An Immuno-Cardiac Model for Macrophage-Mediated Inflammation in COVID-19 Hearts.

Liuliu Yang, Yuling Han, Fabrice Jaffr��, Benjamin E Nilsson-Payant, Yaron Bram, Pengfei Wang, Jiajun Zhu, Tuo Zhang, David Redmond, Sean Houghton, Skyler Uhl, Alain Borczuk, Yaoxing Huang, Chanel Richardson, Vasuretha Chandar, Joshua A Acklin, Jean K Lim, Zhengming Chen, Jenny Xiang, David D Ho, Benjamin R tenOever, Robert E Schwartz, Todd Evans, Shuibing Chen
Author Information
  1. Liuliu Yang: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
  2. Yuling Han: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
  3. Fabrice Jaffr��: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
  4. Benjamin E Nilsson-Payant: Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
  5. Yaron Bram: Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
  6. Pengfei Wang: Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
  7. Jiajun Zhu: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
  8. Tuo Zhang: Genomics Resources Core Facility (T.Z., J.X.), Weill Cornell Medicine, New York, NY.
  9. David Redmond: Division of Regenerative Medicine, Ansary Stem Cell Institute (D.R., S.H.), Weill Cornell Medicine, New York, NY.
  10. Sean Houghton: Division of Regenerative Medicine, Ansary Stem Cell Institute (D.R., S.H.), Weill Cornell Medicine, New York, NY.
  11. Skyler Uhl: Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
  12. Alain Borczuk: Department of Pathology and Laboratory Medicine (A.B.), Weill Cornell Medicine, New York, NY.
  13. Yaoxing Huang: Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
  14. Chanel Richardson: Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
  15. Vasuretha Chandar: Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
  16. Joshua A Acklin: Graduate School of Biomedical Sciences (J.A.A.), Icahn School of Medicine at Mount Sinai, New York, NY.
  17. Jean K Lim: Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
  18. Zhengming Chen: Department of Population Health Sciences (Z.C.), Weill Cornell Medicine, New York, NY.
  19. Jenny Xiang: Genomics Resources Core Facility (T.Z., J.X.), Weill Cornell Medicine, New York, NY.
  20. David D Ho: Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY (P.W., Y. Huang, D.D.H.).
  21. Benjamin R tenOever: Department of Microbiology (B.E.N.-P., S.U., J.K.L., B.R.t.), Icahn School of Medicine at Mount Sinai, New York, NY.
  22. Robert E Schwartz: Division of Gastroenterology and Hepatology, Department of Medicine (Y.B., C.R., V.C., R.E.S.), Weill Cornell Medicine, New York, NY.
  23. Todd Evans: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.
  24. Shuibing Chen: Department of Surgery (L.Y., Y. Han, F.J., J.Z., T.E., S.C.), Weill Cornell Medicine, New York, NY.

Abstract

[Figure: see text].

Keywords

References

  1. J Clin Invest. 2020 May 1;130(5):2620-2629 [PMID: 32217835]
  2. Lancet Respir Med. 2020 Apr;8(4):420-422 [PMID: 32085846]
  3. J Inflamm (Lond). 2019 Jan 29;16:2 [PMID: 30728752]
  4. Lancet. 2020 Mar 28;395(10229):1054-1062 [PMID: 32171076]
  5. Eur J Heart Fail. 2014 Apr;16(4):358-66 [PMID: 24464789]
  6. Nat Rev Immunol. 2011 Oct 14;11(11):723-37 [PMID: 21997792]
  7. JAMA Cardiol. 2020 Jul 1;5(7):802-810 [PMID: 32211816]
  8. Cell Rep Med. 2020 Jul 21;1(4):100052 [PMID: 32835305]
  9. Eur J Heart Fail. 2020 May;22(5):911-915 [PMID: 32275347]
  10. Nature. 2021 Jan;589(7841):270-275 [PMID: 33116299]
  11. Stem Cell Reports. 2019 Jun 11;12(6):1282-1297 [PMID: 31189095]
  12. Cell. 2020 Apr 16;181(2):271-280.e8 [PMID: 32142651]
  13. J Am Coll Cardiol. 2018 Oct 30;72(18):2213-2230 [PMID: 30360829]
  14. Circ Res. 2018 Jan 5;122(1):113-127 [PMID: 29301844]
  15. JAMA. 2020 Mar 17;323(11):1061-1069 [PMID: 32031570]
  16. JAMA Cardiol. 2020 Jul 1;5(7):811-818 [PMID: 32219356]
  17. Nat Med. 2020 Jun;26(6):842-844 [PMID: 32398875]
  18. Circulation. 2018 Nov 27;138(22):2452-2455 [PMID: 30571351]
  19. Lancet. 2020 May 23;395(10237):1607-1608 [PMID: 32386565]
  20. Cardiovasc Res. 2020 Dec 1;116(14):2207-2215 [PMID: 32966582]
  21. Sci Immunol. 2020 May 8;5(47): [PMID: 32385052]
  22. Diabetes Care. 2015 Jul;38(7):1189-96 [PMID: 26049552]
  23. Intensive Care Med. 2020 May;46(5):846-848 [PMID: 32125452]
  24. Lancet Infect Dis. 2020 Oct;20(10):1135-1140 [PMID: 32526193]
  25. Am J Health Syst Pharm. 2012 Dec 15;69(24):2120 [PMID: 23230026]
  26. Nat Rev Immunol. 2014 Jun;14(6):392-404 [PMID: 24854589]
  27. Circ Res. 2019 Jan 18;124(2):263-278 [PMID: 30582448]
  28. J Am Heart Assoc. 2016 Mar 15;5(3):e003196 [PMID: 26979079]
  29. ESC Heart Fail. 2020 Oct;7(5):2440-2447 [PMID: 32529795]
  30. Cytokine. 2015 Jul;74(1):62-8 [PMID: 25649043]
  31. Sci Rep. 2017 Jul 28;7(1):6779 [PMID: 28754958]
  32. Cardiovasc Res. 2020 Mar 1;116(3):658-670 [PMID: 31173076]
  33. Science. 2003 Oct 31;302(5646):875-8 [PMID: 14593182]
  34. Nat Rev Immunol. 2020 Jun;20(6):355-362 [PMID: 32376901]
  35. JAMA Cardiol. 2020 Nov 1;5(11):1281-1285 [PMID: 32730555]
  36. Nat Commun. 2021 May 4;12(1):2506 [PMID: 33947851]
  37. Int J Mol Sci. 2020 Apr 29;21(9): [PMID: 32365634]
  38. Nat Commun. 2020 Oct 8;11(1):5086 [PMID: 33033248]
  39. Nat Med. 2018 Aug;24(8):1234-1245 [PMID: 29892064]
  40. Lancet. 2020 Feb 15;395(10223):497-506 [PMID: 31986264]
  41. Cell Stem Cell. 2020 Jul 2;27(1):125-136.e7 [PMID: 32579880]
  42. Eur Heart J. 2020 Oct 14;41(39):3827-3835 [PMID: 32968776]
  43. Cell. 2020 May 28;181(5):1036-1045.e9 [PMID: 32416070]
  44. JAMA Intern Med. 2020 Jul 1;180(7):934-943 [PMID: 32167524]
  45. J Exp Med. 2020 Jun 1;217(6): [PMID: 32302401]
  46. Stem Cells. 2009 Sep;27(9):2163-74 [PMID: 19658189]

Grants

  1. DP3 DK111907/NIDDK NIH HHS
  2. R35 HL135778/NHLBI NIH HHS
  3. R01 DK119667/NIDDK NIH HHS
  4. R01 CA234614/NCI NIH HHS
  5. R03 DK117252/NIDDK NIH HHS
  6. R01 DK116075/NIDDK NIH HHS
  7. R01 DK121072/NIDDK NIH HHS
  8. R01 AI107301/NIAID NIH HHS
  9. R01 DK124463/NIDDK NIH HHS
  10. F31 HL149295/NHLBI NIH HHS
  11. U01 DK127777/NIDDK NIH HHS
  12. R21 AI149033/NIAID NIH HHS

MeSH Term

Adult
Aged
Aged, 80 and over
COVID-19
Coculture Techniques
Female
Humans
Immunity, Cellular
Inflammation Mediators
Macrophages
Male
Middle Aged
Myocardium
Myocytes, Cardiac
Pluripotent Stem Cells
Sequence Analysis, RNA

Chemicals

Inflammation Mediators