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Cold Spring Harbor perspectives in medicine
08 02, 2021;11 (8):

Next-Generation Influenza Vaccines.

Masaru Kanekiyo, Barney S Graham
Author Information
  1. Masaru Kanekiyo: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
  2. Barney S Graham: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
PMID: 32229612 DOI: 10.1101/cshperspect.a038448

Abstract

Most currently used conventional influenza vaccines are based on 1940s technology. Advances in vaccine immunogen design and delivery emerging over the last decade promise new options for improving influenza vaccines. In addition, new technologies for immune profiling provide better-defined immune correlates of protection and precise surrogate biomarkers for vaccine evaluations. Major technological advances include single-cell analysis, high-throughput antibody discovery, next-generation sequencing of antibody gene transcripts, antibody ontogeny, structure-guided immunogen design, nanoparticle display, delivery and formulation options, and better adjuvants. In this review, we provide our prospective outlook for improved influenza vaccines in the foreseeable future.

References

Cold Spring Harb Perspect Med. 2020 Sep 1;10(9): [PMID: 31871230]
Science. 1993 Nov 26;262(5138):1448-51 [PMID: 8248784]
Cold Spring Harb Perspect Med. 2020 Aug 3;10(8): [PMID: 31871236]
N Engl J Med. 2014 Aug 14;371(7):635-45 [PMID: 25119609]
Sci Transl Med. 2017 Oct 18;9(412): [PMID: 29046433]
J Infect Dis. 2019 Sep 13;220(8):1265-1275 [PMID: 30561689]
Vaccine. 2017 Jan 23;35(4):513-520 [PMID: 28024956]
J Exp Med. 1931 Jul 31;54(3):373-85 [PMID: 19869924]
Expert Rev Vaccines. 2018 May;17(5):435-443 [PMID: 29715054]
Vaccine. 2018 Jun 27;36(28):4095-4101 [PMID: 29861178]
Expert Rev Vaccines. 2017 Feb;16(2):123-136 [PMID: 27653543]
Virology. 1983 Jun;127(2):361-73 [PMID: 6868370]
EMBO J. 2014 Apr 16;33(8):823-41 [PMID: 24668228]
Curr Opin Biotechnol. 2007 Dec;18(6):529-36 [PMID: 18083548]
Lancet Infect Dis. 2016 Aug;16(8):942-51 [PMID: 27061888]
Curr Opin Virol. 2011 Sep;1(3):177-83 [PMID: 22034587]
Semin Immunol. 2018 Oct;39:14-21 [PMID: 29801750]
J Virol. 2014 Jul;88(13):7130-44 [PMID: 24719430]
Immunol Cell Biol. 2017 Sep;95(8):651-655 [PMID: 28405016]
Nat Commun. 2017 Jan 19;8:14234 [PMID: 28102191]
Nature. 1981 Jan 29;289(5796):366-73 [PMID: 7464906]
J Gen Virol. 2017 Jun;98(6):1274-1281 [PMID: 28612701]
J Infect Dis. 2018 Jul 2;218(3):378-387 [PMID: 29617814]
Science. 2019 Oct 25;366(6464):499-504 [PMID: 31649200]
Influenza Other Respir Viruses. 2012 Jul;6(4):245-56 [PMID: 22085243]
PLoS One. 2008;3(12):e3942 [PMID: 19079604]
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14216-21 [PMID: 21825125]
Curr Top Microbiol Immunol. 1985;114:177-255 [PMID: 2581739]
J Infect Dis. 2017 Jun 15;215(12):1782-1788 [PMID: 28398521]
J Exp Med. 1984 Aug 1;160(2):552-63 [PMID: 6206181]
J Infect Dis. 2019 Apr 8;219(Suppl_1):S75-S80 [PMID: 30715357]
Front Immunol. 2017 Dec 13;8:1760 [PMID: 29326687]
Clin Infect Dis. 2012 Oct;55(7):951-9 [PMID: 22843783]
mBio. 2019 Feb 26;10(1): [PMID: 30808695]
J Infect Dis. 2019 Apr 8;219(Suppl_1):S88-S96 [PMID: 30715361]
Virology. 1986 Feb;149(1):36-43 [PMID: 3511607]
Science. 2012 Sep 14;337(6100):1343-8 [PMID: 22878502]
Cell. 2016 Jul 28;166(3):596-608 [PMID: 27453466]
Nature. 2012 Sep 27;489(7417):526-32 [PMID: 22982990]
Virology. 1984 Sep;137(2):314-23 [PMID: 6485252]
Sci Immunol. 2017 Jul 14;2(13): [PMID: 28783708]
J Biomed Sci. 2019 Oct 19;26(1):76 [PMID: 31629405]
Vaccine. 2003 Oct 1;21(27-30):4234-7 [PMID: 14505903]
Curr Opin Virol. 2011 Oct;1(4):254-62 [PMID: 22125588]
J Infect Dis. 2019 Apr 8;219(Suppl_1):S68-S74 [PMID: 30715367]
Science. 2009 Apr 10;324(5924):246-51 [PMID: 19251591]
Lancet Infect Dis. 2020 Jan;20(1):80-91 [PMID: 31630990]
J Autoimmun. 2014 May;50:1-11 [PMID: 24559657]
Cell Rep. 2017 Sep 19;20(12):2935-2943 [PMID: 28930686]
Cell. 2015 May 21;161(5):1026-1034 [PMID: 25959776]
Nat Rev Microbiol. 2019 Jan;17(2):67-81 [PMID: 30487536]
Curr Opin Immunol. 2018 Aug;53:187-195 [PMID: 29890370]
BMJ. 2011 Feb 03;342:c7297 [PMID: 21292718]
Vaccine. 2017 May 15;35(21):2775-2780 [PMID: 28431815]
Nature. 1983 May 5-11;303(5912):41-4 [PMID: 6188957]
Trends Microbiol. 2008 Apr;16(4):149-57 [PMID: 18375125]
Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19123-7 [PMID: 17146053]
Nat Med. 2016 Dec;22(12):1465-1469 [PMID: 27820604]
Proteins. 1989;6(4):341-56 [PMID: 2482974]
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):125-30 [PMID: 24344259]
J Virol. 2013 Jun;87(12):6542-50 [PMID: 23576508]
Science. 1942 Nov 27;96(2500):499-500 [PMID: 17742872]
Nature. 1981 Jan 29;289(5796):373-8 [PMID: 6162101]
Virology. 1969 May;38(1):105-19 [PMID: 5784043]
J Virol. 1968 Aug;2(8):778-86 [PMID: 5701819]
Science. 2011 Aug 12;333(6044):843-50 [PMID: 21737702]
Cell. 2019 Mar 7;176(6):1420-1431.e17 [PMID: 30849373]
Nat Struct Mol Biol. 2009 Mar;16(3):265-73 [PMID: 19234466]
AAPS J. 2011 Sep;13(3):427-37 [PMID: 21656080]
Nat Med. 2019 Jun;25(6):962-967 [PMID: 31160818]
Vaccine. 2008 Sep 12;26 Suppl 4:D49-53 [PMID: 19230160]
Nat Med. 2016 Dec;22(12):1456-1464 [PMID: 27820605]
Curr Top Microbiol Immunol. 2014;385:93-116 [PMID: 25007844]
mBio. 2018 Apr 3;9(2): [PMID: 29615508]
N Engl J Med. 1972 Jun 22;286(25):1329-32 [PMID: 5027388]
Science. 2014 Nov 21;346(6212):996-1000 [PMID: 25414313]
Viruses. 2017 Dec 07;9(12): [PMID: 29215570]
Value Health. 2012 Jan;15(1):158-66 [PMID: 22264984]
Cold Spring Harb Perspect Med. 2020 Nov 2;10(11): [PMID: 31871242]
Expert Rev Vaccines. 2017 Jul;16(7):1-14 [PMID: 28562111]
PLoS One. 2011;6(8):e23085 [PMID: 21857999]
Cell. 2016 Jul 28;166(3):609-623 [PMID: 27453470]
Proc Natl Acad Sci U S A. 1986 Dec;83(24):9794-8 [PMID: 2879286]
Curr Opin Immunol. 2018 Aug;53:96-101 [PMID: 29730560]
J Immunol. 2011 Jan 15;186(2):1022-31 [PMID: 21169548]
Cell Host Microbe. 2010 Jun 25;7(6):440-51 [PMID: 20542248]
Viruses. 2019 Apr 16;11(4): [PMID: 31014029]
Nat Med. 2010 Dec;16(12):1389-91 [PMID: 21135852]
Nat Med. 2013 Oct;19(10):1305-12 [PMID: 24056771]
Nat Commun. 2015 May 13;6:6833 [PMID: 25967273]
Vaccine. 2014 Sep 3;32(39):5027-34 [PMID: 25045825]
Science. 2011 Aug 12;333(6044):850-6 [PMID: 21798894]
Cold Spring Harb Perspect Biol. 2018 Jul 2;10(7): [PMID: 28663208]
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13133-8 [PMID: 25157133]
Nature. 1981 Apr 23;290(5808):713-7 [PMID: 6163993]
N Engl J Med. 1983 Jul 7;309(1):13-7 [PMID: 6602294]
Science. 1931 Oct 9;74(1919):371-2 [PMID: 17810781]
Immunity. 2016 Sep 20;45(3):471-482 [PMID: 27653600]
J Clin Invest. 2019 Feb 1;129(2):850-862 [PMID: 30521496]
Nat Immunol. 2019 Mar;20(3):362-372 [PMID: 30742080]
Nature. 1983 May 5-11;303(5912):35-40 [PMID: 6843658]
Nat Med. 2015 Sep;21(9):1065-70 [PMID: 26301691]
Immunity. 2017 Aug 15;47(2):224-233 [PMID: 28813656]
Cell. 2018 Apr 5;173(2):417-429.e10 [PMID: 29625056]
Sci Transl Med. 2019 Jul 24;11(502): [PMID: 31341062]
Cell Host Microbe. 2013 Jul 17;14(1):93-103 [PMID: 23870317]
Proc Natl Acad Sci U S A. 2017 Nov 21;114(47):12578-12583 [PMID: 29109276]
Proc Natl Acad Sci U S A. 2018 Jan 2;115(1):168-173 [PMID: 29255041]
Lancet. 1973 Mar 24;1(7804):623-5 [PMID: 4121842]
J Virol. 1993 May;67(5):2552-8 [PMID: 7682624]
Clin Infect Dis. 2014 Feb;58(3):319-27 [PMID: 24235265]
Viruses. 2014 Jun 23;6(6):2465-94 [PMID: 24960271]
ACS Infect Dis. 2018 May 11;4(5):788-796 [PMID: 29451984]
J Infect Dis. 2015 May 15;211(10):1529-40 [PMID: 25406334]
Clin Infect Dis. 2014 Nov 15;59(10):1375-85 [PMID: 25270645]
Clin Infect Dis. 2020 Dec 15;71(12):3096-3102 [PMID: 31840159]
Cold Spring Harb Perspect Med. 2021 Mar 1;11(3): [PMID: 31871226]
Nat Commun. 2014 Apr 10;5:3614 [PMID: 24717798]
Sci Transl Med. 2015 Dec 2;7(316):316ra192 [PMID: 26631631]
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):445-50 [PMID: 24335589]
Science. 2015 Sep 18;349(6254):1301-6 [PMID: 26303961]
Annu Rev Biochem. 2000;69:531-69 [PMID: 10966468]
Vaccine. 2011 Sep 2;29(38):6558-63 [PMID: 21767593]
Curr Opin Virol. 2017 Jun;24:60-69 [PMID: 28527859]
Nat Med. 1999 Oct;5(10):1157-63 [PMID: 10502819]
Front Immunol. 2019 Mar 18;10:440 [PMID: 30949165]
Cell. 2019 May 16;177(5):1136-1152.e18 [PMID: 31100268]
Cell. 2019 May 16;177(5):1124-1135.e16 [PMID: 31100267]
Science. 2016 Nov 11;354(6313):722-726 [PMID: 27846599]
EMBO J. 1992 Jan;11(1):49-56 [PMID: 1740114]
Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12658-63 [PMID: 20615945]
Trends Microbiol. 2020 Jan;28(1):57-67 [PMID: 31629602]
Nature. 1982 Dec 16;300(5893):655-7 [PMID: 6183597]
Nature. 2013 Jul 4;499(7456):102-6 [PMID: 23698367]
J Mol Biol. 2017 Aug 18;429(17):2694-2709 [PMID: 28648617]
Bull World Health Organ. 1969;41(3):647-50 [PMID: 5309490]
Cell. 1986 Mar 28;44(6):959-68 [PMID: 2420472]
BMC Infect Dis. 2019 May 22;19(1):453 [PMID: 31117986]
Front Microbiol. 2019 Jan 29;10:39 [PMID: 30761095]
JAMA. 2018 Apr 10;319(14):1431-1432 [PMID: 29566112]

MeSH Term

Adjuvants, Immunologic
Humans
Influenza Vaccines
Influenza, Human
Prospective Studies

Chemicals

Adjuvants, Immunologic
Influenza Vaccines
Journal Article Research Support, N.I.H., Intramural Review

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