Regeneration Roadmap: database resources for regenerative biology.
Wang Kang, Tong Jin, Tao Zhang, Shuai Ma, Haoteng Yan, Zunpeng Liu, Zhejun Ji, Yusheng Cai, Si Wang, Moshi Song, Jie Ren, Baoyang Hu, Qi Zhou, Weiqi Zhang, Jing Qu, Yiming Bao, Guang-Hui Liu
Author Information
- Wang Kang: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
- Tong Jin: China National Center for Bioinformation, Beijing 100101, China.
- Tao Zhang: China National Center for Bioinformation, Beijing 100101, China.
- Shuai Ma: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
- Haoteng Yan: Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
- Zunpeng Liu: Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
- Zhejun Ji: Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
- Yusheng Cai: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
- Si Wang: Advanced Innovation Center for Human Brain Protection, and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.
- Moshi Song: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
- Jie Ren: China National Center for Bioinformation, Beijing 100101, China.
- Baoyang Hu: Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
- Qi Zhou: Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
- Weiqi Zhang: China National Center for Bioinformation, Beijing 100101, China.
- Jing Qu: Institute for Stem cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.
- Yiming Bao: China National Center for Bioinformation, Beijing 100101, China.
- Guang-Hui Liu: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. ORCID
Regeneration plays an instrumental role in biological development and damage repair by constructing and replacing cells, tissues, and organs. Since regenerative capacity declines with age, promoting regeneration is heralded as a potential strategy for delaying aging. On this premise, mechanisms that regulate regeneration have been extensively studied across species and in different tissues. However, an open and comprehensive database collecting and standardizing the abundant data generated in regeneration research, such as high-throughput sequencing data, remains to be developed. In this work, we constructed Regeneration Roadmap to systematically and comprehensively collect such information over 2.38 million data entries across 11 species and 36 tissues, including regeneration-related genes, bulk and single-cell transcriptomics, epigenomics, and pharmacogenomics data. In this database, users can explore regulatory and expression changes of regeneration-associated genes in different species and tissues. Regeneration Roadmap provides the research community with a long-awaited and valuable data resource featuring convenient computing and visualizing tools, which is publicly available at https://ngdc.cncb.ac.cn/regeneration/index.
Aging
Animals
Databases, Factual
Databases, Genetic
Epigenomics
Humans
Regeneration
Transcriptome
