahub), a resource for collecting and normalizing DNA methylation array data as well as archiving associated metadata. The current release of EWAS Data Hub integrates a comprehensive collection of DNA methylation array data from 75 344 samples and employs an effective normalization method to remove batch effects among different datasets. Accordingly, taking advantages of both massive high-quality DNA methylation data and standardized metadata, EWAS Data Hub provides reference DNA methylation profiles under different contexts, involving 81 tissues/cell types (that contain 25 brain parts and 25 blood cell types), six ancestry categories, and 67 diseases (including 39 cancers). In summary, EWAS Data Hub bears great promise to aid the retrieval and discovery of methylation-based biomarkers for phenotype characterization, clinical treatment and health care.

MeSH Term

Biomarkers
DNA Methylation
Databases, Genetic
Epigenesis, Genetic
Epigenome
Genome-Wide Association Study
Humans
Metadata

Chemicals

Biomarkers

Links to CNCB-NGDC Resources

Database Commons: DBC006828 (EWAS Data Hub)

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