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06 25, 2020;9 (6):

Circular RNAs in Sepsis: Biogenesis, Function, and Clinical Significance.

Jesús Beltrán-García, Rebeca Osca-Verdegal, Elena Nacher-Sendra, Federico V Pallardó, José Luis García-Giménez
Author Information
  1. Jesús Beltrán-García: Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain.
  2. Rebeca Osca-Verdegal: Instituto de Investigación Sanitaria INCLIVA, 46010 Valencia, Spain.
  3. Elena Nacher-Sendra: Departamento de Fisiología, Facultad de Medicina y Odontología, Universitat de València, 46010 València, Spain.
  4. Federico V Pallardó: Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain. ORCID
  5. José Luis García-Giménez: Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, 28029 Madrid, Spain. ORCID
PMID: 32630422 DOI: 10.3390/cells9061544

Abstract

Sepsis is a life-threatening condition that occurs when the body responds to an infection that damages it is own tissues. The major problem in sepsis is rapid, vital status deterioration in patients, which can progress to septic shock with multiple organ failure if not properly treated. As there are no specific treatments, early diagnosis is mandatory to reduce high mortality. Despite more than 170 different biomarkers being postulated, early sepsis diagnosis and prognosis remain a challenge for clinicians. Recent findings propose that circular RNAs (circRNAs) may play a prominent role in regulating the patients' immune system against different pathogens, including bacteria and viruses. Mounting evidence also suggests that the misregulation of circRNAs is an early event in a wide range of diseases, including sepsis. Despite circRNA levels being altered in sepsis, the specific mechanisms controlling the dysregulation of these noncoding RNAs are not completely elucidated, although many factors are known to affect circRNA biogenesis. Therefore, there is a need to explore the molecular pathways that lead to this disorder. This review describes the role of this new class of regulatory RNAs in sepsis and the feasibility of using circRNAs as diagnostic biomarkers for sepsis, opening up new avenues for circRNA-based medicine.

Keywords

alternative splicing biomarker circular RNAs (circRNAs) epigenetics sepsis transcription

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MeSH Term

Alternative Splicing
Biomarkers
Humans
RNA, Circular
Sepsis

Chemicals

Biomarkers
RNA, Circular
Journal Article Research Support, Non-U.S. Gov't Review

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