Horizontal gene transfer of from fungus underlies head blight resistance in wheat.
Hongwei Wang, Silong Sun, Wenyang Ge, Lanfei Zhao, Bingqian Hou, Kai Wang, Zhongfan Lyu, Liyang Chen, Shoushen Xu, Jun Guo, Min Li, Peisen Su, Xuefeng Li, Guiping Wang, Cunyao Bo, Xiaojian Fang, Wenwen Zhuang, Xinxin Cheng, Jianwen Wu, Luhao Dong, Wuying Chen, Wen Li, Guilian Xiao, Jinxiao Zhao, Yongchao Hao, Ying Xu, Yu Gao, Wenjing Liu, Yanhe Liu, Huayan Yin, Jiazhu Li, Xiang Li, Yan Zhao, Xiaoqian Wang, Fei Ni, Xin Ma, Anfei Li, Steven S Xu, Guihua Bai, Eviatar Nevo, Caixia Gao, Herbert Ohm, Lingrang Kong
Author Information
Hongwei Wang: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. lkong@sdau.edu.cn wanghongwei@sdau.edu.cn. ORCID
Silong Sun: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. ORCID
Wenyang Ge: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Lanfei Zhao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. ORCID
Bingqian Hou: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Kai Wang: Novogene Bioinformatics Institute, Beijing 100083, PR China. ORCID
Zhongfan Lyu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Liyang Chen: Novogene Bioinformatics Institute, Beijing 100083, PR China. ORCID
Shoushen Xu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Jun Guo: Crop Research Institute, Shandong Academy of Agricultural Sciences, Jinan, Shandong 250100, PR China.
Min Li: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Peisen Su: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Xuefeng Li: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Guiping Wang: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Cunyao Bo: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Xiaojian Fang: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. ORCID
Wenwen Zhuang: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Xinxin Cheng: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Jianwen Wu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Luhao Dong: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Wuying Chen: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Wen Li: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Guilian Xiao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Jinxiao Zhao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Yongchao Hao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Ying Xu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Yu Gao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Wenjing Liu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Yanhe Liu: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Huayan Yin: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Jiazhu Li: College of Chemistry and Chemical Engineering, Yantai University, Yantai, Shandong 264005, PR China. ORCID
Xiang Li: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Yan Zhao: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Xiaoqian Wang: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Fei Ni: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. ORCID
Xin Ma: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Anfei Li: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China.
Steven S Xu: USDA-ARS, Cereal Crops Research Unit, Edward T. Schafer Agricultural Research Center, Fargo, ND 58102, USA. ORCID
Guihua Bai: USDA-ARS, Hard Winter Wheat Genetics Research Unit, Manhattan, KS 66506, USA. ORCID
Eviatar Nevo: Institute of Evolution, University of Haifa, Mount Carmel, Haifa 3498838, Israel.
Caixia Gao: State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, PR China. ORCID
Herbert Ohm: Department of Agronomy, Purdue University, West Lafayette, IN 47907, USA.
Lingrang Kong: State Key Laboratory of Crop Biology, College of Agronomy, Shandong Agricultural University, Tai'an, Shandong 271018, PR China. lkong@sdau.edu.cn wanghongwei@sdau.edu.cn. ORCID
head blight (FHB), a fungal disease caused by species that produce food toxins, currently devastates wheat production worldwide, yet few resistance resources have been discovered in wheat germplasm. Here, we cloned the FHB resistance gene by assembling the genome of , a species used in wheat distant hybridization breeding. encodes a glutathione S-transferase (GST) and confers broad resistance to species by detoxifying trichothecenes through de-epoxidation. GST homologs are absent in plants, and our evidence supports that has gained through horizontal gene transfer (HGT) from an endophytic species. introgressions in wheat confers resistance to both FHB and crown rot in diverse wheat backgrounds without yield penalty, providing a solution for resistance breeding.
