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International journal of nanomedicine
2020;15 347-361.

Hypoxia-Targeting Multifunctional Nanoparticles for Sensitized Chemotherapy and Phototherapy in Head and Neck Squamous Cell Carcinoma.

Chuanhui Song, Chuanchao Tang, Wenguang Xu, Jianchuan Ran, Zheng Wei, Yufeng Wang, Huihui Zou, Wei Cheng, Yu Cai, Wei Han
Author Information
  1. Chuanhui Song: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  2. Chuanchao Tang: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  3. Wenguang Xu: Department of Oral and Maxillofacial Surgery, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China. ORCID
  4. Jianchuan Ran: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  5. Zheng Wei: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  6. Yufeng Wang: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  7. Huihui Zou: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  8. Wei Cheng: Department of Oral Implantology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
  9. Yu Cai: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China. ORCID
  10. Wei Han: Central Laboratory of Stomatology, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing 210008, People's Republic of China.
PMID: 32021184 DOI: 10.2147/IJN.S233294

Abstract

PURPOSE: Chemotherapy in head and neck squamous cell carcinoma (HNSCC) has many systemic side effects, as well as hypoxia-induced chemoresistance. To reduce side effects and enhance chemosensitivity are urgently needed.
METHODS: We synthesized a drug delivery system (named CECMa NPs) based on cisplatin (CDDP) and metformin (chemotherapeutic sensitizer), of which chlorin e6 (Ce6) and polyethylene glycol diamine (PEG) were synthesized as the shell, an anti-LDLR antibody (which can target to hypoxic tumor cells) was modified on the surface to achieve tumor targeting.
RESULTS: The NPs possessed a great synergistic effect of chemotherapy and phototherapy. After laser stimulation, both CDDP and metformin can be released in situ to achieve anti-tumor effects. Meanwhile, PDT and PTT triggered by a laser have anticancer effects. Furthermore, compared with free cisplatin, CECMa exhibits less systemic toxicity with laser irradiation in the xenograft mouse tumor model.
CONCLUSION: CECMa effectively destroyed the tumors via hypoxia targeting multimodal therapy both in vitro and in vivo, thereby providing a novel strategy for targeting head and neck squamous cell carcinoma.

Keywords

chlorin e6 cisplatin head and neck squamous cell carcinoma metformin nano-delivery

References

J Biomed Mater Res B Appl Biomater. 2019 Nov;107(8):2658-2663 [PMID: 30864237]
Int J Nanomedicine. 2018 Jul 04;13:3921-3935 [PMID: 30013345]
Drug Resist Updat. 2016 Jan;24:34-54 [PMID: 26830314]
Cancer Med. 2018 May 15;:null [PMID: 29761938]
Nano Lett. 2009 Oct;9(10):3651-7 [PMID: 19736912]
Oral Oncol. 2017 Aug;71:150-155 [PMID: 28688683]
Nat Commun. 2019 Mar 22;10(1):1336 [PMID: 30902997]
J Am Chem Soc. 2014 Oct 22;136(42):15010-5 [PMID: 25290917]
Oncotarget. 2016 Jun 21;7(25):37773-37789 [PMID: 27191981]
Oncogene. 2018 Feb 15;37(7):873-883 [PMID: 29059160]
ACS Nano. 2019 Feb 26;13(2):1253-1271 [PMID: 30633492]
Oral Oncol. 2012 Mar;48(3):266-71 [PMID: 22079100]
Head Neck. 2013 Sep;35(9):1362-70 [PMID: 22941934]
Theranostics. 2018 Oct 22;8(19):5259-5275 [PMID: 30555545]
Mol Cancer. 2017 Jun 21;16(1):106 [PMID: 28633632]
J Photochem Photobiol B. 2019 Mar;192:19-25 [PMID: 30665146]
ACS Chem Biol. 2013 Jan 18;8(1):127-32 [PMID: 23092119]
Cancer Lett. 2016 Sep 28;380(1):203-4 [PMID: 27060765]
J Am Chem Soc. 2015 Feb 11;137(5):1947-55 [PMID: 25597855]
Pharmacol Res. 2019 May;143:178-185 [PMID: 30611856]
Biomater Sci. 2019 Jun 25;7(7):2749-2758 [PMID: 30997445]
ChemMedChem. 2019 Jul 17;14(14):1315-1320 [PMID: 31207080]
Acta Oncol. 2013 Jun;52(5):1002-9 [PMID: 22950385]
J Am Chem Soc. 2013 Mar 27;135(12):4799-804 [PMID: 23495667]
Mol Cancer Ther. 2010 May;9(5):1092-9 [PMID: 20442309]
CA Cancer J Clin. 2016 Jan-Feb;66(1):7-30 [PMID: 26742998]
Clin Transl Oncol. 2017 Jun;19(6):769-776 [PMID: 28120324]
Lasers Med Sci. 2014 Mar;29(2):847-53 [PMID: 23917412]
Curr Med Chem. 2017;24(39):4399-4416 [PMID: 28799495]
Nat Rev Cancer. 2011 Jun;11(6):393-410 [PMID: 21606941]

MeSH Term

Animals
Antineoplastic Combined Chemotherapy Protocols
Cell Line, Tumor
Chlorophyllides
Cisplatin
Combined Modality Therapy
Drug Delivery Systems
Head and Neck Neoplasms
Humans
Male
Metformin
Mice, Inbred BALB C
Multifunctional Nanoparticles
Photochemotherapy
Phototherapy
Polyethylene Glycols
Porphyrins
Squamous Cell Carcinoma of Head and Neck
Tumor Hypoxia
Xenograft Model Antitumor Assays

Chemicals

Chlorophyllides
Porphyrins
Polyethylene Glycols
phytochlorin
Metformin
Cisplatin
Journal Article

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