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International journal of immunogenetics
Jun, 2021;48 (3): 229-238.

Distribution of HLA-DQA1, -DQB1 and -DRB1 genes and haplotypes in Han, Uyghur, Kazakh and Hui populations inhabiting Xinjiang Uyghur Autonomous Region, China.

Chunyan Zhou, Mengyu Xu, Zhiwen Xiao, Juanli Yuan, Yong Wu, Beiyao Gao, Wenjia Hui, Feng Gao, Hongbing Chen
Author Information
  1. Chunyan Zhou: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
  2. Mengyu Xu: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
  3. Zhiwen Xiao: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China.
  4. Juanli Yuan: School of Pharmaceutical Science, Nanchang University, Nanchang, Jiangxi, China.
  5. Yong Wu: Sino-German Joint Research Institute, Nanchang University, Nanchang, Jiangxi, China.
  6. Beiyao Gao: School of Clinical Medicine, Hainan Medical University, Haikou, Hainan, China.
  7. Wenjia Hui: Department of Gastroenterology, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Uyghur Autonomous Region, China.
  8. Feng Gao: Department of Gastroenterology, People's Hospital of Xinjiang Uyghur Autonomous Region, Urumqi, Xinjiang Uyghur Autonomous Region, China.
  9. Hongbing Chen: State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, Jiangxi, China. ORCID
PMID: 33527680 DOI: 10.1111/iji.12529

Abstract

Genetic polymorphisms of human leucocyte antigen (HLA)-DRB1, -DQA1 and -DQB1 among four main ethnic groups including Han (n = 70), Uyghur (n = 71), Kazakh (n = 52) and Hui (n = 40) subjects from Xinjiang Uyghur Autonomous Region were investigated using a polymerase chain reaction-sequence-based typing (PCR-SBT). In total, 32 HLA-DRB1 alleles, eight HLA-DQA1 alleles and 14 HLA-DQB1 alleles were identified. The most predominant HLA-DRB1, -DQA1 and -DQB1 alleles were DRB1*15:01 (12.50%), DQA1*01:02 (21.43%) and DQB1*03:01 (19.29%) in Han; DRB1*07:01 (18.48%), DQA1*05:01/03/05 (24.65%) and DQB1*02:01/02 (31.69%) in Uyghur; and DRB1*13:01 (13.64%), DQA1*05:01/03/05 (28.85%) and DQB1*02:01/02 (27.88%) in Kazakh, respectively. In Hui, DRB1*07:01, DRB1*11:01 and DRB1*14:01 were the most dominant alleles with the same frequency of 11.8%, while the predominant DQA1 and DQB1 alleles were DQA1*03:01/02/03 (23.75%) and DQB1*02:01/02 (16.25%), respectively. In addition, the most common two-locus haplotypes were DQA1*05:01/03/5-DQB1*03:01 (10.0%) in Han; DQA1*02:01-DQB1*02:01/02 (18.31%) in Uyghur; DQA1*05:01/03/05-DQB1*02:01/02 (15.38%) in Kazakh; and DQA1*03:01/02/03-DQB1*03:03 (11.25%) in Hui. The phylogenetic dendrograms constructed based on the allele frequencies of HLA-DRB1, -DQA1 and -DQB1 in 13 populations (e.g. Asian, Central Asian and European) revealed that the Han and Hui populations were clustered together and closest to Han population from China, while the Kazakh and Uyghur populations were closest to each other and two ethnic groups were clustered together with Central Asian and European populations.

Keywords

Ethnic groups HLA (human leucocyte antigen) class II Xinjiang region

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Grants

  1. 31601404/National Natural Science Foundation of China
  2. 2013DFG31380/Ministry of Science and Technology of the People's Republic of China

MeSH Term

Alleles
Asian People
China
Ethnicity
Female
Gene Frequency
Genetics, Population
Genotype
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DRB1 Chains
Haplotypes
Histocompatibility Antigens Class I
Humans
Male
Phylogeny
Polymorphism, Genetic

Chemicals

HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DQA1 antigen
HLA-DQB1 antigen
HLA-DRB1 Chains
Histocompatibility Antigens Class I
Journal Article

Word Cloud

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