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11 24, 2020;19 (1): 165.

Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities.

Xiufang Xu, Miaofeng Zhang, Faying Xu, Shaojie Jiang
Author Information
  1. Xiufang Xu: School of Medical Imaging, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
  2. Miaofeng Zhang: Department of Orthopedic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310009, Zhejiang, China.
  3. Faying Xu: School of Medical Imaging, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China.
  4. Shaojie Jiang: School of Medical Imaging, Hangzhou Medical College, Hangzhou, 310053, Zhejiang, China. jsj1983@hmc.edu.cn. ORCID
PMID: 33234169 DOI: 10.1186/s12943-020-01276-5

Abstract

Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling embryonic and organ development, as well as cancer progression. Genome-wide sequencing and gene expression profile analyses have demonstrated that Wnt signaling is involved mainly in the processes of breast cancer proliferation and metastasis. The most recent studies have indicated that Wnt signaling is also crucial in breast cancer immune microenvironment regulation, stemness maintenance, therapeutic resistance, phenotype shaping, etc. Wnt/β-Catenin, Wnt-planar cell polarity (PCP), and Wnt-Ca signaling are three well-established Wnt signaling pathways that share overlapping components and play different roles in breast cancer progression. In this review, we summarize the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges, and potential opportunities for advancing the therapy and diagnosis of breast cancer.

Keywords

Breast cancer Canonical/noncanonical Wnt signaling Drug resistance Epithelial-mesenchymal transition Immune microenvironment Phenotype shaping Tumoral heterogeneity

References

Carcinogenesis. 2014 Nov;35(11):2544-54 [PMID: 25194164]
Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):5954-63 [PMID: 21393571]
Br J Cancer. 2008 Nov 18;99(10):1735-42 [PMID: 18841156]
J Biol Chem. 1995 Mar 31;270(13):7420-6 [PMID: 7535770]
Acta Biomater. 2019 Apr 1;88:86-101 [PMID: 30771534]
Cancer Cell. 2015 Apr 13;27(4):547-60 [PMID: 25873176]
Nature. 2020 Feb;578(7796):615-620 [PMID: 31959985]
Biochim Biophys Acta Mol Basis Dis. 2018 Oct;1864(10):3459-3467 [PMID: 30076960]
J Exp Med. 2001 Aug 20;194(4):541-9 [PMID: 11514609]
BMC Cancer. 2018 Feb 22;18(1):219 [PMID: 29471794]
Nat Cell Biol. 2005 Jul;7(7):691-7 [PMID: 15937478]
Science. 1999 Mar 26;283(5410):2089-91 [PMID: 10092233]
Cancer Sci. 2018 Dec;109(12):4003-4014 [PMID: 30238564]
Nat Commun. 2020 Apr 14;11(1):1787 [PMID: 32286297]
Oncogene. 2016 Sep 8;35(36):4787-97 [PMID: 26876203]
Nat Rev Dis Primers. 2019 Sep 23;5(1):66 [PMID: 31548545]
Cell. 2012 Dec 21;151(7):1542-56 [PMID: 23260141]
Nature. 2002 May 16;417(6886):295-9 [PMID: 12015605]
Oncoimmunology. 2018 Feb 15;7(4):e1345415 [PMID: 29632713]
Nat Cell Biol. 2008 Feb;10(2):178-85 [PMID: 18193032]
Mol Cancer Res. 2012 Dec;10(12):1597-606 [PMID: 23071104]
Development. 2003 Sep;130(18):4295-305 [PMID: 12900447]
PLoS One. 2013 Oct 15;8(10):e77425 [PMID: 24143235]
Science. 1997 Mar 21;275(5307):1790-2 [PMID: 9065403]
Nature. 2012 Aug 30;488(7413):665-9 [PMID: 22895187]
Cell. 2019 Aug 8;178(4):949-963.e18 [PMID: 31353221]
Cell. 1996 Aug 9;86(3):391-9 [PMID: 8756721]
Cell. 2008 May 16;133(4):704-15 [PMID: 18485877]
Int J Cancer. 2003 Aug 20;106(2):208-15 [PMID: 12800196]
Cancer Cell. 2004 Jan;5(1):91-102 [PMID: 14749129]
Osteoarthritis Cartilage. 2018 Jan;26(1):18-27 [PMID: 28888902]
Cell. 1995 Jun 30;81(7):1137-46 [PMID: 7600581]
J Exp Clin Cancer Res. 2019 Feb 21;38(1):94 [PMID: 30791958]
Genes Dev. 2014 Oct 15;28(20):2205-18 [PMID: 25260709]
Br J Cancer. 2017 Jun 6;116(12):1595-1603 [PMID: 28472820]
Eur J Surg Oncol. 2000 Dec;26(8):733-7 [PMID: 11087636]
Virchows Arch. 2016 May;468(5):589-95 [PMID: 26874851]
Semin Cell Dev Biol. 2017 Sep;69:102-110 [PMID: 28716607]
N Engl J Med. 2018 Nov 29;379(22):2108-2121 [PMID: 30345906]
Breast Cancer Res Treat. 2012 May;133(1):37-47 [PMID: 21814749]
Nat Rev Cancer. 2017 Apr;17(4):209-222 [PMID: 28233802]
Stem Cells. 2015 Oct;33(10):2913-24 [PMID: 26086949]
Science. 2017 Apr 21;356(6335): [PMID: 28280246]
Trends Cell Biol. 2017 Aug;27(8):556-567 [PMID: 28487183]
Nat Cell Biol. 2006 Dec;8(12):1398-406 [PMID: 17072303]
Dev Cell. 2017 Nov 6;43(3):274-289.e5 [PMID: 29056552]
Science. 2012 Jul 6;337(6090):59-64 [PMID: 22653731]
J Comput Aided Mol Des. 2009 Jan;23(1):37-47 [PMID: 18780146]
Cancer Res. 1994 May 15;54(10):2615-21 [PMID: 8168088]
Carcinogenesis. 2011 Mar;32(3):434-42 [PMID: 21173432]
Nature. 1987 Oct 8-14;329(6139):549-51 [PMID: 3116434]
Nat Commun. 2014 Nov 19;5:5406 [PMID: 25406648]
Nat Rev Cancer. 2009 Sep;9(9):631-43 [PMID: 19701242]
Cancer Res. 1996 Jun 1;56(11):2556-60 [PMID: 8653697]
Nature. 2010 Jun 10;465(7299):803-7 [PMID: 20445538]
J Neurosci. 2006 Feb 22;26(8):2147-56 [PMID: 16495441]
EMBO Rep. 2011 Oct 28;12(11):1144-52 [PMID: 21886182]
Nat Commun. 2016 Feb 04;7:10633 [PMID: 26843124]
Nature. 2011 Jan 20;469(7330):314-22 [PMID: 21248838]
Nat Chem Biol. 2016 Aug;12(8):593-600 [PMID: 27294323]
Alzheimers Dement. 2018 Mar;14(3):306-317 [PMID: 29055813]
Mol Oncol. 2013 Oct;7(5):870-83 [PMID: 23727359]
Cancer Treat Rev. 2018 Sep;69:152-163 [PMID: 30029203]
Cell. 2007 Dec 28;131(7):1378 [PMID: 18160045]
Cell. 2009 Apr 17;137(2):295-307 [PMID: 19379695]
Mol Cell. 2004 Jan 16;13(1):149-56 [PMID: 14731402]
Oncogene. 1997 Mar 13;14(10):1249-53 [PMID: 9121776]
Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):3046-50 [PMID: 7708772]
Cell. 1987 Aug 14;50(4):659-63 [PMID: 2440586]
Bioorg Med Chem Lett. 2016 Dec 15;26(24):5891-5895 [PMID: 27876319]
Cell Res. 2017 Dec;27(12):1466-1484 [PMID: 29056748]
EMBO J. 2019 Dec 2;38(23):e101230 [PMID: 31625188]
Cell. 1982 Nov;31(1):99-109 [PMID: 6297757]
Trends Neurosci. 2010 Feb;33(2):84-92 [PMID: 20004982]
Stem Cell Reports. 2019 Dec 10;13(6):1038-1052 [PMID: 31761677]
Carcinogenesis. 2006 Jul;27(7):1341-8 [PMID: 16501252]
Nature. 1997 Nov 27;390(6658):410-3 [PMID: 9389482]
Nat Rev Immunol. 2018 Jan;18(1):5-18 [PMID: 28920587]
Nat Cell Biol. 2017 Mar;19(3):164-176 [PMID: 28192422]
Theranostics. 2020 May 23;10(15):6898-6914 [PMID: 32550911]
Mol Immunol. 2016 Jul;75:151-60 [PMID: 27289031]
Proc Natl Acad Sci U S A. 2014 Jun 24;111(25):9157-62 [PMID: 24927563]
Nat Cell Biol. 2014 Oct;16(10):1004-15, 1-13 [PMID: 25241036]
Am J Pathol. 2000 Jun;156(6):1997-2005 [PMID: 10854222]
Anticancer Res. 2004 Nov-Dec;24(6):3851-6 [PMID: 15736421]
Breast Cancer Res. 2012 Oct 22;14(5):R134 [PMID: 23088371]
Cancer Cell. 2013 Mar 18;23(3):316-31 [PMID: 23453623]
Cancer. 2003 Aug 1;98(3):474-83 [PMID: 12879463]
Mol Cell. 2002 Sep;10(3):573-84 [PMID: 12408825]
Proc Natl Acad Sci U S A. 2003 Jul 8;100(14):8418-23 [PMID: 12829800]
Breast Cancer Res. 2016 Sep 20;18(1):92 [PMID: 27650553]
BMC Cancer. 2013 Apr 02;13:174 [PMID: 23547709]
Science. 1991 Nov 29;254(5036):1359-61 [PMID: 1962194]
Clin Cancer Res. 1995 Feb;1(2):215-22 [PMID: 9815976]
Genes Dev. 2002 May 1;16(9):1066-76 [PMID: 12000790]
Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5136-41 [PMID: 20194742]
Science. 2000 Jun 16;288(5473):2051-4 [PMID: 10856220]
Nat Commun. 2016 Oct 04;7:12885 [PMID: 27698350]
Mol Cancer Ther. 2016 Jul;15(7):1525-34 [PMID: 27196752]
Oncol Rep. 2005 Dec;14(6):1583-8 [PMID: 16273260]
Oncogene. 2001 Nov 1;20(50):7408-12 [PMID: 11704870]
Mol Cancer Res. 2012 Nov;10(11):1482-95 [PMID: 22952044]
J Cell Biol. 1994 Dec;127(6 Pt 2):2061-9 [PMID: 7806582]
Cancer Res. 2011 Jan 1;71(1):197-205 [PMID: 21199802]
Mol Cancer Ther. 2016 Jul;15(7):1580-90 [PMID: 27207778]
Nat Rev Urol. 2017 Nov;14(11):683-696 [PMID: 28895566]
Chem Biol Drug Des. 2012 Apr;79(4):376-83 [PMID: 22172211]
Br J Cancer. 2008 Mar 25;98(6):1147-56 [PMID: 18283316]
Cell. 2009 Aug 21;138(4):645-659 [PMID: 19682730]
Cell. 2008 Apr 18;133(2):340-53 [PMID: 18423204]
Cell. 2016 Mar 24;165(1):45-60 [PMID: 27015306]
J Biol Chem. 2005 Jul 22;280(29):26770-5 [PMID: 15908424]
Cancer Res. 2008 Feb 15;68(4):989-97 [PMID: 18281472]
J Med Chem. 2013 Oct 24;56(20):7880-9 [PMID: 24116873]
Cell. 2019 Nov 27;179(6):1409-1423.e17 [PMID: 31778655]
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13253-7 [PMID: 21788521]
Nat Commun. 2013;4:1449 [PMID: 23385593]
Cell. 2012 May 25;149(5):1084-97 [PMID: 22632972]
Cell. 2014 Nov 6;159(4):844-56 [PMID: 25417160]
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12919-24 [PMID: 17644613]
Nat Cell Biol. 2008 Feb;10(2):160-9 [PMID: 18193033]
Exp Cell Res. 2006 Jul 15;312(12):2180-94 [PMID: 16630611]
J Med Chem. 2013 Aug 22;56(16):6495-511 [PMID: 23844574]
Nature. 1999 Apr 1;398(6726):431-6 [PMID: 10201374]
Pathol Oncol Res. 2017 Apr;23(2):439-446 [PMID: 28032309]
Oncogene. 2000 Jun 15;19(26):3013-20 [PMID: 10871853]
Nature. 2012 Apr 29;485(7397):195-200 [PMID: 22575959]
Gene Expr Patterns. 2004 Nov;5(1):97-105 [PMID: 15533824]
Mol Cancer. 2017 Feb 16;16(1):41 [PMID: 28209166]
Nat Rev Drug Discov. 2018 Dec;17(12):887-904 [PMID: 30361552]
Cancer Res. 2013 Jan 15;73(2):502-7 [PMID: 23188502]
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8 [PMID: 12629218]
Cell. 1999 Sep 3;98(5):585-95 [PMID: 10490098]
Cancer Cell. 2003 Nov;4(5):349-60 [PMID: 14667502]
Oncotarget. 2015 Dec 1;6(38):41307-23 [PMID: 26513298]
Mol Cancer. 2008 Nov 06;7:83 [PMID: 18990230]
Nat Rev Cancer. 2007 Oct;7(10):791-9 [PMID: 17851544]
J Cell Biol. 2001 Jul 23;154(2):369-87 [PMID: 11470825]
Nature. 2019 May;569(7757):560-564 [PMID: 31118521]
Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18598-603 [PMID: 19841259]
BMC Biochem. 2005 Aug 04;6:13 [PMID: 16080788]
Nature. 2019 Nov;575(7782):299-309 [PMID: 31723286]
Nat Rev Urol. 2015 Nov;12(11):597 [PMID: 26439505]
Clin Cancer Res. 2005 Jan 15;11(2 Pt 1):520-8 [PMID: 15701836]
Nature. 2009 Oct 1;461(7264):614-20 [PMID: 19759537]
EBioMedicine. 2015 Oct 08;2(11):1751-8 [PMID: 26870800]
Nature. 2003 May 22;423(6938):448-52 [PMID: 12717451]
Nature. 2001 May 17;411(6835):321-5 [PMID: 11357136]
Nature. 1998 Oct 8;395(6702):604-8 [PMID: 9783586]
Nature. 2006 Sep 21;443(7109):345-9 [PMID: 16988714]
Nature. 2011 Feb 24;470(7335):548-53 [PMID: 21326202]
Nature. 2000 Sep 28;407(6803):530-5 [PMID: 11029007]
Cancer Res. 2014 Jun 1;74(11):2962-73 [PMID: 24638982]
Cell Stem Cell. 2010 Jun 4;6(6):568-77 [PMID: 20569694]
Bioorg Med Chem. 2016 Nov 15;24(22):5861-5872 [PMID: 27692509]
Breast Cancer Res Treat. 2011 May;127(1):99-108 [PMID: 20556505]
Clin Cancer Res. 2013 May 15;19(10):2723-33 [PMID: 23549873]
Int J Oncol. 2005 Oct;27(4):949-56 [PMID: 16142310]
Cell Rep. 2018 May 29;23(9):2559-2567 [PMID: 29847788]
PLoS One. 2014 Jan 07;9(1):e84472 [PMID: 24409301]
Tumour Biol. 2013 Jun;34(3):1625-33 [PMID: 23417837]
Trends Pharmacol Sci. 2018 Jul;39(7):648-658 [PMID: 29678298]
Nature. 2005 Dec 8;438(7069):867-72 [PMID: 16341016]
Breast Cancer Res Treat. 2019 Nov;178(2):347-356 [PMID: 31399931]
Development. 2006 Dec;133(24):4901-11 [PMID: 17108000]
Breast Cancer Res. 2015 Sep 17;17:128 [PMID: 26384318]
Nat Rev Mol Cell Biol. 2006 Feb;7(2):131-42 [PMID: 16493418]
Breast Cancer Res Treat. 2006 Sep;99(1):85-90 [PMID: 16541313]
Science. 1997 Mar 21;275(5307):1787-90 [PMID: 9065402]
Cell. 1999 Jul 23;98(2):137-46 [PMID: 10428026]
Science. 2007 May 18;316(5827):1043-6 [PMID: 17510365]
Nature. 2000 Aug 17;406(6797):747-52 [PMID: 10963602]
Clin Cancer Res. 2008 Jan 1;14(1):55-61 [PMID: 18172252]
Science. 2018 Jun 29;360(6396): [PMID: 29773667]
Breast Cancer Res. 2010;12(5):R68 [PMID: 20813035]
Drug Metab Dispos. 2011 Mar;39(3):558-62 [PMID: 21148080]
J Cancer Res Clin Oncol. 2015 Feb;141(2):243-54 [PMID: 25209439]
Nat Neurosci. 2009 Jul;12(7):829-38 [PMID: 19503085]
Physiol Rev. 2020 Apr 1;100(2):489-523 [PMID: 31539305]
Cancer Res. 2015 Apr 15;75(8):1691-702 [PMID: 25660951]
Oncogene. 2006 Jul 20;25(31):4361-9 [PMID: 16532032]
Cancer Res. 2010 Nov 15;70(22):9298-308 [PMID: 20870744]
Curr Biol. 1998 May 7;8(10):573-81 [PMID: 9601641]
Front Microbiol. 2018 Jul 02;9:1448 [PMID: 30013542]
Nature. 1998 Oct 8;395(6702):608-12 [PMID: 9783587]
Molecules. 2018 Dec 23;24(1): [PMID: 30583594]
Int J Oncol. 2004 Nov;25(5):1337-42 [PMID: 15492823]
J Biol Chem. 2004 Apr 23;279(17):17232-40 [PMID: 14960582]
Cancer Res. 2019 Mar 1;79(5):982-993 [PMID: 30563890]
J Med Chem. 2013 Apr 11;56(7):3012-23 [PMID: 23473363]
J Pathol. 2002 Feb;196(2):145-53 [PMID: 11793365]
Breast Cancer Res Treat. 2013 Feb;138(1):81-90 [PMID: 23412770]
Nature. 2015 Jan 1;517(7532):81-4 [PMID: 25327250]
Cell Rep. 2016 Jun 28;16(1):28-36 [PMID: 27320923]
Nat Commun. 2016 Jan 12;7:10318 [PMID: 26754771]
Curr Opin Genet Dev. 2014 Aug;27:14-9 [PMID: 24791688]
Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11717-22 [PMID: 22753465]
Sci Transl Med. 2012 Aug 22;4(148):148ra117 [PMID: 22914623]
Breast Cancer Res Treat. 2013 May;139(1):95-105 [PMID: 23580071]
Nat Rev Mol Cell Biol. 2019 Feb;20(2):69-84 [PMID: 30459476]
PLoS One. 2012;7(12):e50457 [PMID: 23227175]
Neuron. 2009 Mar 12;61(5):721-33 [PMID: 19285469]
Cancer Res. 1997 Oct 1;57(19):4267-73 [PMID: 9331087]
Nature. 2019 Aug;572(7769):392-396 [PMID: 31367043]
Nat Genet. 2000 Jul;25(3):329-32 [PMID: 10888884]
Nat Commun. 2016 Jan 18;7:10305 [PMID: 26777421]
PLoS One. 2012;7(3):e33976 [PMID: 22470504]
Cancer Cell. 2014 Feb 10;25(2):210-25 [PMID: 24525235]
Clin Cancer Res. 2008 Jul 1;14(13):4038-44 [PMID: 18593979]
Genet Res (Camb). 2019 Dec 27;101:e14 [PMID: 31878985]
Nature. 2000 Sep 28;407(6803):527-30 [PMID: 11029006]
Cancer Cell. 2007 Mar;11(3):259-73 [PMID: 17349583]
Nat Med. 2014 Nov;20(11):1279-88 [PMID: 25306233]
Dev Cell. 2005 Aug;9(2):283-92 [PMID: 16054034]
Biomed Pharmacother. 2017 Sep;93:359-369 [PMID: 28651237]
Biochemistry. 2012 Jan 17;51(2):724-31 [PMID: 22224445]
Bioorg Med Chem. 2015 Sep 1;23(17):5829-38 [PMID: 26272032]
Oncotarget. 2017 Sep 6;8(53):91459-91470 [PMID: 29207657]
Cancer Res. 2013 Jun 15;73(12):3649-60 [PMID: 23771907]
PLoS One. 2012;7(11):e48670 [PMID: 23144924]
Mol Cell Biol. 1996 Mar;16(3):1247-55 [PMID: 8622669]
CA Cancer J Clin. 2019 Nov;69(6):438-451 [PMID: 31577379]
Nat Rev Clin Oncol. 2009 Jun;6(6):311-2 [PMID: 19483736]
Cancer Discov. 2011 Jun;1(1):54-67 [PMID: 22039576]
Nat Rev Immunol. 2005 Jan;5(1):21-30 [PMID: 15630426]
Organogenesis. 2008 Apr;4(2):68-75 [PMID: 19279717]
Br J Cancer. 2009 Jul 21;101(2):278-86 [PMID: 19536088]
Cell Stem Cell. 2007 Nov;1(5):555-67 [PMID: 18371393]
Ann Surg Oncol. 2005 Jun;12(6):488-96 [PMID: 15864483]
Nat Med. 2009 Aug;15(8):907-13 [PMID: 19648928]
Cancer Cell. 2010 Jul 13;18(1):74-87 [PMID: 20609354]
Cancer Lett. 2004 Dec 8;216(1):81-7 [PMID: 15500951]
Cell. 2009 Oct 16;139(2):299-311 [PMID: 19837033]
Nature. 2000 Sep 28;407(6803):535-8 [PMID: 11029008]
J Neurochem. 2007 Sep;102(5):1426-1446 [PMID: 17697045]
Angew Chem Int Ed Engl. 2009;48(35):6448-52 [PMID: 19637179]
J Cell Physiol. 2011 Feb;226(2):542-51 [PMID: 20683915]
Development. 2012 Mar;139(5):1023-33 [PMID: 22318632]
Clin Cancer Res. 2007 Jan 1;13(1):90-101 [PMID: 17200343]
Bioorg Med Chem. 2018 Nov 1;26(20):5435-5442 [PMID: 30274939]
Clin Cancer Res. 2006 Sep 15;12(18):5395-402 [PMID: 17000672]
Cancer Biol Ther. 2006 Mar;5(3):281-6 [PMID: 16410723]
J Med Chem. 2019 Sep 12;62(17):7897-7909 [PMID: 31381853]
J Biol Chem. 2015 Dec 18;290(51):30596-606 [PMID: 26504084]
EMBO Mol Med. 2013 Feb;5(2):264-79 [PMID: 23307470]
Breast Cancer Res Treat. 2012 Sep;135(2):459-67 [PMID: 22842982]
Arthritis Rheum. 2005 Jan;52(1):201-11 [PMID: 15641052]
Nature. 1989 Mar 16;338(6212):263-4 [PMID: 2493583]
Mol Cancer Ther. 2011 Mar;10(3):448-60 [PMID: 21224390]
Nat Commun. 2018 May 15;9(1):1908 [PMID: 29765039]
Cold Spring Harb Perspect Biol. 2012 May 01;4(5): [PMID: 22550232]
Anticancer Res. 2013 Sep;33(9):3759-63 [PMID: 24023307]
Cell Metab. 2012 Nov 7;16(5):625-33 [PMID: 23140642]
Science. 2016 Apr 8;352(6282):227-31 [PMID: 26966191]
Nat Cell Biol. 2006 May;8(5):492-500 [PMID: 16604063]
J Biol Chem. 2003 Nov 28;278(48):48137-45 [PMID: 12972427]
Cancer Res. 2018 Jul 1;78(13):3698-3708 [PMID: 29735553]
Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16654-9 [PMID: 23011797]
Nat Rev Drug Discov. 2014 Jul;13(7):513-32 [PMID: 24981364]
Biochemistry. 2009 Nov 3;48(43):10267-74 [PMID: 19772353]
J Clin Invest. 2012 Apr;122(4):1469-86 [PMID: 22406531]
Cell. 1987 Aug 14;50(4):649-57 [PMID: 3111720]
Nat Rev Mol Cell Biol. 2014 Mar;15(3):178-96 [PMID: 24556840]
EMBO J. 1995 Dec 15;14(24):6107-15 [PMID: 8557030]
Cell Stem Cell. 2018 Mar 1;22(3):414-427.e6 [PMID: 29499154]
Front Oncol. 2017 Sep 04;7:184 [PMID: 28929082]
J Med Chem. 2013 Mar 28;56(6):2700-4 [PMID: 23477365]
Biochem J. 2005 Jul 1;389(Pt 1):127-35 [PMID: 15850461]
Chin J Cancer Res. 2011 Sep;23(3):201-7 [PMID: 23467396]
Nature. 2008 Jul 17;454(7202):345-9 [PMID: 18528331]
Nat Cell Biol. 2008 Feb;10(2):170-7 [PMID: 18193037]
PLoS One. 2011;6(6):e20702 [PMID: 21695190]
Development. 1999 Jun;126(14):3159-70 [PMID: 10375506]
J Biol Chem. 1999 Jun 4;274(23):16180-7 [PMID: 10347172]
Cancer Res. 2012 Jun 1;72(11):2822-32 [PMID: 22440753]
Cell Death Dis. 2020 May 21;11(5):384 [PMID: 32439916]
Cell. 2002 Mar 22;108(6):837-47 [PMID: 11955436]
Mod Pathol. 2011 Feb;24(2):209-31 [PMID: 21076461]
Cell. 2006 May 5;125(3):509-22 [PMID: 16678095]
Nature. 2006 Jan 12;439(7073):220-4 [PMID: 16407953]
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63 [PMID: 9096311]
J Clin Oncol. 2010 Apr 1;28(10):1684-91 [PMID: 20194857]
Trends Genet. 2004 Nov;20(11):570-7 [PMID: 15475117]
Nat Med. 2017 Jan;23(1):60-68 [PMID: 27869803]
JAMA Oncol. 2019 Aug 01;5(8):1205-1214 [PMID: 30973611]
Nat Genet. 2009 Jul;41(7):793-9 [PMID: 19543268]
Cells. 2019 Aug 14;8(8): [PMID: 31416135]
Cancer Sci. 2012 Feb;103(2):210-20 [PMID: 22026417]
Science. 1993 Dec 10;262(5140):1731-4 [PMID: 8259518]
Am J Pathol. 2010 Jun;176(6):2911-20 [PMID: 20395444]
Dev Cell. 2002 May;2(5):655-66 [PMID: 12015972]
Nat Rev Clin Oncol. 2019 Jun;16(6):356-371 [PMID: 30705439]
N Engl J Med. 2010 Nov 11;363(20):1938-48 [PMID: 21067385]
Cell. 2002 Apr 5;109(1):47-60 [PMID: 11955446]
Nature. 2001 Jul 5;412(6842):86-90 [PMID: 11452312]
Nature. 2015 Mar 12;519(7542):187-192 [PMID: 25731175]
Nat Rev Mol Cell Biol. 2012 Dec;13(12):767-79 [PMID: 23151663]
Nature. 1996 Jul 18;382(6588):225-30 [PMID: 8717036]
Genes Chromosomes Cancer. 2000 Aug;28(4):443-53 [PMID: 10862053]
Oncogene. 2019 May;38(21):4047-4060 [PMID: 30705400]
Nucleic Acids Res. 2018 Feb 16;46(3):1180-1195 [PMID: 29186616]
Cell Stem Cell. 2013 Sep 5;13(3):300-13 [PMID: 23871604]
Genes Dev. 1996 Jun 15;10(12):1443-54 [PMID: 8666229]
Cancer Res. 2007 Jan 15;67(2):573-9 [PMID: 17234765]
J Pathol. 2012 Nov;228(3):300-9 [PMID: 22926799]
PLoS Biol. 2006 Apr;4(4):e115 [PMID: 16602827]
Nat Cell Biol. 2019 Sep;21(9):1113-1126 [PMID: 31451770]
Nat Cell Biol. 2017 Oct;19(10):1274-1285 [PMID: 28892080]
Mol Cancer. 2017 Mar 7;16(1):57 [PMID: 28270211]
Cell. 2004 Mar 19;116(6):883-95 [PMID: 15035989]
Science. 2010 Jan 22;327(5964):459-63 [PMID: 20093472]
EMBO J. 1998 Mar 2;17(5):1371-84 [PMID: 9482734]
Cell Stem Cell. 2012 Sep 7;11(3):387-400 [PMID: 22863533]
Carcinogenesis. 2014 Oct;35(10):2346-56 [PMID: 25085904]
Cancer Res. 2009 Jul 1;69(13):5364-73 [PMID: 19549913]
Nature. 2015 Jun 18;522(7556):345-348 [PMID: 25822788]
Oncogene. 2011 Oct 27;30(43):4437-46 [PMID: 21532620]
Bioorg Med Chem Lett. 2009 Sep 1;19(17):4980-3 [PMID: 19640711]
Genes Dev. 2007 Jun 15;21(12):1478-83 [PMID: 17575049]
Sci Transl Med. 2017 Jan 11;9(372): [PMID: 28077676]
Mol Cell. 2001 Apr;7(4):801-9 [PMID: 11336703]
J Pathol. 1997 Dec;183(4):404-11 [PMID: 9496256]
Nature. 1998 Jan 22;391(6665):357-62 [PMID: 9450748]
Cancer Discov. 2015 May;5(5):520-33 [PMID: 25735774]
Ann Rheum Dis. 2019 Apr;78(4):551-561 [PMID: 30745310]
Med Oncol. 2015 May;32(5):140 [PMID: 25801232]
Front Cell Dev Biol. 2020 Jan 31;8:25 [PMID: 32083079]
PLoS One. 2013 Jun 06;8(6):e65404 [PMID: 23762361]
Ann Rheum Dis. 2017 Jan;76(1):218-226 [PMID: 27147711]
Histopathology. 1996 Aug;29(2):139-46 [PMID: 8872147]
Mol Cell Biol. 2000 Sep;20(18):6882-90 [PMID: 10958684]
J Biol Chem. 2009 Jun 12;284(24):16256-16263 [PMID: 19383605]
Cell Commun Signal. 2018 May 24;16(1):23 [PMID: 29793495]
Cold Spring Harb Perspect Biol. 2013 Mar 01;5(3):a015081 [PMID: 23085770]
Cold Spring Harb Perspect Biol. 2013 Jan 01;5(1):a007898 [PMID: 23169527]
Int J Oncol. 2007 Feb;30(2):357-63 [PMID: 17203217]
Cell. 2009 Oct 16;139(2):393-404 [PMID: 19837038]
Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3799-804 [PMID: 16501043]
Breast Cancer Res Treat. 2011 Nov;130(2):645-55 [PMID: 21717105]
Nature. 2015 Nov 26;527(7579):472-6 [PMID: 26560033]
Breast Cancer Res Treat. 2017 Jun;163(3):449-460 [PMID: 28337662]
Elife. 2017 May 02;6: [PMID: 28463110]
Proteins. 2006 Jul 1;64(1):60-7 [PMID: 16568448]
Leukemia. 2015 Jun;29(6):1267-78 [PMID: 25482131]
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15853-8 [PMID: 14668450]
Cancer Discov. 2019 Jan;9(1):96-113 [PMID: 30361447]
Nat Rev Immunol. 2008 Aug;8(8):581-93 [PMID: 18617885]
Nat Commun. 2019 Mar 29;10(1):1402 [PMID: 30926793]
Cell. 2009 Nov 25;139(5):871-90 [PMID: 19945376]
Int J Mol Sci. 2018 May 22;19(5): [PMID: 29789460]
Oncogene. 2017 Aug 17;36(33):4692-4705 [PMID: 28394344]
Cancer Immunol Res. 2017 Jul;5(7):516-523 [PMID: 28619968]
Nat Cell Biol. 2004 Jul;6(7):626-33 [PMID: 15208637]
Cancer Res. 2002 Jan 15;62(2):409-16 [PMID: 11809689]
Oncogene. 2016 Apr 28;35(17):2197-207 [PMID: 26257057]
Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12682-7 [PMID: 15314234]
J Pathol. 2014 Jan;232(2):142-50 [PMID: 24114677]
Nature. 1999 Feb 25;397(6721):707-10 [PMID: 10067895]
Dev Cell. 2014 May 12;29(3):277-91 [PMID: 24768165]
Nature. 2007 Oct 25;449(7165):1003-7 [PMID: 17934449]
BMC Cancer. 2018 Jun 8;18(1):646 [PMID: 29884132]
EMBO J. 2000 Apr 17;19(8):1839-50 [PMID: 10775268]
Nat Rev Mol Cell Biol. 2018 Dec;19(12):774-790 [PMID: 30425324]
Proc Natl Acad Sci U S A. 2001 Sep 11;98(19):10869-74 [PMID: 11553815]
Nature. 2003 Apr 24;422(6934):905-9 [PMID: 12712206]
ACS Med Chem Lett. 2016 May 10;7(7):676-80 [PMID: 27437076]
Curr Biol. 2003 Jul 1;13(13):1129-33 [PMID: 12842012]
Nature. 2013 Sep 19;501(7467):355-64 [PMID: 24048068]
Nat Cell Biol. 2019 Jun;21(6):721-730 [PMID: 31110287]
Cell Stem Cell. 2011 Feb 4;8(2):149-63 [PMID: 21295272]
Mol Ther. 2019 Sep 4;27(9):1558-1567 [PMID: 31350188]
Nat Neurosci. 2005 Oct;8(10):1301-9 [PMID: 16172602]
Dev Biol. 1994 Dec;166(2):543-56 [PMID: 7529201]
Nat Rev Immunol. 2019 Mar;19(3):154-169 [PMID: 30622345]
Nat Rev Mol Cell Biol. 2017 Jun;18(6):375-388 [PMID: 28293032]
J Biol Chem. 2010 Jun 18;285(25):19173-83 [PMID: 20395295]
EMBO Mol Med. 2014 Jan;6(1):66-79 [PMID: 24178749]
Life Sci. 2008 Aug 29;83(9-10):318-25 [PMID: 18662704]
J Clin Oncol. 2011 May 20;29(15):1949-55 [PMID: 21483002]
Nat Cell Biol. 2014 Nov;16(11):1092-104 [PMID: 25344754]
Cell Rep. 2012 Nov 29;2(5):1448-60 [PMID: 23103164]
Nature. 2003 May 8;423(6936):173-7 [PMID: 12724779]
Curr Biol. 2004 Nov 23;14(22):2046-51 [PMID: 15556868]
Clin Exp Metastasis. 2009;26(3):205-13 [PMID: 19112599]
Nature. 2019 Aug;572(7770):538-542 [PMID: 31367040]
Cancer Res. 2015 May 15;75(10):1972-82 [PMID: 25769722]
Nat Chem Biol. 2010 Nov;6(11):829-36 [PMID: 20890287]
Annu Rev Cell Dev Biol. 2015;31:623-46 [PMID: 26566118]
Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4158-63 [PMID: 15020770]
Cancer Manag Res. 2019 Mar 18;11:2203-2214 [PMID: 31114314]
J Biol Chem. 2006 Feb 3;281(5):2740-9 [PMID: 16330545]
Nat Chem Biol. 2009 Feb;5(2):100-7 [PMID: 19125156]
Cell. 2004 Jun 25;117(7):927-39 [PMID: 15210113]
Mol Pharmacol. 2001 Dec;60(6):1399-406 [PMID: 11723248]
Mol Cell. 2001 May;7(5):927-36 [PMID: 11389840]
Clin Cancer Res. 2008 Oct 15;14(20):6556-63 [PMID: 18927296]
Nature. 2005 Mar 3;434(7029):88-93 [PMID: 15744305]
Nat Cell Biol. 2004 Oct;6(10):931-40 [PMID: 15448698]
Cell. 2019 May 16;177(5):1330-1345.e18 [PMID: 30982598]
Cell. 1984 Nov;39(1):233-40 [PMID: 6091914]
Cancer Res. 2004 Jan 15;64(2):612-21 [PMID: 14744776]
Breast Cancer Res. 2014 Oct 07;16(5):450 [PMID: 25287138]
Cell. 1997 Jul 11;90(1):181-92 [PMID: 9230313]
Clin Cancer Res. 2018 Oct 1;24(19):4820-4833 [PMID: 29921731]
Nat Rev Cancer. 2012 Mar 22;12(4):252-64 [PMID: 22437870]
Mol Cell. 2003 Jun;11(6):1445-56 [PMID: 12820959]
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Feb 1;68(Pt 2):115-8 [PMID: 22297980]
Nature. 2004 Jul 1;430(6995):93-8 [PMID: 15229603]
Nature. 2014 Apr 3;508(7494):113-7 [PMID: 24695311]
Nature. 1996 Aug 15;382(6592):638-42 [PMID: 8757136]
Pflugers Arch. 2008 Nov;457(2):405-15 [PMID: 18536932]
Cancer Res. 2013 May 15;73(10):3132-44 [PMID: 23539443]
Bioorg Med Chem. 2016 Aug 1;24(15):3259-66 [PMID: 27112452]
Mol Cancer. 2014 Jul 17;13:174 [PMID: 25033833]
Nat Commun. 2017 Apr 05;8:14802 [PMID: 28378740]
J Biol Chem. 2009 Aug 21;284(34):23159-68 [PMID: 19553665]
Development. 2003 May;130(10):2129-38 [PMID: 12668627]
Biosci Rep. 2018 Dec 7;38(6): [PMID: 30314996]
Clin Cancer Res. 2017 Dec 15;23(24):7490-7497 [PMID: 28954784]
Genes Dev. 2013 Nov 1;27(21):2305-19 [PMID: 24186977]
Nature. 2006 Jan 5;439(7072):84-8 [PMID: 16397499]
Cancer Res. 2002 Mar 15;62(6):1613-8 [PMID: 11912130]
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1727-33 [PMID: 526911]
Mol Pharmacol. 2006 Sep;70(3):960-6 [PMID: 16735606]
Breast Cancer Res. 2014 Jul 24;16(4):408 [PMID: 25056574]
J Hepatol. 2011 Feb;54(2):288-99 [PMID: 21055837]
Sci Signal. 2017 Jun 27;10(485): [PMID: 28655862]
Nat Rev Mol Cell Biol. 2020 Jun;21(6):341-352 [PMID: 32300252]
Clin Cancer Res. 2020 May 15;26(10):2284-2289 [PMID: 32001481]
Mol Pharmacol. 1997 May;51(5):741-54 [PMID: 9145912]
J Clin Oncol. 2010 Jun 1;28(16):2768-76 [PMID: 20439629]
Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):20224-9 [PMID: 24277854]
Science. 2010 Jan 29;327(5965):542-5 [PMID: 20110496]
Nat Rev Cancer. 2009 Apr;9(4):265-73 [PMID: 19262571]
Cancer Metastasis Rev. 2009 Jun;28(1-2):151-66 [PMID: 19153669]
J Invest Dermatol. 2008 Dec;128(12):2870-9 [PMID: 18563180]
Int Immunol. 1993 Sep;5(9):1119-28 [PMID: 7902129]
Cell Commun Signal. 2019 Aug 28;17(1):109 [PMID: 31462314]
Breast Cancer Res. 2011 Oct 27;13(5):R106 [PMID: 22032690]
Oncogene. 2006 Jun 8;25(24):3479-88 [PMID: 16449975]
Clin Cancer Res. 2017 Jun 15;23(12):3061-3071 [PMID: 27852699]
Cancer Lett. 2012 Oct 1;323(1):106-113 [PMID: 22484497]
Nat Rev Cancer. 2009 Aug;9(8):576-86 [PMID: 19629072]
Nat Chem Biol. 2018 Jun;14(6):582-590 [PMID: 29632413]
Trends Cancer. 2015 Dec 1;1(4):242-251 [PMID: 26753176]
Neuron. 2002 Aug 1;35(3):489-505 [PMID: 12165471]
PLoS One. 2012;7(3):e31127 [PMID: 22403610]
Dev Cell. 2015 Mar 23;32(6):719-30 [PMID: 25771893]
Mol Cell. 2003 Nov;12(5):1251-60 [PMID: 14636582]
Nat Cell Biol. 2012 Oct;14(10):1036-45 [PMID: 22983114]
Cancer Res. 1996 Oct 1;56(19):4320-3 [PMID: 8813115]
Proc Natl Acad Sci U S A. 2004 Jun 22;101(25):9277-81 [PMID: 15169958]
Nature. 2015 Jul 9;523(7559):231-5 [PMID: 25970248]
EMBO Rep. 2011 Dec 01;12(12):1265-72 [PMID: 22094269]
Cancer Invest. 2008 Feb;26(1):1-10 [PMID: 18181038]
Dev Cell. 2011 Mar 15;20(3):303-14 [PMID: 21397842]
Cancer Res. 1997 Jul 15;57(14):2909-15 [PMID: 9230200]
Cancer Res. 2010 Jul 15;70(14):5963-73 [PMID: 20610623]
Genome Biol. 2007;8(5):R76 [PMID: 17493263]
Theranostics. 2018 Apr 9;8(10):2739-2751 [PMID: 29774072]
Cancer Res. 2003 Apr 15;63(8):1906-13 [PMID: 12702582]
J Pathol. 2017 Feb;241(3):350-361 [PMID: 27859262]
J Biol Chem. 2010 Apr 23;285(17):13154-69 [PMID: 20177055]
Cell. 1994 Mar 25;76(6):1025-37 [PMID: 8137421]
Science. 1997 Mar 21;275(5307):1784-7 [PMID: 9065401]
N Engl J Med. 2019 Jan 3;380(1):33-44 [PMID: 30415629]
Sci Immunol. 2019 Jan 11;4(31): [PMID: 30635355]
J Neurosci. 2015 Jul 15;35(28):10154-67 [PMID: 26180192]
J Biol Chem. 1991 Mar 5;266(7):4514-20 [PMID: 1999432]
Cancer Res. 2016 Feb 15;76(4):891-901 [PMID: 26645562]
Carcinogenesis. 2008 May;29(5):991-8 [PMID: 18356147]
Nature. 2005 Dec 8;438(7069):873-7 [PMID: 16341017]
Nature. 2011 Jun 08;474(7350):220-4 [PMID: 21654806]
J Clin Invest. 2011 Jul;121(7):2750-67 [PMID: 21633166]
Elife. 2018 Jul 31;7: [PMID: 30060804]
Nature. 2006 Aug 10;442(7103):688-91 [PMID: 16799568]
EMBO Mol Med. 2016 Mar 31;8(4):375-87 [PMID: 26941261]
Adv Drug Deliv Rev. 2003 Jan 21;55(1):3-29 [PMID: 12535572]
Biochim Biophys Acta. 2013 Mar;1833(3):752-60 [PMID: 23266555]
Nature. 2016 Dec 22;540(7634):588-592 [PMID: 27974798]
EMBO J. 1989 Jun;8(6):1711-7 [PMID: 2788574]
Cell. 2017 Jun 1;169(6):985-999 [PMID: 28575679]

MeSH Term

Animals
Antineoplastic Agents
Breast Neoplasms
Female
Humans
Tumor Microenvironment
Wnt Signaling Pathway

Chemicals

Antineoplastic Agents
Journal Article Research Support, Non-U.S. Gov't Review

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