Machine learning algorithms utilizing blood parameters enable early detection of immunethrombotic dysregulation in COVID-19.

Zhaoming Zhou, Xiang Zhou, Liming Cheng, Lei Wen, Taixue An, Heng Gao, Hongrong Deng, Qi Yan, Xinlu Zhang, Youjiang Li, Yixing Liao, Xin-Zu Chen, Bin Nie, Jie Cheng, Guanhua Deng, Shengqiang Wang, Juan Li, Hanqi Yin, Mengxian Zhang, Linbo Cai, Lei Zheng, Minglun Li, Bleddyn Jones, Longhua Chen, Amir Abdollahi, Meijuan Zhou, Ping-Kun Zhou, Cheng Zhou
Author Information
  1. Zhaoming Zhou: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ORCID
  2. Xiang Zhou: Department of Anesthesiology, General Hospital of Central Theater Command of PLA, Wuhan, China.
  3. Liming Cheng: Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  4. Lei Wen: Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
  5. Taixue An: Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  6. Heng Gao: Department of Neurosurgery, Jiangyin Affiliated Hospital of Southeast University School of Medicine, Jiangyin, China.
  7. Hongrong Deng: Department of Endocrinology and Metabolism, Guangdong Provincial Key Laboratory of Diabetology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
  8. Qi Yan: Department of Geriatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  9. Xinlu Zhang: Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  10. Youjiang Li: Department of Clinical Laboratory, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu, China.
  11. Yixing Liao: Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
  12. Xin-Zu Chen: Department of Gastrointestinal and Hernia Surgery, The Second People's Hospital of Yibin - West China Yibin Hospital, Sichuan University, Yibin, China.
  13. Bin Nie: Department of Laboratory Medicine, The Second People's Hospital of Yibin - West China Yibin Hospital, Sichuan University, Yibin, China.
  14. Jie Cheng: Center for Reproductive Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
  15. Guanhua Deng: Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
  16. Shengqiang Wang: Department of Rehabilitation Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  17. Juan Li: Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
  18. Hanqi Yin: South China Institute of Biomedicine, Guangzhou, China.
  19. Mengxian Zhang: Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  20. Linbo Cai: Department of Oncology, Guangdong Sanjiu Brain Hospital, Guangzhou, China.
  21. Lei Zheng: Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  22. Minglun Li: Department of Radiation Oncology, University Hospital, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany.
  23. Bleddyn Jones: Gray Laboratory, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, Oxford, UK.
  24. Longhua Chen: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
  25. Amir Abdollahi: Translational Radiation Oncology, German Cancer Research Center (DKFZ) and University Heidelberg School of Medicine, Heidelberg, Germany.
  26. Meijuan Zhou: Department of Radiation Medicine, School of Public Health, Southern Medical University, Guangzhou, China.
  27. Ping-Kun Zhou: Department of Radiation Biology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China.
  28. Cheng Zhou: Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, China. ORCID

Abstract

No abstract text available.

References

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Grants

  1. A2020499/Guangdong Medical Research Foundation
  2. A2020505/Guangdong Medical Research Foundation
  3. B2021139/Guangdong Medical Research Foundation
  4. B2021203/Guangdong Medical Research Foundation
  5. 2019M662974/China Postdoctoral Science Foundation
  6. 2020T130052ZX/China Postdoctoral Science Foundation
  7. 81703166/National Natural Science Foundation of China
  8. 2019A1515011943/Natural Science Foundation of Guangdong Province
  9. 202002030445/Science and Technology Program of Guangzhou
  10. 202002030086/Science and Technology Program of Guangzhou

MeSH Term

Algorithms
COVID-19
Early Diagnosis
Gene Expression Profiling
Humans
Machine Learning
SARS-CoV-2
Thrombosis

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