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Current breast cancer reports
Mar, 2021;13 (1): 1-18.

Model-Based Patterns of Lymphedema Symptomatology: Phenotypic and Biomarker Characterization.

Mei R Fu, Bradley E Aouizerat, Gary Yu, Yvette Conley, Deborah Axelrod, Amber A Guth, Jean-Pierre Gagner, Jeanna M Qiu, David Zagzag
Author Information
  1. Mei R Fu: William F. Connell School of Nursing, Boston College, Chestnut Hill, MA 02467, USA. ORCID
  2. Bradley E Aouizerat: Bluestone Center for Clinical Research, Department of Oral and Maxillofacial Surgery, College of Dentistry, New York University, New York, NY, USA.
  3. Gary Yu: Rory Meyers College of Nursing, New York University, New York, NY, USA.
  4. Yvette Conley: School of Nursing, University of Pittsburgh, Pittsburgh, PA, USA.
  5. Deborah Axelrod: Department of Surgery, New York University School of Medicine, New York, NY, USA.
  6. Amber A Guth: Department of Surgery, New York University School of Medicine, New York, NY, USA.
  7. Jean-Pierre Gagner: Department of Pathology, Microvascular and Molecular Neuro-Oncology Laboratory, NYU Langone Health, New York, NY, USA.
  8. Jeanna M Qiu: Harvard Medical School, Boston, MA, USA.
  9. David Zagzag: Division of Neuropathology and Department of Neurosurgery, NYU Langone Health, New York, NY, USA.
PMID: 34322193 DOI: 10.1007/s12609-020-00397-6

Abstract

PURPOSE OF THE STUDY: More than 50% of breast cancer survivors without a diagnosis of lymphedema suffer daily from numerous and co-occurring lymphedema symptoms. This study aimed to identify lymphedema symptom patterns and the association of such patterns with phenotypic characteristics and biomarkers using latent class analysis (LCA). A prospective, descriptive, and repeated-measure design was used to enroll 140 women and collect data.
RECENT FINDINGS: LCA identified three distinct lymphedema symptom classes at 8 weeks and 12 months post-surgery: low, moderate, and severe symptom classes and associated phenotypic characteristics. Participants were more likely to be in the severe symptom classes at 12 months post-surgery if they had lower education level, cording, an axillary syndrome at 8 weeks post-surgery, neoadjuvant chemotherapy, and radiation.
SUMMARY: Pre-surgery level of IL1-a, IL-6, IL-8, and VEGF was associated with the severe symptom class at 8 weeks post-surgery, suggesting that such biomarkers may be used to predict risk for lymphedema symptoms.

Keywords

Bioimpedance Biomarkers Latent class analysis Limbvolume Lymphedema Phenotype Symptom Symptom distress

References

Mhealth. 2016 Jul;2: [PMID: 27493951]
Lymphat Res Biol. 2012 Mar;10(1):2-13 [PMID: 22404826]
Lymphat Res Biol. 2014 Mar;12(1):10-22 [PMID: 24502445]
Ann Surg Oncol. 2014 Oct;21(11):3481-9 [PMID: 24809302]
Clin J Oncol Nurs. 2014;18 Suppl:68-79 [PMID: 25427610]
Nurs Res. 2008 Nov-Dec;57(6):416-25 [PMID: 19018216]
Nurs Res. 2017 Mar/Apr;66(2):85-94 [PMID: 28252570]
Arch Sex Behav. 2015 Feb;44(2):421-8 [PMID: 25104104]
Nurs Res. 2003 Nov-Dec;52(6):370-9 [PMID: 14639083]
PLoS One. 2013 Dec 12;8(12):e76091 [PMID: 24348989]
Lymphology. 2013 Jun;46(2):85-96 [PMID: 24354107]
Lymphat Res Biol. 2005;3(4):208-17 [PMID: 16379589]
Rehabil Nurs. 2015 Sep-Oct;40(5):310-9 [PMID: 25042377]
Cancer. 2001 Sep 15;92(6):1368-77 [PMID: 11745212]
Breast Cancer (Dove Med Press). 2015 Oct 15;7:345-52 [PMID: 26527899]
Med Arh. 2007;61(4):203-6 [PMID: 18297990]
Breast. 2016 Oct;29:231-40 [PMID: 27460425]
Eur J Oncol Nurs. 2016 Feb;20:10-6 [PMID: 26071198]
PLoS One. 2013 Apr 16;8(4):e60164 [PMID: 23613720]
Blood Purif. 2001;19(3):314-21 [PMID: 11244192]
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):775-82 [PMID: 17416770]
Ann Oncol. 2009 Oct;20(10):1639-46 [PMID: 19549711]
Ann Epidemiol. 2015 Jul;25(7):469-74 [PMID: 25873383]
J Pain Symptom Manage. 2009 Dec;38(6):849-59 [PMID: 19819668]
Stat Med. 1986 Jan-Feb;5(1):21-7 [PMID: 3961312]

Grants

  1. P60 MD000538/NIMHD NIH HHS
  2. R01 CA214085/NCI NIH HHS
  3. R21 NR012288/NINR NIH HHS
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