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Cold Spring Harbor perspectives in medicine
12 01, 2022;12 (12):

Human Endothelial Colony-Forming Cells.

Juan M Melero-Martin
Author Information
  1. Juan M Melero-Martin: Department of Cardiac Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. ORCID
PMID: 35379656 DOI: 10.1101/cshperspect.a041154

Abstract

Endothelial colony-forming cells (ECFCs) are progenitor cells that can give rise to colonies of highly proliferative vascular endothelial cells (ECs) with clonal expansion and in vivo blood vessel-forming potential. More than two decades ago, the identification of ECFCs in human peripheral blood created tremendous opportunities as having a clinically accessible source of autologous ECs could facilitate meaningful therapies with the potential to impact multiple vascular diseases. Nevertheless, until recently, the field of endothelial progenitor cells has been plagued with ambiguities and controversies, and reaching a consensus on the definition of ECFCs has not been straightforward. Moreover, although the basic phenotypical and functional characteristics of cultured ECFCs are now well established, some fundamental questions such as the origin of ECFCs and their physiological roles in health and disease remain incompletely understood. Here, I highlight some critical studies that have shaped our current understanding of ECFCs in humans. Insights into the biological attributes of ECFCs are essential for facilitating the clinical translation of their therapeutic potential.

References

Br J Cancer. 2007 Aug 20;97(4):513-22 [PMID: 17653078]
Circ Res. 2008 Jul 18;103(2):128-30 [PMID: 18635829]
Methods Mol Biol. 2021;2206:193-203 [PMID: 32754819]
BMJ. 2014 Apr 28;348:g2688 [PMID: 24778175]
Blood. 2011 Jan 20;117(3):1071-80 [PMID: 21048155]
Annu Rev Cell Dev Biol. 1995;11:73-91 [PMID: 8689573]
Adv Healthc Mater. 2021 Jul;10(13):e2100070 [PMID: 33882194]
Nat Med. 1999 Apr;5(4):434-8 [PMID: 10202935]
Tissue Eng Part A. 2009 Nov;15(11):3473-86 [PMID: 19435420]
Blood. 2009 Jul 16;114(3):723-32 [PMID: 19369228]
Acta Biomater. 2011 Dec;7(12):4222-8 [PMID: 21798379]
Stem Cells. 2010 Jul;28(7):1165-77 [PMID: 20506500]
Circulation. 2014 May 27;129(21):2125-35 [PMID: 24657995]
J Biol Chem. 1999 Sep 10;274(37):26141-8 [PMID: 10473565]
J Clin Invest. 1999 May;103(9):1231-6 [PMID: 10225965]
Cell Rep. 2019 May 28;27(9):2748-2758.e3 [PMID: 31141696]
Hum Mutat. 2006 Mar;27(3):295 [PMID: 16470589]
Circ Res. 2009 Jun 19;104(12):1410-20 [PMID: 19443841]
EMBO J. 2012 Feb 15;31(4):842-55 [PMID: 22179698]
Science. 1997 Feb 14;275(5302):964-7 [PMID: 9020076]
Exp Hematol. 2007 Jul;35(7):1109-18 [PMID: 17588480]
Biomaterials. 2009 Aug;30(22):3742-8 [PMID: 19394079]
FASEB J. 2006 Aug;20(10):1739-41 [PMID: 16807367]
Lancet. 1989 Sep 9;2(8663):577-80 [PMID: 2570282]
BMC Med Genomics. 2010 May 13;3:18 [PMID: 20465783]
Diabetes. 2008 Mar;57(3):724-31 [PMID: 18086900]
Cardiovasc Res. 2005 Nov 1;68(2):235-48 [PMID: 15993872]
Blood. 2007 Jun 1;109(11):4761-8 [PMID: 17327403]
Tissue Eng Part B Rev. 2016 Oct;22(5):371-382 [PMID: 27032435]
Circulation. 2019 Oct 29;140(18):1524-1526 [PMID: 31657952]
Nat Med. 2015 Jul;21(7):777-85 [PMID: 26076038]
Angiogenesis. 2013 Jan;16(1):147-57 [PMID: 22983452]
Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):e13-21 [PMID: 22199368]
Am J Physiol Lung Cell Mol Physiol. 2013 Jul 1;305(1):L73-81 [PMID: 23666751]
PLoS One. 2014 May 15;9(5):e96155 [PMID: 24830850]
Cytotherapy. 2014 Feb;16(2):213-24 [PMID: 24280239]
Blood. 2000 Feb 1;95(3):952-8 [PMID: 10648408]
Front Med (Lausanne). 2018 Oct 23;5:295 [PMID: 30406106]
Cardiovasc Res. 2001 Feb 16;49(3):671-80 [PMID: 11166280]
Nat Biomed Eng. 2017;1: [PMID: 28868207]
Kidney Int. 2016 Dec;90(6):1238-1250 [PMID: 27650731]
Sci Rep. 2016 Aug 23;6:31589 [PMID: 27549930]
Blood. 2007 Jul 1;110(1):151-60 [PMID: 17379743]
Circ Res. 2012 Feb 17;110(4):624-37 [PMID: 22343557]
Diabetes. 2015 Jul;64(7):2664-75 [PMID: 25720387]
Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2696-708 [PMID: 18515596]
Tissue Eng. 2007 Oct;13(10):2577-88 [PMID: 17655487]
Circ Res. 2003 Nov 28;93(11):1023-5 [PMID: 14605020]
Blood. 2011 Dec 15;118(25):6718-21 [PMID: 22039257]
Blood. 2005 Jan 1;105(1):199-206 [PMID: 15345590]
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5906-13 [PMID: 20554606]
Stem Cell Res. 2017 May;21:148-159 [PMID: 28499264]
Stem Cells. 2013 Dec;31(12):2813-26 [PMID: 23897750]
J Clin Invest. 2000 Jan;105(1):71-7 [PMID: 10619863]
Nat Med. 2003 Jun;9(6):702-12 [PMID: 12778169]
Biomaterials. 2009 Feb;30(4):526-34 [PMID: 18977026]
Blood. 2008 Feb 1;111(3):1302-5 [PMID: 17993613]
Circ Res. 2008 Jul 18;103(2):194-202 [PMID: 18556575]
J Tissue Eng Regen Med. 2018 Feb;12(2):546-556 [PMID: 28875579]
Burns. 2013 Jun;39(4):694-704 [PMID: 23102579]
J Am Coll Cardiol. 2006 Oct 17;48(8):1579-87 [PMID: 17045891]
Arterioscler Thromb Vasc Biol. 2008 Sep;28(9):1584-95 [PMID: 18669889]
Blood Coagul Fibrinolysis. 2017 Oct;28(7):521-533 [PMID: 28362648]
Eur Cell Mater. 2018 May 30;35:335-348 [PMID: 29873804]
Eur Respir J. 2012 Dec;40(6):1516-22 [PMID: 22496315]
Circulation. 2014 May 27;129(21):2144-57 [PMID: 24710033]
Stem Cell Rev Rep. 2018 Apr;14(2):223-235 [PMID: 29101610]
Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):1897-904 [PMID: 20689075]
Am J Respir Crit Care Med. 2009 Sep 15;180(6):540-6 [PMID: 19574444]
Blood. 2004 Nov 1;104(9):2752-60 [PMID: 15226175]
PLoS One. 2013 Jun 10;8(6):e65114 [PMID: 23762293]
J Pediatr. 2014 Mar;164(3):566-571 [PMID: 24315508]
Hypertension. 2014 Jul;64(1):165-71 [PMID: 24752434]
Angiogenesis. 2012 Sep;15(3):443-55 [PMID: 22527199]
Stem Cells. 2007 Oct;25(10):2660-9 [PMID: 17615271]
Adv Funct Mater. 2012 May 23;22(10):2027-2039 [PMID: 22907987]
Am J Obstet Gynecol. 2011 Mar;204(3):254.e8-254.e15 [PMID: 21167470]
J Clin Invest. 2017 May 1;127(5):1613-1615 [PMID: 28459428]
Cell Stem Cell. 2014 May 1;14(5):553-4 [PMID: 24792110]
Blood. 2000 May 15;95(10):3106-12 [PMID: 10807776]
Thromb Res. 2021 Oct;206:55-59 [PMID: 34411875]
J Clin Endocrinol Metab. 2013 Dec;98(12):4953-60 [PMID: 24106289]
Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1094-103 [PMID: 20453169]
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10137-42 [PMID: 24982174]
Blood. 2013 Apr 4;121(14):2773-84 [PMID: 23355534]
Br J Haematol. 2008 Jul;142(1):115-8 [PMID: 18477035]
Thromb Res. 2016 Jan;137:157-168 [PMID: 26597044]
J Am Heart Assoc. 2021 May 18;10(10):e020606 [PMID: 33955230]
Development. 1988 Mar;102(3):471-8 [PMID: 2460305]
Hum Mol Genet. 2013 Sep 15;22(18):3667-79 [PMID: 23669347]
Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3422-7 [PMID: 10725398]
Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2137-43 [PMID: 18818419]
Microvasc Res. 2015 Sep;101:72-81 [PMID: 26122935]
J Thromb Haemost. 2019 Sep;17(9):1544-1554 [PMID: 31265169]
Am J Pathol. 2015 Aug;185(8):2309-23 [PMID: 26073035]
JCI Insight. 2016;1(1): [PMID: 26900601]
Cell Mol Life Sci. 2019 Feb;76(3):421-439 [PMID: 30315324]
Blood. 2011 Nov 17;118(20):5420-8 [PMID: 21937702]
Adv Exp Med Biol. 2003;522:59-74 [PMID: 12674211]
Arterioscler Thromb Vasc Biol. 2012 Apr;32(4):1045-53 [PMID: 22282356]
Stem Cells. 2013 Feb;31(2):338-48 [PMID: 23165527]
Blood. 2009 Jun 25;113(26):6716-25 [PMID: 19321860]
Circulation. 2017 Dec 19;136(25):2451-2467 [PMID: 28971999]
J Thromb Haemost. 2019 Jul;17(7):1190-1194 [PMID: 31119878]
PLoS One. 2017 Sep 14;12(9):e0183827 [PMID: 28910333]
Stem Cells Transl Med. 2018 Jan;7(1):59-67 [PMID: 29164803]
Stem Cell Rev Rep. 2011 Mar;7(1):208-20 [PMID: 20526754]
Brain Res. 2016 Jul 1;1642:209-218 [PMID: 27038754]
Blood. 2004 Mar 1;103(5):1669-75 [PMID: 14576065]
Blood. 2007 Mar 1;109(5):1801-9 [PMID: 17053059]
J Cell Mol Med. 2017 Dec;21(12):3405-3419 [PMID: 28631889]
Dermatol Surg. 2008 Feb;34(2):137-46 [PMID: 18190540]
Cell Transplant. 2007;16(9):887-97 [PMID: 18293887]
N Engl J Med. 1971 Oct 14;285(16):884-7 [PMID: 4939537]
Stem Cells Transl Med. 2017 May;6(5):1316-1320 [PMID: 28296182]
Blood. 2013 Apr 4;121(14):2762-72 [PMID: 23426949]
Am J Physiol Heart Circ Physiol. 2004 Aug;287(2):H480-7 [PMID: 15277191]
Blood. 2009 Oct 1;114(14):3127-30 [PMID: 19628707]
Sci Rep. 2017 Apr 10;7(1):770 [PMID: 28396600]
PLoS One. 2015 Jun 15;10(6):e0129935 [PMID: 26076450]
Clin Med Res. 2006 Mar;4(1):66-78 [PMID: 16595794]
Eur J Prev Cardiol. 2015 Dec;22(12):1557-66 [PMID: 26276790]
Cell Stem Cell. 2018 Mar 1;22(3):384-397.e6 [PMID: 29429943]
Cardiovasc Res. 2004 Apr 1;62(1):176-84 [PMID: 15023564]
Methods Enzymol. 2008;445:303-29 [PMID: 19022065]
Ann Hematol. 2004 Dec;83(12):733-8 [PMID: 15372203]
Angiogenesis. 2018 Aug;21(3):425-532 [PMID: 29766399]
Blood. 2008 Apr 1;111(7):3872-9 [PMID: 18156497]
Angiogenesis. 2013 Oct;16(4):773-84 [PMID: 23666122]
Sci Adv. 2020 Jul 24;6(30):eaba7606 [PMID: 32832668]
Arterioscler Thromb Vasc Biol. 2004 Feb;24(2):288-93 [PMID: 14699017]
Cancer Gene Ther. 2010 Dec;17(12):855-63 [PMID: 20725100]
Gene Ther. 2007 Nov;14(22):1573-86 [PMID: 17898797]
Circ Res. 2015 Jul 3;117(2):121-8 [PMID: 25940550]
Blood. 2002 Jan 15;99(2):457-62 [PMID: 11781225]
Blood. 2011 Mar 3;117(9):2700-7 [PMID: 21212285]
Angiogenesis. 2021 May;24(2):327-344 [PMID: 33454888]
Cold Spring Harb Perspect Med. 2012 Jul;2(7):a006692 [PMID: 22762017]
Angiogenesis. 2013 Oct;16(4):735-44 [PMID: 23636611]
Circ Res. 2014 Feb 14;114(4):677-88 [PMID: 24334027]
J Surg Res. 2013 Nov;185(1):441-9 [PMID: 23953790]
Blood. 1998 Jul 15;92(2):362-7 [PMID: 9657732]
J Immunol Methods. 1986 Dec 24;95(2):273-6 [PMID: 3794346]
Stem Cells Int. 2012;2012:346735 [PMID: 22550504]
Blood. 2011 Aug 11;118(6):1699-709 [PMID: 21659549]
Biomaterials. 2016 Aug;97:51-61 [PMID: 27162074]
Pediatr Res. 2008 Jul;64(1):68-73 [PMID: 18360305]
Tissue Eng Part C Methods. 2015 Mar;21(3):274-83 [PMID: 25091645]
JCI Insight. 2017 Jan 26;2(2):e89906 [PMID: 28138561]
Blood. 2004 Apr 1;103(7):2577-84 [PMID: 14630797]
Am J Physiol Renal Physiol. 2017 May 1;312(5):F897-F907 [PMID: 28228404]
Exp Eye Res. 2019 May;182:144-155 [PMID: 30876881]
Tissue Eng. 2005 Sep-Oct;11(9-10):1332-45 [PMID: 16259589]
Tissue Eng Part A. 2010 Feb;16(2):585-94 [PMID: 19737050]
Am J Respir Crit Care Med. 2009 Oct 15;180(8):780-7 [PMID: 19628780]
Blood. 2018 Jul 12;132(2):132-140 [PMID: 29866817]
Basic Res Cardiol. 2011 Nov;106(6):1397-410 [PMID: 21904841]
Circulation. 2003 Mar 4;107(8):1164-9 [PMID: 12615796]
J Am Heart Assoc. 2016 Apr 18;5(4):e002288 [PMID: 27091182]
Exp Hematol. 2009 Jan;37(1):8-9 [PMID: 19013004]
Am J Respir Crit Care Med. 2018 Mar 1;197(5):665-668 [PMID: 28753388]
Cytotherapy. 2011 Jul;13(6):712-21 [PMID: 21250867]
J Neurotrauma. 2013 Dec 15;30(24):2080-8 [PMID: 23957220]
Am J Respir Crit Care Med. 2009 Sep 1;180(5):454-61 [PMID: 19483112]
Circulation. 2014 Apr 29;129(17):1770-80 [PMID: 24503951]
Blood. 2005 Apr 1;105(7):2783-6 [PMID: 15585655]
Arterioscler Thromb Vasc Biol. 2010 Aug;30(8):1569-75 [PMID: 20508204]
Arterioscler Thromb Vasc Biol. 2007 Jul;27(7):1572-9 [PMID: 17495235]
Circulation. 2005 Sep 13;112(11):1618-27 [PMID: 16145003]
J Thromb Haemost. 2010 Sep;8(9):2042-52 [PMID: 20546120]
J Thromb Haemost. 2015 Oct;13(10):1854-66 [PMID: 26270243]

Grants

  1. R01 HL128452/NHLBI NIH HHS
  2. R01 HL151450/NHLBI NIH HHS
  3. R01 HL152133/NHLBI NIH HHS

MeSH Term

Humans
Endothelial Progenitor Cells
Stem Cells
Cells, Cultured
Neovascularization, Physiologic
Journal Article Research Support, N.I.H., Extramural

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