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09, 2020;11 (9): 680-687.

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients.

Jiangping He, Shuijiang Cai, Huijian Feng, Baomei Cai, Lihui Lin, Yuanbang Mai, Yinqiang Fan, Airu Zhu, Huang Huang, Junjie Shi, Dingxin Li, Yuanjie Wei, Yueping Li, Yingying Zhao, Yuejun Pan, He Liu, Xiaoneng Mo, Xi He, Shangtao Cao, FengYu Hu, Jincun Zhao, Jie Wang, Nanshan Zhong, Xinwen Chen, Xilong Deng, Jiekai Chen
Author Information
  1. Jiangping He: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  2. Shuijiang Cai: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  3. Huijian Feng: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  4. Baomei Cai: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  5. Lihui Lin: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  6. Yuanbang Mai: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  7. Yinqiang Fan: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  8. Airu Zhu: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  9. Huang Huang: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  10. Junjie Shi: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  11. Dingxin Li: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  12. Yuanjie Wei: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  13. Yueping Li: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  14. Yingying Zhao: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  15. Yuejun Pan: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  16. He Liu: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  17. Xiaoneng Mo: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  18. Xi He: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  19. Shangtao Cao: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  20. FengYu Hu: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China.
  21. Jincun Zhao: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  22. Jie Wang: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.
  23. Nanshan Zhong: State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
  24. Xinwen Chen: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_xinwen@gibh.ac.cn.
  25. Xilong Deng: Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, 510060, China. gz8hdxl@126.com.
  26. Jiekai Chen: Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China. chen_jiekai@gibh.ac.cn.
PMID: 32671793 DOI: 10.1007/s13238-020-00752-4

Abstract

No abstract text available.

References

  1. Nat Med. 2020 Feb;26(2):244-251 [PMID: 31959991]
  2. Carcinogenesis. 2018 May 3;39(5):633-651 [PMID: 29415129]
  3. Virol J. 2019 Apr 3;16(1):44 [PMID: 30944006]
  4. Adv Colloid Interface Sci. 2018 Feb;252:69-82 [PMID: 29329667]
  5. Fa Yi Xue Za Zhi. 2020 Feb;36(1):21-23 [PMID: 32198987]
  6. Int Rev Cell Mol Biol. 2013;303:139-202 [PMID: 23445810]
  7. Cold Spring Harb Perspect Biol. 2017 Apr 3;9(4): [PMID: 27864314]
  8. Nature. 2011 Jun 08;475(7355):222-5 [PMID: 21654748]
  9. Natl Sci Rev. 2020 Sep;7(9):1414-1418 [PMID: 34192086]
  10. Nat Med. 2020 Jun;26(6):842-844 [PMID: 32398875]
  11. N Engl J Med. 2010 Dec 2;363(23):2233-47 [PMID: 21121836]
  12. Annu Rev Physiol. 2015;77:379-406 [PMID: 25386990]
  13. Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536 [PMID: 30554520]
  14. Lancet Rheumatol. 2020 Jun;2(6):e325-e331 [PMID: 32501454]

MeSH Term

Betacoronavirus
COVID-19
Coronavirus Infections
Humans
Pandemics
Pneumonia, Viral
SARS-CoV-2
Single-Cell Analysis
Letter Research Support, Non-U.S. Gov't Comment

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