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12 23, 2021;13 (1):

Circular RNA circYPEL2: A Novel Biomarker in Cervical Cancer.

Xinyang Zhang, Siqi Yang, Wenbo Chen, Xin Dong, Rongyu Zhang, Haidong Ye, Xiangfei Mei, Huan Liu, Yu Fang, Chunjiang He
Author Information
  1. Xinyang Zhang: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  2. Siqi Yang: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  3. Wenbo Chen: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China. ORCID
  4. Xin Dong: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  5. Rongyu Zhang: College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
  6. Haidong Ye: College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
  7. Xiangfei Mei: School of Basic Medical Sciences, Wuhan University, Wuhan 430071, China.
  8. Huan Liu: University of Science and Technology of China, Hefei 230026, China.
  9. Yu Fang: College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China.
  10. Chunjiang He: College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China. ORCID
PMID: 35052380 DOI: 10.3390/genes13010038

Abstract

Cervical cancer (CC) is one of the most threatening diseases in women. Circular RNAs (circRNAs) have been reported to be cancer hallmarks, but typical circRNAs in CC were rarely indicated. Through high-throughput sequencing in CC and normal cervix tissues, circYPEL2 (hsa_circ_0005600) was proposed as a candidate circRNA. CircYPEL2 exhibited significantly high expression in CC tissue and strong stability in CC cell lines. Furthermore, knockdown and overexpression of circYPEL2 indicated the potential involvement in CC proliferation, migration and invasion. Finally, the downstream regulatory genes of circYPEL2 were investigated by knockdown experiment in CC cell lines with high-throughput sequencing. In summary, our work identified circYPEL2 as a potential biomarker for clinical research of cervical cancer.

Keywords

biomarker cervical cancer circRNA

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MeSH Term

Apoptosis
Biomarkers, Tumor
Cell Line, Tumor
Cell Movement
Cell Proliferation
Female
Gene Expression Regulation, Neoplastic
Humans
RNA, Circular
Uterine Cervical Neoplasms

Chemicals

Biomarkers, Tumor
RNA, Circular
Journal Article Research Support, Non-U.S. Gov't

Links to CNCB-NGDC Resources

GEN: GEND000508 (Circular RNA YPEL2 promotes cell proliferation, migration and invasion as a biomaker in cervical cancer)

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