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Rheumatology (Oxford, England)
11 03, 2021;60 (11): 5117-5126.

Association of particulate matter with autoimmune rheumatic diseases among adults in South Korea.

Jun Seok Park, Seulggie Choi, Kyuwoong Kim, Jooyoung Chang, Sung Min Kim, Seong Rae Kim, Gyeongsil Lee, Joung Sik Son, Kyae Hyung Kim, Eun Young Lee, Sang Min Park
Author Information
  1. Jun Seok Park: College of Medicine, Seoul National University Hospital. ORCID
  2. Seulggie Choi: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul.
  3. Kyuwoong Kim: Division of Cancer Control and Policy, National Cancer Control Institute, National Cancer Center, Goyang. ORCID
  4. Jooyoung Chang: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul.
  5. Sung Min Kim: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul.
  6. Seong Rae Kim: College of Medicine, Seoul National University Hospital. ORCID
  7. Gyeongsil Lee: Department of Family Medicine, Seoul National University Hospital.
  8. Joung Sik Son: Department of Family Medicine, Seoul National University Hospital. ORCID
  9. Kyae Hyung Kim: Department of Family Medicine, Seoul National University Hospital.
  10. Eun Young Lee: Division of Rheumatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea.
  11. Sang Min Park: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul. ORCID
PMID: 33560298 DOI: 10.1093/rheumatology/keab127

Abstract

OBJECTIVE: The primary objective of this study was to investigate adverse effects of ambient particulate matter of various sizes on the incidence of the prevalent autoimmune rheumatic diseases (AIRDs): RA, AS and SLE.
METHODS: We investigated 230 034 participants in three metropolitan cities of South Korea from the National Health Insurance Service-National Sample Cohort (NHIS-NSC). Starting from January 2010, subjects were followed up until the first event of prevalent AIRDs, death, or December 2013. The 2008-2009 respective averages of particulate matter2.5 (<2.5 μm) and particulate mattercoarse (2.5 μm to 10 μm) were linked with participants' administrative district codes. Adjusted hazard ratios (aHRs) and 95% CIs were estimated using Cox regression analysis in one- and two-pollutant models.
RESULTS: Adjusted for age, sex, region, and household income, in the two-pollutant model, RA incidence was positively associated with the 10 μg/m³ increment of particulate matter2.5 (aHR = 1.74, 95% CI: 1.06, 2.86), but not with particulate mattercoarse (aHR = 1.27, 95% CI: 0.87, 1.85). In the one-pollutant model, the elevated incidence rate of RA was slightly attenuated (particulate matter2.5 aHR = 1.61, 95% CI: 0.99, 2.61; particulate mattercoarse aHR = 1.13, 95% CI: 0.80, 1.61), with marginal statistical significance for particulate matter2.5. The RA incidence was also higher in the 4th quartile group of particulate matter2.5 compared with the first quartile group (aHR = 1.83, 95% CI: 1.07, 3.11). Adverse effects from particulate matter were not found for AS or SLE in either the one- or two-pollutant models.
CONCLUSION: The important components of particulate matter10 associated with RA incidence were the fine fractions (particulate matter2.5); no positive association was found between particulate matter and AS or SLE.

Keywords

ankylosing spondylitis epidemiology particulate matter rheumatoid arthritis systemic lupus erythematosus

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MeSH Term

Adult
Aged
Autoimmune Diseases
Female
Humans
Incidence
Male
Middle Aged
Particulate Matter
Republic of Korea
Retrospective Studies
Rheumatic Diseases
Young Adult

Chemicals

Particulate Matter
Journal Article

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